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• W2163393326 abstract "Summary Coagulation proteases control cellular homeostasis beyond haemostasis. While the role of coagulation proteases in regulating vascular healing and thrombosis is well established, the mechanism underlying the receptor-dependent regulation of cellular function remain incompletely understood. In particular, the opposing effects of the protease-activated receptor 1 (PAR-1), dependent on the activating proteases thrombin or activated protein C generated a conundrum researchers only recently have begun to decipher. The net-effect (cellular perturbation vs. cellular protection) depends on co-receptors involved, the concentration of the activating protease, the temporal context of receptor activation, and a dynamic process of receptor rearrangement upon receptor activation. The latter scenario recruits receptors to a cytoprotective signalling pathways. Recent insights into these mechanisms are summarized in this article." @default.
• W2163393326 created "2016-06-24" @default.
• W2163393326 creator A5025170171 @default.
• W2163393326 creator A5086990440 @default.
• W2163393326 date "2011-01-01" @default.
• W2163393326 modified "2023-09-25" @default.
• W2163393326 title "The evolving plasticity of coagulation protease-dependent cytoprotective signalling" @default.
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• W2163393326 doi "https://doi.org/10.5482/ha-1162" @default.
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