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• W2163546475 abstract "Nobiletin is a polymethoxyflavonoid with a remarkable antiproliferative effect. In order to overcome its low aqueous solubility and chemical instability, the use of nanoparticles as carriers has been proposed. This study explores the possibility of binding nobiletin to chitosan nanoparticles, as well as to evaluate their antiproliferative activity. The association and loading efficiencies are 69.1% and 7.0%, respectively. The formation of an imine bond between chitosan amine groups and the carbonyl group of nobiletin, via Schiff-base, is proposed. Nobiletin-loaded chitosan nanoparticles exhibit considerable inhibition (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mtext>I</mml:mtext><mml:msub><mml:mtext>C</mml:mtext><mml:mrow><mml:mn>50</mml:mn></mml:mrow></mml:msub><mml:mo>=</mml:mo><mml:mn>8</mml:mn></mml:mrow></mml:math> μ g/mL) of cancerous cells, revealing their great potential for applications in cancer chemotherapy." @default.
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• W2163546475 date "2012-01-01" @default.
• W2163546475 modified "2023-10-16" @default.
• W2163546475 title "Characterization and Antiproliferative Activity of Nobiletin-Loaded Chitosan Nanoparticles" @default.
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• W2163546475 doi "https://doi.org/10.1155/2012/265161" @default.
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