Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163510354> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2163510354 endingPage "5" @default.
- W2163510354 startingPage "1" @default.
- W2163510354 abstract "Objectives. Long-term assessment of the efficacy and tolerability of subcutaneous abdominal histrelin acetate implants that have been inserted for more than two years. Materials and Methods. Retrospective data collected over a six-year period at a single center from charts of 113 patients who received the subcutaneous abdominal histrelin acetate implant. Results. Following insertion of the first implant, 92.1% and 91.8% of patients had a serum testosterone level of ≤30 ng/dL at 24 and 48 weeks, respectively. Serum testosterone levels remained at <30 ng/dL for 96% of patients at two years and for 100% of patients at 3, 4, and 5 years. The testosterone levels remained significantly less than baseline<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mo stretchy=false>(</mml:mo><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>. Six patients (5.3%) had androgen-independent progression when followed up on the long term, increasing the mean serum PSA at 3, 4, and 5 years to 35.0 µ g/L<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mo stretchy=false>(</mml:mo><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>22</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>, 30.7 µ g/L<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mo stretchy=false>(</mml:mo><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>13</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>, and 132.9 µ g/L<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mo stretchy=false>(</mml:mo><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>8</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>, respectively. The mean serum PSA was significantly greater than baseline during these years<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mo stretchy=false>(</mml:mo><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>. Eight patients (7.1%) experienced minor, but not serious, adverse events from the histrelin acetate. Conclusion. Subcutaneous abdominal histrelin acetate implants are an effective long-term and well-tolerated administration method for treating patients with advanced prostate cancer." @default.
- W2163510354 created "2016-06-24" @default.
- W2163510354 creator A5024266637 @default.
- W2163510354 creator A5045201891 @default.
- W2163510354 creator A5062754000 @default.
- W2163510354 creator A5074665382 @default.
- W2163510354 date "2014-01-01" @default.
- W2163510354 modified "2023-10-14" @default.
- W2163510354 title "Long-Term Efficacy and Tolerability of Abdominal Once-Yearly Histrelin Acetate Subcutaneous Implants in Patients with Advanced Prostate Cancer" @default.
- W2163510354 cites W114049227 @default.
- W2163510354 cites W1592326621 @default.
- W2163510354 cites W1672364870 @default.
- W2163510354 cites W1935718084 @default.
- W2163510354 cites W198709532 @default.
- W2163510354 cites W2037056843 @default.
- W2163510354 cites W2070200481 @default.
- W2163510354 cites W2083094711 @default.
- W2163510354 cites W2091198342 @default.
- W2163510354 cites W2262692246 @default.
- W2163510354 cites W2324774946 @default.
- W2163510354 cites W3021531435 @default.
- W2163510354 cites W4239163741 @default.
- W2163510354 cites W49263098 @default.
- W2163510354 doi "https://doi.org/10.1155/2014/490315" @default.
- W2163510354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4274828" @default.
- W2163510354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25548680" @default.
- W2163510354 hasPublicationYear "2014" @default.
- W2163510354 type Work @default.
- W2163510354 sameAs 2163510354 @default.
- W2163510354 citedByCount "3" @default.
- W2163510354 countsByYear W21635103542017 @default.
- W2163510354 countsByYear W21635103542019 @default.
- W2163510354 countsByYear W21635103542021 @default.
- W2163510354 crossrefType "journal-article" @default.
- W2163510354 hasAuthorship W2163510354A5024266637 @default.
- W2163510354 hasAuthorship W2163510354A5045201891 @default.
- W2163510354 hasAuthorship W2163510354A5062754000 @default.
- W2163510354 hasAuthorship W2163510354A5074665382 @default.
- W2163510354 hasBestOaLocation W21635103541 @default.
- W2163510354 hasConcept C11413529 @default.
- W2163510354 hasConcept C126322002 @default.
- W2163510354 hasConcept C126894567 @default.
- W2163510354 hasConcept C197934379 @default.
- W2163510354 hasConcept C2778375690 @default.
- W2163510354 hasConcept C33923547 @default.
- W2163510354 hasConcept C71924100 @default.
- W2163510354 hasConceptScore W2163510354C11413529 @default.
- W2163510354 hasConceptScore W2163510354C126322002 @default.
- W2163510354 hasConceptScore W2163510354C126894567 @default.
- W2163510354 hasConceptScore W2163510354C197934379 @default.
- W2163510354 hasConceptScore W2163510354C2778375690 @default.
- W2163510354 hasConceptScore W2163510354C33923547 @default.
- W2163510354 hasConceptScore W2163510354C71924100 @default.
- W2163510354 hasLocation W21635103541 @default.
- W2163510354 hasLocation W21635103542 @default.
- W2163510354 hasLocation W21635103543 @default.
- W2163510354 hasLocation W21635103544 @default.
- W2163510354 hasLocation W21635103545 @default.
- W2163510354 hasOpenAccess W2163510354 @default.
- W2163510354 hasPrimaryLocation W21635103541 @default.
- W2163510354 hasRelatedWork W1991176685 @default.
- W2163510354 hasRelatedWork W2023520015 @default.
- W2163510354 hasRelatedWork W2091019473 @default.
- W2163510354 hasRelatedWork W2118368078 @default.
- W2163510354 hasRelatedWork W2148656812 @default.
- W2163510354 hasRelatedWork W2151556292 @default.
- W2163510354 hasRelatedWork W2354744981 @default.
- W2163510354 hasRelatedWork W2392413698 @default.
- W2163510354 hasRelatedWork W2409130183 @default.
- W2163510354 hasRelatedWork W2118673085 @default.
- W2163510354 hasVolume "2014" @default.
- W2163510354 isParatext "false" @default.
- W2163510354 isRetracted "false" @default.
- W2163510354 magId "2163510354" @default.
- W2163510354 workType "article" @default.