Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163498387> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2163498387 abstract "Background: Apelin is an endogenous peptide with positive inotropic property secreted by the heart besides other tissues. Plasma apelin levels are altered in chronic heart failure with left ventricular dysfunction. However, the effect of left atrial hemodynamic overload on plasma apelin levels in mitral stenosis (MS) is unknown. In this observational study, we estimated plasma apelin level in MS patients, before and twelve weeks after percutaneous transvenous mitral commissurotomy (PTMC) and compared with plasma brain natriuretic peptide (BNP) levels, mitral valvular pressure gradient and quality of life measure.Methods: Venous blood samples were drawn from 10 MS patients and 10 age-matched controls, with informed consent. Apelin was estimated by competitive ELISA and BNP using an auto-analyzer. PTMC was done by atrial septal puncture and Inoue balloon. Self-administered Kansas City cardiomyopathy questionnaire (KCCQ) was used to assess quality of life. Variables distributed normally were expressed as mean ± S.D. and others as median (interquartile range) and analyzed using appropriate statistical tests. A p-value<0.05 was considered statistically significant.Results: MS patients belonged to NYHA class II & III, had pulmonary artery hypertension but left ventricular ejection fraction>50%. Plasma apelin was lower [320 (167, 515) vs. 570 (415, 680) pg/ml; p=0.028] and BNP level higher [44 (15, 117) vs. 6 (5, 10) pg/ml; p=0.001] in MS patients compared to controls, respectively. PTMC decreased mitral valvular pressure gradient [6.7 (5.0, 8.7) vs. 20.5 (12.4, 27.2) mm of Hg; p=0.012] and improved KCCQ score (84 ± 7 vs. 54 ± 10%; p<0.001) but did not change plasma apelin and BNP levels [330 (192, 465) and 42 (19, 86) pg/ml, respectively].Conclusion: Plasma apelin is depressed and BNP level raised in MS patients. Changes in plasma apelin level may occur slower compared to hemodynamic and functional improvement post PTMC." @default.
- W2163498387 created "2016-06-24" @default.
- W2163498387 creator A5085276353 @default.
- W2163498387 date "2014-01-01" @default.
- W2163498387 modified "2023-09-25" @default.
- W2163498387 title "Effect of Percutaneous Transvenous Mitral Commissurotomy on Plasma Apelin Level in Mitral Stenosis Patients" @default.
- W2163498387 cites W1497027525 @default.
- W2163498387 cites W164951247 @default.
- W2163498387 cites W1966328273 @default.
- W2163498387 cites W2000807269 @default.
- W2163498387 cites W2010618874 @default.
- W2163498387 cites W2014447414 @default.
- W2163498387 cites W2016521491 @default.
- W2163498387 cites W2020905941 @default.
- W2163498387 cites W2029159195 @default.
- W2163498387 cites W2033907514 @default.
- W2163498387 cites W2043185271 @default.
- W2163498387 cites W2051931531 @default.
- W2163498387 cites W2060660919 @default.
- W2163498387 cites W2075105154 @default.
- W2163498387 cites W2083350649 @default.
- W2163498387 cites W2083988122 @default.
- W2163498387 cites W2101099004 @default.
- W2163498387 cites W2107390778 @default.
- W2163498387 cites W2107865655 @default.
- W2163498387 cites W2120772590 @default.
- W2163498387 cites W2123010468 @default.
- W2163498387 cites W2127686513 @default.
- W2163498387 cites W2136953212 @default.
- W2163498387 cites W2139032664 @default.
- W2163498387 cites W2141316227 @default.
- W2163498387 cites W2142011908 @default.
- W2163498387 cites W2152479803 @default.
- W2163498387 cites W2157122261 @default.
- W2163498387 cites W2170793571 @default.
- W2163498387 cites W67314806 @default.
- W2163498387 cites W2411239195 @default.
- W2163498387 doi "https://doi.org/10.4172/2155-9880.1000283" @default.
- W2163498387 hasPublicationYear "2014" @default.
- W2163498387 type Work @default.
- W2163498387 sameAs 2163498387 @default.
- W2163498387 citedByCount "1" @default.
- W2163498387 countsByYear W21634983872015 @default.
- W2163498387 crossrefType "journal-article" @default.
- W2163498387 hasAuthorship W2163498387A5085276353 @default.
- W2163498387 hasBestOaLocation W21634983871 @default.
- W2163498387 hasConcept C126322002 @default.
- W2163498387 hasConcept C164705383 @default.
- W2163498387 hasConcept C170493617 @default.
- W2163498387 hasConcept C2777244179 @default.
- W2163498387 hasConcept C2777543888 @default.
- W2163498387 hasConcept C2779546753 @default.
- W2163498387 hasConcept C2780007028 @default.
- W2163498387 hasConcept C2780703314 @default.
- W2163498387 hasConcept C2780813298 @default.
- W2163498387 hasConcept C71924100 @default.
- W2163498387 hasConceptScore W2163498387C126322002 @default.
- W2163498387 hasConceptScore W2163498387C164705383 @default.
- W2163498387 hasConceptScore W2163498387C170493617 @default.
- W2163498387 hasConceptScore W2163498387C2777244179 @default.
- W2163498387 hasConceptScore W2163498387C2777543888 @default.
- W2163498387 hasConceptScore W2163498387C2779546753 @default.
- W2163498387 hasConceptScore W2163498387C2780007028 @default.
- W2163498387 hasConceptScore W2163498387C2780703314 @default.
- W2163498387 hasConceptScore W2163498387C2780813298 @default.
- W2163498387 hasConceptScore W2163498387C71924100 @default.
- W2163498387 hasIssue "01" @default.
- W2163498387 hasLocation W21634983871 @default.
- W2163498387 hasOpenAccess W2163498387 @default.
- W2163498387 hasPrimaryLocation W21634983871 @default.
- W2163498387 hasRelatedWork W2013781046 @default.
- W2163498387 hasRelatedWork W2034684735 @default.
- W2163498387 hasRelatedWork W2090911341 @default.
- W2163498387 hasRelatedWork W2105358391 @default.
- W2163498387 hasRelatedWork W2168313378 @default.
- W2163498387 hasRelatedWork W2351565909 @default.
- W2163498387 hasRelatedWork W2426470191 @default.
- W2163498387 hasRelatedWork W2441372323 @default.
- W2163498387 hasRelatedWork W3145433713 @default.
- W2163498387 hasRelatedWork W4323237823 @default.
- W2163498387 hasVolume "05" @default.
- W2163498387 isParatext "false" @default.
- W2163498387 isRetracted "false" @default.
- W2163498387 magId "2163498387" @default.
- W2163498387 workType "article" @default.