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• W2163462619 endingPage "385" @default.
• W2163462619 startingPage "371" @default.
• W2163462619 abstract "1. We examined the relationship between calcineurin (protein phosphatase 2B (PP2B) and voltage-operated Ca2+ channels (VOCCs) in NG108-15 cells. PP2B expression in NG108-15 cells was altered by transfection with plasmid constructs containing a full length cDNA of human PP2B beta(3) in sense (CN-15) and antisense (CN-21) orientation. 2. Confocal immunocytochemical localization showed that in wild-type cells, PP2B immunoreactivity is uniformly distributed in undifferentiated cells and located at the inner surface of soma membrane and neurites in differentiated cells. 3. To test the Ca2+ dependence of the VOCC, we used high-frequency stimulation (HFS). The L- and N-type VOCCs decreased by 37 and 52%, respectively, whereas the T-type current was only marginally sensitive to this procedure. FK-506 (2 microM), a specific blocker of PP2B, reduced the inhibition of L- and N-type VOCCs induced by HFS by 30 and 33%, respectively. 4. In CN-15-transfected cells overexpressing PP2B, total high-voltage-activated (HVA) VOCCs were suppressed by about 60% at a test potential of +20 mV. Intracellular addition of EGTA or FK-506 into CN-15-transfected cells induced an up to 5-fold increase of HVA VOCCs. 5. These findings indicate that PP2B activity does not influence the expression of HVA Ca2+ channels, but modulates their function by Ca(2+)-dependent dephosphorylation. Thus HVA VOCCs, in a phosphorylated state under control conditions, are downregulated by PP2B upon stimulation, with the major effect on N-type VOCCs." @default.
• W2163462619 created "2016-06-24" @default.
• W2163462619 creator A5031762065 @default.
• W2163462619 creator A5057057740 @default.
• W2163462619 creator A5063501932 @default.
• W2163462619 date "1998-07-01" @default.
• W2163462619 modified "2023-09-25" @default.
• W2163462619 title "Calcineurin involvement in the regulation of high-threshold Ca²⁺channels in NG108-15 (rodent neuroblastoma × glioma hybrid) cells" @default.
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• W2163462619 doi "https://doi.org/10.1111/j.1469-7793.1998.371bk.x" @default.
• W2163462619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2231037" @default.
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• W2163462619 hasPublicationYear "1998" @default.
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