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• W2163574436 abstract "Piscidin-1, a 22-residue cationic peptide isolated from mast cells of a hybrid striped bass, has potent antimicrobial activities against both gram-positive and -negative bacteria. To date, there is no report of its antitumor activity on any tumor cell lines. In this study, we examined the antitumor activity of a synthetic piscidin-1 peptide against several human cancer cell lines using an MTS assay and soft-agar colony-formation assay. We found that a low dose of piscidin induces both apoptosis and necrosis in HT1080 cells, as shown by annexin-V/propidium iodide and acridine orange/ethidium bromide staining, and triggers a necrotic cell death pathway in a short period with high-dose treatment. The destruction of cell membranes by piscidin-1 was demonstrated by transmission electron microscopy. Furthermore, piscidin-1 also inhibits the migration of HT1080 cells in a dose-dependent manner. This study provides the first evidence of the anticancer activity of the antimicrobial peptide, piscidin-1, with potential implications for the treatment of cancer." @default.
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• W2163574436 date "2012-05-01" @default.
• W2163574436 modified "2023-10-16" @default.
• W2163574436 title "Piscidin-1, an Antimicrobial Peptide from Fish (Hybrid Striped Bass<i>Morone saxatilis</i>x<i>M. chrysops</i>), Induces Apoptotic and Necrotic Activity in HT1080 Cells" @default.
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• W2163574436 doi "https://doi.org/10.2108/zsj.29.327" @default.
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