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- W2163536888 startingPage "359" @default.
- W2163536888 abstract "Obesity is a major health problem worldwide; it is associated with more than 30 medical conditions and is a leading cause of unnecessary deaths. Adipose tissue not only acts as an energy store, but also behaves like an endocrine organ, synthesising and secreting numerous hormones and cytokines. Angiotensin II (ANG II) is the biologically active component of the renin-angiotensin system (RAS). The RAS is present in adipose tissue and evidence suggests that ANG II is intimately linked to obesity. Indeed, ANG II increases fat cell growth and differentiation, increases synthesis, uptake and storage of fatty acids and triglycerides and possibly inhibits lipolysis. Evidence obtained using genetically modified animals has shown that the amount of body fat is directly related to the amount of ANG II, i.e., animals with low levels of ANG II have reduced fat stores while animals with excessive ANG II have increased fat stores. In humans, epidemiological evidence has shown that body fat is correlated with angiotensinogen, a precursor of ANG II, or other components of the RAS. Furthermore, blocking the production and/or actions of ANG II with drugs or natural substances decreases body fat. The decrease in body fat caused by such treatments predominantly occurs in abdominal fat depots and appears to be independent of energy intake and digestibility. Clearly, ANG II has an important role in the accumulation of body fat and the possibility exists that treatment of obesity will be enhanced by the use of natural or synthetic substances that interfere with ANG II." @default.
- W2163536888 created "2016-06-24" @default.
- W2163536888 creator A5004927512 @default.
- W2163536888 creator A5018868735 @default.
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- W2163536888 creator A5022384395 @default.
- W2163536888 creator A5028862826 @default.
- W2163536888 creator A5061809268 @default.
- W2163536888 date "2007-01-01" @default.
- W2163536888 modified "2023-09-24" @default.
- W2163536888 title "The problem of obesity: is there a role for antagonists of the renin-angiotensin system?" @default.
- W2163536888 cites W1539862553 @default.
- W2163536888 cites W160011949 @default.
- W2163536888 cites W1749348042 @default.
- W2163536888 cites W1840127740 @default.
- W2163536888 cites W1893788133 @default.
- W2163536888 cites W1894627265 @default.
- W2163536888 cites W1907219612 @default.
- W2163536888 cites W1926509225 @default.
- W2163536888 cites W1965120293 @default.
- W2163536888 cites W1972990982 @default.
- W2163536888 cites W1974201641 @default.
- W2163536888 cites W1974892271 @default.
- W2163536888 cites W1975561886 @default.
- W2163536888 cites W1975898092 @default.
- W2163536888 cites W1976434318 @default.
- W2163536888 cites W1978504634 @default.
- W2163536888 cites W1982143871 @default.
- W2163536888 cites W1983801758 @default.
- W2163536888 cites W1985937888 @default.
- W2163536888 cites W1986473930 @default.
- W2163536888 cites W1989603944 @default.
- W2163536888 cites W1991694904 @default.
- W2163536888 cites W1994982633 @default.
- W2163536888 cites W1997047615 @default.
- W2163536888 cites W1998399956 @default.
- W2163536888 cites W2002008715 @default.
- W2163536888 cites W2002519246 @default.
- W2163536888 cites W2003695754 @default.
- W2163536888 cites W2005674716 @default.
- W2163536888 cites W2007686456 @default.
- W2163536888 cites W2009512529 @default.
- W2163536888 cites W2018431713 @default.
- W2163536888 cites W2019856196 @default.
- W2163536888 cites W2020571025 @default.
- W2163536888 cites W2023291377 @default.
- W2163536888 cites W2027494269 @default.
- W2163536888 cites W2029178933 @default.
- W2163536888 cites W2030464452 @default.
- W2163536888 cites W2031204813 @default.
- W2163536888 cites W2031238420 @default.
- W2163536888 cites W2031370342 @default.
- W2163536888 cites W2031790264 @default.
- W2163536888 cites W2033898921 @default.
- W2163536888 cites W2037748805 @default.
- W2163536888 cites W2039811822 @default.
- W2163536888 cites W2039840283 @default.
- W2163536888 cites W2042706232 @default.
- W2163536888 cites W2043028234 @default.
- W2163536888 cites W2045930196 @default.
- W2163536888 cites W2046942614 @default.
- W2163536888 cites W2047591801 @default.
- W2163536888 cites W2047922146 @default.
- W2163536888 cites W2048895906 @default.
- W2163536888 cites W2049618589 @default.
- W2163536888 cites W2049773210 @default.
- W2163536888 cites W2058410894 @default.
- W2163536888 cites W2061994091 @default.
- W2163536888 cites W2064387923 @default.
- W2163536888 cites W2065163855 @default.
- W2163536888 cites W2069497802 @default.
- W2163536888 cites W2075530566 @default.
- W2163536888 cites W2076540956 @default.
- W2163536888 cites W2081393100 @default.
- W2163536888 cites W2081609899 @default.
- W2163536888 cites W2086191204 @default.
- W2163536888 cites W2091296420 @default.
- W2163536888 cites W2098740299 @default.
- W2163536888 cites W2099376985 @default.
- W2163536888 cites W2099643598 @default.
- W2163536888 cites W2099655870 @default.
- W2163536888 cites W2102313291 @default.
- W2163536888 cites W2102675343 @default.
- W2163536888 cites W2104340865 @default.
- W2163536888 cites W2105542129 @default.
- W2163536888 cites W2107595729 @default.
- W2163536888 cites W2108435949 @default.
- W2163536888 cites W2109355862 @default.
- W2163536888 cites W2109667695 @default.
- W2163536888 cites W2111378085 @default.
- W2163536888 cites W2113273743 @default.
- W2163536888 cites W2115414014 @default.
- W2163536888 cites W2116273731 @default.
- W2163536888 cites W2119527577 @default.
- W2163536888 cites W2125340464 @default.
- W2163536888 cites W2125344994 @default.
- W2163536888 cites W2130618859 @default.
- W2163536888 cites W2130755410 @default.