FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163492589> ?p ?o ?g. }

• W2163492589 endingPage "577" @default.
• W2163492589 startingPage "565" @default.
• W2163492589 abstract "Somatostatin (SS)-binding sites have been demonstrated in human lymphoid tissues and peripheral blood cells. However, not much is known with respect to the SS receptor subtype (sst) expression pattern and the expression of SS itself in the immune system.The aim of this study was to evaluate the mRNA expression of the five known sst (sst(1-5)) in peripheral blood mononuclear cell (sub)populations. Moreover, the expression of the mRNAs encoding SS and the SS-like peptide cortistatin (CST) in immune cell subsets was studied.RT-PCR and quantitative PCR were performed to evaluate sst, SS and CST mRNA expression in cells in the basal or activated state. Fluorescence-activated cell sorter (FACS) analysis using fluorescent SS was performed to visualize sst protein on cell membranes.B- and T-lymphocytes selectively expressed sst(3) mRNA. sst(3) expression in B-lymphocytes was significantly lower compared with T-lymphocytes. Unstimulated, freshly isolated monocytes did not express any sst mRNA. Upon activation, monocytes selectively expressed sst(2) mRNA, whereas T-lymphocyte activation upregulated sst(3) expression. sst(2) mRNA expression on monocytes was confirmed by FACS analysis. B- and T-lymphocytes did not express SS mRNA, while both cell types expressed CST mRNA. CST mRNA expression was downregulated following T-lymphocyte activation.We demonstrate for the first time unequivocally that human peripheral blood B- and T-lymphocytes selectively express sst(3), whereas monocytes do not express sst. However, upon activation, monocytes are induced to express sst(2A). No expression of SS mRNA was detected in any cell type, whereas all cell types expressed CST mRNA. The differential expression of sst and CST mRNA in lymphocytes and monocytes suggests a functional significance for the CST-sst interaction in immune cells, but further studies should be performed to evaluate the significance of sst and CST in these cells." @default.
• W2163492589 created "2016-06-24" @default.
• W2163492589 creator A5006066076 @default.
• W2163492589 creator A5012841131 @default.
• W2163492589 creator A5014138673 @default.
• W2163492589 creator A5016878392 @default.
• W2163492589 creator A5022191812 @default.
• W2163492589 creator A5026793311 @default.
• W2163492589 creator A5072340107 @default.
• W2163492589 date "2004-04-01" @default.
• W2163492589 modified "2023-09-23" @default.
• W2163492589 title "Differential expression of somatostatin receptor subtypes in human peripheral blood mononuclear cell subsets" @default.
• W2163492589 cites W1480909434 @default.
• W2163492589 cites W1539638522 @default.
• W2163492589 cites W1556832516 @default.
• W2163492589 cites W1584038122 @default.
• W2163492589 cites W1589730874 @default.
• W2163492589 cites W1596824624 @default.
• W2163492589 cites W1619707557 @default.
• W2163492589 cites W1624756220 @default.
• W2163492589 cites W1663514770 @default.
• W2163492589 cites W1925868540 @default.
• W2163492589 cites W1970949536 @default.
• W2163492589 cites W1971579834 @default.
• W2163492589 cites W1972776204 @default.
• W2163492589 cites W1981294372 @default.
• W2163492589 cites W1983842165 @default.
• W2163492589 cites W1985107186 @default.
• W2163492589 cites W1986325450 @default.
• W2163492589 cites W1988319336 @default.
• W2163492589 cites W1992184918 @default.
• W2163492589 cites W1993088451 @default.
• W2163492589 cites W1994091239 @default.
• W2163492589 cites W1998795762 @default.
• W2163492589 cites W2009368353 @default.
• W2163492589 cites W2010906418 @default.
• W2163492589 cites W2014371484 @default.
• W2163492589 cites W2021900398 @default.
• W2163492589 cites W2022779726 @default.
• W2163492589 cites W2031484426 @default.
• W2163492589 cites W2033001752 @default.
• W2163492589 cites W2044553538 @default.
• W2163492589 cites W2045783587 @default.
• W2163492589 cites W2048051957 @default.
• W2163492589 cites W2048179918 @default.
• W2163492589 cites W2049362063 @default.
• W2163492589 cites W2054899212 @default.
• W2163492589 cites W2056315084 @default.
• W2163492589 cites W2057628633 @default.
• W2163492589 cites W2060441862 @default.
• W2163492589 cites W2062512861 @default.
• W2163492589 cites W2070721758 @default.
• W2163492589 cites W2071310612 @default.
• W2163492589 cites W2072675860 @default.
• W2163492589 cites W2076561683 @default.
• W2163492589 cites W2076899725 @default.
• W2163492589 cites W2077284175 @default.
• W2163492589 cites W2080232093 @default.
• W2163492589 cites W2106791815 @default.
• W2163492589 cites W2119073596 @default.
• W2163492589 cites W2135778084 @default.
• W2163492589 cites W2138212465 @default.
• W2163492589 cites W2147566707 @default.
• W2163492589 cites W2155016032 @default.
• W2163492589 cites W2163240506 @default.
• W2163492589 cites W2164578725 @default.
• W2163492589 cites W2171999245 @default.
• W2163492589 cites W2240039744 @default.
• W2163492589 cites W2245826107 @default.
• W2163492589 cites W2395604766 @default.
• W2163492589 cites W2415183654 @default.
• W2163492589 cites W2419607759 @default.
• W2163492589 cites W2442741688 @default.
• W2163492589 cites W2411417751 @default.
• W2163492589 doi "https://doi.org/10.1530/eje.0.1500565" @default.
• W2163492589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15080788" @default.
• W2163492589 hasPublicationYear "2004" @default.
• W2163492589 type Work @default.
• W2163492589 sameAs 2163492589 @default.
• W2163492589 citedByCount "57" @default.
• W2163492589 countsByYear W21634925892012 @default.
• W2163492589 countsByYear W21634925892014 @default.
• W2163492589 countsByYear W21634925892015 @default.
• W2163492589 countsByYear W21634925892016 @default.
• W2163492589 countsByYear W21634925892017 @default.
• W2163492589 countsByYear W21634925892018 @default.
• W2163492589 countsByYear W21634925892020 @default.
• W2163492589 countsByYear W21634925892021 @default.
• W2163492589 countsByYear W21634925892022 @default.
• W2163492589 crossrefType "journal-article" @default.
• W2163492589 hasAuthorship W2163492589A5006066076 @default.
• W2163492589 hasAuthorship W2163492589A5012841131 @default.
• W2163492589 hasAuthorship W2163492589A5014138673 @default.
• W2163492589 hasAuthorship W2163492589A5016878392 @default.
• W2163492589 hasAuthorship W2163492589A5022191812 @default.
• W2163492589 hasAuthorship W2163492589A5026793311 @default.
• W2163492589 hasAuthorship W2163492589A5072340107 @default.
• W2163492589 hasBestOaLocation W21634925891 @default.

• next