FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163553404> ?p ?o ?g. }

• W2163553404 endingPage "381" @default.
• W2163553404 startingPage "371" @default.
• W2163553404 abstract "The hospital records of 78 patients who underwent surgical therapy for fungal infections of the central nervous system (CNS) between 1964 and 1984 are summarized. Nine different fungal types were identified, but Coccidioides immitis and Cryptococcus neoformans accounted for most (67.1%) of the infections. A variety of clinical syndromes were seen, including chronic basal meningitis (45 patients), intracranial mass lesions (12 patients), and communicating hydrocephalus (six patients). Thirteen patients had rhinocerebral forms of fungal infection, and two presented with spinal involvement. Delays in diagnosis were frequent and ranged from 2 months to 11 years. In 31 patients the CNS lesion was the first indication of a fungal infection, and lesion biopsy or cerebrospinal fluid (CSF) examination confirmed the diagnosis. A total of 144 surgical procedures were carried out, including lesion biopsy or excision in 13 patients, primary CSF shunting in 22, and placement of an Ommaya reservoir for administration of intraventricular or intracisternal antifungal agents in 48. All patients received parenteral and, in some cases, intrathecal or oral antifungal chemotherapy in addition to surgical therapy. Overall mortality was 43.6% (34 deaths). With prompt diagnosis and treatment, the mortality rate was 39% whereas, when appropriate treatment was delayed, the mortality rate was 64%. An additional 14 surviving patients (17.9%) exhibited permanent morbidity due to neurological deficits, seizure disorders, or renal toxicity following treatment with amphotericin B. The combined mortality and morbidity rate was 62.8%. Clinical symptoms were resolved completely in 29 patients, although in 10 evidence of disease persisted and chemotherapy was continued. Fungal infections of the CNS are being recognized with increased frequency. It is suggested that a high index of suspicion, aggressive attempts to obtain a diagnosis, and early and vigorous therapy may reduce the unfortunate outcome seen in a relatively high proportion of patients with CNS fungal infections." @default.
• W2163553404 created "2016-06-24" @default.
• W2163553404 creator A5005363995 @default.
• W2163553404 creator A5047963283 @default.
• W2163553404 creator A5082298195 @default.
• W2163553404 date "1985-09-01" @default.
• W2163553404 modified "2023-10-13" @default.
• W2163553404 title "Surgical treatment for fungal infections in the central nervous system" @default.
• W2163553404 cites W1486265523 @default.
• W2163553404 cites W1515434773 @default.
• W2163553404 cites W1534546565 @default.
• W2163553404 cites W1801339192 @default.
• W2163553404 cites W1951393074 @default.
• W2163553404 cites W1962659169 @default.
• W2163553404 cites W196483848 @default.
• W2163553404 cites W1973283857 @default.
• W2163553404 cites W1974366311 @default.
• W2163553404 cites W1979290878 @default.
• W2163553404 cites W1980840811 @default.
• W2163553404 cites W1981488282 @default.
• W2163553404 cites W1987301672 @default.
• W2163553404 cites W1988414432 @default.
• W2163553404 cites W1991581828 @default.
• W2163553404 cites W1995088186 @default.
• W2163553404 cites W1999403324 @default.
• W2163553404 cites W2000177149 @default.
• W2163553404 cites W2002205080 @default.
• W2163553404 cites W2002773092 @default.
• W2163553404 cites W2006872597 @default.
• W2163553404 cites W2024244117 @default.
• W2163553404 cites W2025804022 @default.
• W2163553404 cites W2027151083 @default.
• W2163553404 cites W2029325254 @default.
• W2163553404 cites W2032203162 @default.
• W2163553404 cites W2033991588 @default.
• W2163553404 cites W2036560123 @default.
• W2163553404 cites W2037158180 @default.
• W2163553404 cites W2039862914 @default.
• W2163553404 cites W2039909749 @default.
• W2163553404 cites W2040999360 @default.
• W2163553404 cites W2041843816 @default.
• W2163553404 cites W2048216135 @default.
• W2163553404 cites W2050587054 @default.
• W2163553404 cites W2053231860 @default.
• W2163553404 cites W2055885153 @default.
• W2163553404 cites W2059361255 @default.
• W2163553404 cites W2062182251 @default.
• W2163553404 cites W2062270622 @default.
• W2163553404 cites W2064359428 @default.
• W2163553404 cites W2070474970 @default.
• W2163553404 cites W2071517638 @default.
• W2163553404 cites W2078030342 @default.
• W2163553404 cites W2079782230 @default.
• W2163553404 cites W2082829263 @default.
• W2163553404 cites W2087302450 @default.
• W2163553404 cites W2093116491 @default.
• W2163553404 cites W2093307167 @default.
• W2163553404 cites W2110825307 @default.
• W2163553404 cites W2115617908 @default.
• W2163553404 cites W2129132163 @default.
• W2163553404 cites W2134175336 @default.
• W2163553404 cites W2137541104 @default.
• W2163553404 cites W2140362581 @default.
• W2163553404 cites W2155732954 @default.
• W2163553404 cites W2156272551 @default.
• W2163553404 cites W2157112413 @default.
• W2163553404 cites W2163347759 @default.
• W2163553404 cites W2166353565 @default.
• W2163553404 cites W2261204399 @default.
• W2163553404 cites W2325639628 @default.
• W2163553404 cites W2326171482 @default.
• W2163553404 cites W2626572345 @default.
• W2163553404 cites W268788583 @default.
• W2163553404 cites W4251725014 @default.
• W2163553404 cites W4252449475 @default.
• W2163553404 cites W89355478 @default.
• W2163553404 doi "https://doi.org/10.3171/jns.1985.63.3.0371" @default.
• W2163553404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4020464" @default.
• W2163553404 hasPublicationYear "1985" @default.
• W2163553404 type Work @default.
• W2163553404 sameAs 2163553404 @default.
• W2163553404 citedByCount "70" @default.
• W2163553404 countsByYear W21635534042012 @default.
• W2163553404 countsByYear W21635534042013 @default.
• W2163553404 countsByYear W21635534042014 @default.
• W2163553404 countsByYear W21635534042015 @default.
• W2163553404 countsByYear W21635534042017 @default.
• W2163553404 countsByYear W21635534042018 @default.
• W2163553404 countsByYear W21635534042019 @default.
• W2163553404 countsByYear W21635534042020 @default.
• W2163553404 countsByYear W21635534042021 @default.
• W2163553404 crossrefType "journal-article" @default.
• W2163553404 hasAuthorship W2163553404A5005363995 @default.
• W2163553404 hasAuthorship W2163553404A5047963283 @default.
• W2163553404 hasAuthorship W2163553404A5082298195 @default.
• W2163553404 hasBestOaLocation W21635534041 @default.
• W2163553404 hasConcept C141071460 @default.
• W2163553404 hasConcept C16005928 @default.

• next