FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163569985> ?p ?o ?g. }

• W2163569985 endingPage "847" @default.
• W2163569985 startingPage "843" @default.
• W2163569985 abstract "The efficacy and safety of doxepin (DXP) 6mg tablets were evaluated in healthy adults in a model of transient insomnia.This was a randomized, double-blind, parallel-group, placebo-controlled study in healthy adults using a model of transient insomnia. A first-night effect combined with a 3-h phase advance was implemented to induce transient insomnia in healthy adults. Subjects received a single night time dose of placebo (PBO; N=282) or DXP 6mg (N=283) in a sleep laboratory. Efficacy was evaluated objectively (polysomnography; PSG) and subjectively (morning questionnaire). Consistent with the model utilized, the primary endpoint was latency to persistent sleep (LPS); secondary PSG endpoints included wake after sleep onset (WASO; key secondary endpoint), total sleep time (TST), wake time after sleep (WTAS) and sleep efficiency (SE; overall, by quarter of the night and hourly); secondary subjective endpoints included latency to sleep onset (LSO), subjective WASO (sWASO), subjective TST (sTST) and sleep quality.DXP 6mg demonstrated statistically significant improvements in LPS (13min decrease versus PBO; p<0.0001), WASO (39min less than PBO; p<0.0001), TST (51min more than PBO; p<0.0001), WTAS (p<0.0001), overall SE (p<0.0001), SE in each quarter of the night (p<0.0001) and SE in each of the 8h (p⩽0.0003), all versus PBO. Additionally, DXP 6mg significantly improved subjective variables including LSO (p<0.0001), sWASO (p=0.0063), sTST (p<0.0001), and sleep quality (p=0.0004), versus PBO. There was no consistent evidence of next-day residual sedation and also minor sleep stages alterations. The incidence of adverse events was comparable to placebo.In this model of transient insomnia, DXP 6mg demonstrated significant improvements in sleep onset, sleep maintenance, sleep duration and sleep quality, and also appeared to reduce early morning awakenings. These data suggest that DXP 6mg may be effective and well tolerated in adults experiencing transient insomnia." @default.
• W2163569985 created "2016-06-24" @default.
• W2163569985 creator A5011791624 @default.
• W2163569985 creator A5011832419 @default.
• W2163569985 creator A5029085075 @default.
• W2163569985 creator A5071948816 @default.
• W2163569985 creator A5080728785 @default.
• W2163569985 creator A5083676256 @default.
• W2163569985 creator A5087288001 @default.
• W2163569985 creator A5089277282 @default.
• W2163569985 date "2010-10-01" @default.
• W2163569985 modified "2023-10-17" @default.
• W2163569985 title "Efficacy and safety of doxepin 6 mg in a model of transient insomnia" @default.
• W2163569985 cites W15424833 @default.
• W2163569985 cites W2007188568 @default.
• W2163569985 cites W2066935851 @default.
• W2163569985 cites W2091908519 @default.
• W2163569985 cites W2137143812 @default.
• W2163569985 cites W73680102 @default.
• W2163569985 doi "https://doi.org/10.1016/j.sleep.2010.07.006" @default.
• W2163569985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20817598" @default.
• W2163569985 hasPublicationYear "2010" @default.
• W2163569985 type Work @default.
• W2163569985 sameAs 2163569985 @default.
• W2163569985 citedByCount "27" @default.
• W2163569985 countsByYear W21635699852012 @default.
• W2163569985 countsByYear W21635699852013 @default.
• W2163569985 countsByYear W21635699852014 @default.
• W2163569985 countsByYear W21635699852015 @default.
• W2163569985 countsByYear W21635699852016 @default.
• W2163569985 countsByYear W21635699852018 @default.
• W2163569985 countsByYear W21635699852020 @default.
• W2163569985 countsByYear W21635699852021 @default.
• W2163569985 countsByYear W21635699852022 @default.
• W2163569985 countsByYear W21635699852023 @default.
• W2163569985 crossrefType "journal-article" @default.
• W2163569985 hasAuthorship W2163569985A5011791624 @default.
• W2163569985 hasAuthorship W2163569985A5011832419 @default.
• W2163569985 hasAuthorship W2163569985A5029085075 @default.
• W2163569985 hasAuthorship W2163569985A5071948816 @default.
• W2163569985 hasAuthorship W2163569985A5080728785 @default.
• W2163569985 hasAuthorship W2163569985A5083676256 @default.
• W2163569985 hasAuthorship W2163569985A5087288001 @default.
• W2163569985 hasAuthorship W2163569985A5089277282 @default.
• W2163569985 hasConcept C126322002 @default.
• W2163569985 hasConcept C142724271 @default.
• W2163569985 hasConcept C1513209611 @default.
• W2163569985 hasConcept C168563851 @default.
• W2163569985 hasConcept C19720800 @default.
• W2163569985 hasConcept C203092338 @default.
• W2163569985 hasConcept C204787440 @default.
• W2163569985 hasConcept C27081682 @default.
• W2163569985 hasConcept C2777747321 @default.
• W2163569985 hasConcept C2778205975 @default.
• W2163569985 hasConcept C2781053850 @default.
• W2163569985 hasConcept C2781210498 @default.
• W2163569985 hasConcept C2781326671 @default.
• W2163569985 hasConcept C2910380747 @default.
• W2163569985 hasConcept C2983189541 @default.
• W2163569985 hasConcept C42219234 @default.
• W2163569985 hasConcept C63759246 @default.
• W2163569985 hasConcept C71924100 @default.
• W2163569985 hasConcept C98274493 @default.
• W2163569985 hasConceptScore W2163569985C126322002 @default.
• W2163569985 hasConceptScore W2163569985C142724271 @default.
• W2163569985 hasConceptScore W2163569985C1513209611 @default.
• W2163569985 hasConceptScore W2163569985C168563851 @default.
• W2163569985 hasConceptScore W2163569985C19720800 @default.
• W2163569985 hasConceptScore W2163569985C203092338 @default.
• W2163569985 hasConceptScore W2163569985C204787440 @default.
• W2163569985 hasConceptScore W2163569985C27081682 @default.
• W2163569985 hasConceptScore W2163569985C2777747321 @default.
• W2163569985 hasConceptScore W2163569985C2778205975 @default.
• W2163569985 hasConceptScore W2163569985C2781053850 @default.
• W2163569985 hasConceptScore W2163569985C2781210498 @default.
• W2163569985 hasConceptScore W2163569985C2781326671 @default.
• W2163569985 hasConceptScore W2163569985C2910380747 @default.
• W2163569985 hasConceptScore W2163569985C2983189541 @default.
• W2163569985 hasConceptScore W2163569985C42219234 @default.
• W2163569985 hasConceptScore W2163569985C63759246 @default.
• W2163569985 hasConceptScore W2163569985C71924100 @default.
• W2163569985 hasConceptScore W2163569985C98274493 @default.
• W2163569985 hasIssue "9" @default.
• W2163569985 hasLocation W21635699851 @default.
• W2163569985 hasLocation W21635699852 @default.
• W2163569985 hasOpenAccess W2163569985 @default.
• W2163569985 hasPrimaryLocation W21635699851 @default.
• W2163569985 hasRelatedWork W2036316219 @default.
• W2163569985 hasRelatedWork W2163569985 @default.
• W2163569985 hasRelatedWork W2166178106 @default.
• W2163569985 hasRelatedWork W2348551484 @default.
• W2163569985 hasRelatedWork W2385793114 @default.
• W2163569985 hasRelatedWork W2516714367 @default.
• W2163569985 hasRelatedWork W2605781031 @default.
• W2163569985 hasRelatedWork W3029892802 @default.
• W2163569985 hasRelatedWork W3109891723 @default.
• W2163569985 hasRelatedWork W4306711120 @default.
• W2163569985 hasVolume "11" @default.

• next