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- W2163478082 endingPage "1049" @default.
- W2163478082 startingPage "1038" @default.
- W2163478082 abstract "Background Human gastroenteropancreatic neuroendocrine tumours are functionally and biologically heterogeneous, but their exact growth factor receptor expression pattern, important for onco- and carcinogenesis, remains unknown. Methods This study searched for the mRNA expression pattern of six tyrosine- and serine/threonine kinase receptors [hepatocyte growth factor (HGFR), fibroblast growth factor (FGFR), epidermal growth factor (EGFR), insulin-like growth factor (IGF)-1R, transforming growth factor (TGF)-βR1, TGF-βR2] together with the five somatostatin receptors in human gastroenteropancreatic neuroendocrine tumours (gastrinomas, insulinomas, tumours with carcinoid syndrome, functionally inactive neuroendocrine tumours) using reverse transcriptase-polymerase chain reaction (RT-PCR). Results EGF receptor was expressed almost exclusively in gastrinomas. Among the four tumour subtypes, expression frequencies of the somatostatin receptors 1 and 5, HGF-, IGF-1-, TGF-βR1, TGF-βR2 and the EGF-receptor varied significantly. Conclusions In spite of the common cellular origin of these tumours, differences in growth factor receptor expression suggest the existence of different pathways during tumour subtype development." @default.
- W2163478082 created "2016-06-24" @default.
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- W2163478082 date "1998-12-01" @default.
- W2163478082 modified "2023-10-16" @default.
- W2163478082 title "Growth factor receptor expression in human gastroenteropancreatic neuroendocrine tumours" @default.
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- W2163478082 doi "https://doi.org/10.1046/j.1365-2362.1998.00397.x" @default.
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