FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163392590> ?p ?o ?g. }

• W2163392590 endingPage "509" @default.
• W2163392590 startingPage "502" @default.
• W2163392590 abstract "To determine the prognostic utility of tauopathy-associated single nucleotide polymorphisms (SNPs) in sporadic behavioral-variant frontotemporal dementia (bvFTD).Eighty-one patients with sporadic bvFTD were genotyped for tauopathy-associated SNPs at rs8070723 (microtubule-associated protein tau [MAPT]) and rs1768208 (myelin-associated oligodendrocyte basic protein [MOBP]). We performed a retrospective case-control study comparing age at onset and disease duration between carriers of ≥1 polymorphism allele and noncarriers for these SNPs. Subanalyses were performed for autopsied subgroups with tauopathy (n = 20) and TDP-43 proteinopathy (n = 12). To identify a potential biological basis for disease duration, neuroimaging measures of white matter integrity were evaluated (n = 37).Carriers of risk allele (T) in rs1768208 (i.e., MOBP RA+) had a shorter median disease duration (TC/TT = 5.5 years, CC = 9.5 years; p = 0.02). This was also found in the subset of cases with autopsy-confirmed tauopathies (p = 0.04) but not with TDP-43 proteinopathies (p > 0.1). By comparison, polymorphisms at rs8070723 (MAPT) had no effect on disease duration (p > 0.1), although carriers of protective allele (G) in rs8070723 had a younger median age at onset (AG/GG = 54.5 years, AA = 58 years; p < 0.01). MOBP RA+ patients had increased radial diffusivity in the superior corona radiata and midbrain, and reduced fractional anisotropy in the superior corona radiata as well as superior and inferior longitudinal fasciculi compared with noncarriers (p < 0.01).The rs1768208 risk polymorphism in MOBP may have prognostic value in bvFTD. MOBP RA+ patients have more severe white matter degeneration in bvFTD that may contribute to shorter disease duration. Future studies are needed to help confirm these findings." @default.
• W2163392590 created "2016-06-24" @default.
• W2163392590 creator A5021394368 @default.
• W2163392590 creator A5021597228 @default.
• W2163392590 creator A5036539992 @default.
• W2163392590 creator A5037938359 @default.
• W2163392590 creator A5041309484 @default.
• W2163392590 creator A5043568911 @default.
• W2163392590 creator A5058899383 @default.
• W2163392590 creator A5065852445 @default.
• W2163392590 creator A5068489215 @default.
• W2163392590 creator A5080119092 @default.
• W2163392590 creator A5081337965 @default.
• W2163392590 creator A5088881304 @default.
• W2163392590 date "2014-07-03" @default.
• W2163392590 modified "2023-10-16" @default.
• W2163392590 title "Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia" @default.
• W2163392590 cites W1967674497 @default.
• W2163392590 cites W1990438734 @default.
• W2163392590 cites W1992589625 @default.
• W2163392590 cites W1994089264 @default.
• W2163392590 cites W2009870816 @default.
• W2163392590 cites W2009925591 @default.
• W2163392590 cites W2012453573 @default.
• W2163392590 cites W2019685186 @default.
• W2163392590 cites W2021997569 @default.
• W2163392590 cites W2022371215 @default.
• W2163392590 cites W2023141534 @default.
• W2163392590 cites W2025047388 @default.
• W2163392590 cites W2032352894 @default.
• W2163392590 cites W2039405182 @default.
• W2163392590 cites W2043778544 @default.
• W2163392590 cites W2046485522 @default.
• W2163392590 cites W2049128488 @default.
• W2163392590 cites W2050252352 @default.
• W2163392590 cites W2067439875 @default.
• W2163392590 cites W2077311804 @default.
• W2163392590 cites W2085027326 @default.
• W2163392590 cites W2085110439 @default.
• W2163392590 cites W2097433680 @default.
• W2163392590 cites W2098399185 @default.
• W2163392590 cites W2102286051 @default.
• W2163392590 cites W2105026121 @default.
• W2163392590 cites W2106839031 @default.
• W2163392590 cites W2117756648 @default.
• W2163392590 cites W2120550261 @default.
• W2163392590 cites W2123085033 @default.
• W2163392590 cites W2123177715 @default.
• W2163392590 cites W2128030851 @default.
• W2163392590 cites W2132193210 @default.
• W2163392590 cites W2141349376 @default.
• W2163392590 cites W2143604549 @default.
• W2163392590 cites W2147948236 @default.
• W2163392590 cites W2149168676 @default.
• W2163392590 cites W2156631220 @default.
• W2163392590 cites W2159468210 @default.
• W2163392590 cites W2166543157 @default.
• W2163392590 doi "https://doi.org/10.1212/wnl.0000000000000668" @default.
• W2163392590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4141997" @default.
• W2163392590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24994843" @default.
• W2163392590 hasPublicationYear "2014" @default.
• W2163392590 type Work @default.
• W2163392590 sameAs 2163392590 @default.
• W2163392590 citedByCount "22" @default.
• W2163392590 countsByYear W21633925902014 @default.
• W2163392590 countsByYear W21633925902015 @default.
• W2163392590 countsByYear W21633925902016 @default.
• W2163392590 countsByYear W21633925902018 @default.
• W2163392590 countsByYear W21633925902019 @default.
• W2163392590 countsByYear W21633925902020 @default.
• W2163392590 countsByYear W21633925902021 @default.
• W2163392590 countsByYear W21633925902023 @default.
• W2163392590 crossrefType "journal-article" @default.
• W2163392590 hasAuthorship W2163392590A5021394368 @default.
• W2163392590 hasAuthorship W2163392590A5021597228 @default.
• W2163392590 hasAuthorship W2163392590A5036539992 @default.
• W2163392590 hasAuthorship W2163392590A5037938359 @default.
• W2163392590 hasAuthorship W2163392590A5041309484 @default.
• W2163392590 hasAuthorship W2163392590A5043568911 @default.
• W2163392590 hasAuthorship W2163392590A5058899383 @default.
• W2163392590 hasAuthorship W2163392590A5065852445 @default.
• W2163392590 hasAuthorship W2163392590A5068489215 @default.
• W2163392590 hasAuthorship W2163392590A5080119092 @default.
• W2163392590 hasAuthorship W2163392590A5081337965 @default.
• W2163392590 hasAuthorship W2163392590A5088881304 @default.
• W2163392590 hasBestOaLocation W21633925902 @default.
• W2163392590 hasConcept C104317684 @default.
• W2163392590 hasConcept C126322002 @default.
• W2163392590 hasConcept C135763542 @default.
• W2163392590 hasConcept C142724271 @default.
• W2163392590 hasConcept C143998085 @default.
• W2163392590 hasConcept C153209595 @default.
• W2163392590 hasConcept C2776925932 @default.
• W2163392590 hasConcept C2777739294 @default.
• W2163392590 hasConcept C2777898937 @default.
• W2163392590 hasConcept C2778641062 @default.
• W2163392590 hasConcept C2778670691 @default.
• W2163392590 hasConcept C2779134260 @default.

• next