FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163576684> ?p ?o ?g. }

• W2163576684 abstract "Increased resistance by Plasmodium falciparum parasites led to the withdrawal of the antimalarial drugs chloroquine and sulphadoxine-pyrimethamine in Ethiopia. Since 2004 artemether-lumefantrine has served to treat uncomplicated P. falciparum malaria. However, increasing reports on delayed parasite clearance to artemisinin opens up a new challenge in anti-malarial therapy. With the complete withdrawal of CQ for the treatment of Plasmodium falciparum malaria, this study assessed the evolution of CQ resistance by investigating the prevalence of mutant alleles in the pfmdr1 and pfcrt genes in P. falciparum and pvmdr1 gene in Plasmodium vivax in Southern and Eastern Ethiopia.Of the 1,416 febrile patients attending primary health facilities in Southern Ethiopia, 329 febrile patients positive for P. falciparum or P. vivax were recruited. Similarly of the 1,304 febrile patients from Eastern Ethiopia, 81 febrile patients positive for P. falciparum or P. vivax were included in the study. Of the 410 finger prick blood samples collected from malaria patients, we used direct sequencing to investigate the prevalence of mutations in pfcrt and pfmdr1. This included determining the gene copy number in pfmdr1 in 195 P. falciparum clinical isolates, and mutations in the pvmdr1 locus in 215 P. vivax clinical isolates.The pfcrt K76 CQ-sensitive allele was observed in 84.1% of the investigated P.falciparum clinical isolates. The pfcrt double mutations (K76T and C72S) were observed less than 3%. The pfcrt SVMNT haplotype was also found to be present in clinical isolates from Ethiopia. The pfcrt CVMNK-sensitive haplotypes were frequently observed (95.9%). The pfmdr1 mutation N86Y was observed only in 14.9% compared to 85.1% of the clinical isolates that carried sensitive alleles. Also, the sensitive pfmdr1 Y184 allele was more common, in 94.9% of clinical isolates. None of the investigated P. falciparum clinical isolates carried S1034C, N1042D and D1246Y pfmdr1 polymorphisms. All investigated P. falciparum clinical isolates from Southern and Eastern Ethiopia carried only a single copy of the mutant pfmdr1 gene.The study reports for the first time the return of chloroquine sensitive P. falciparum in Ethiopia. These findings support the rationale for the use of CQ-based combination drugs as a possible future alternative." @default.
• W2163576684 created "2016-06-24" @default.
• W2163576684 creator A5016630495 @default.
• W2163576684 creator A5053655989 @default.
• W2163576684 creator A5064904760 @default.
• W2163576684 creator A5069606161 @default.
• W2163576684 creator A5071548065 @default.
• W2163576684 creator A5074953709 @default.
• W2163576684 creator A5079299729 @default.
• W2163576684 creator A5082702781 @default.
• W2163576684 date "2014-06-25" @default.
• W2163576684 modified "2023-10-15" @default.
• W2163576684 title "Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia" @default.
• W2163576684 cites W1672791537 @default.
• W2163576684 cites W1922732464 @default.
• W2163576684 cites W1968011802 @default.
• W2163576684 cites W1969201300 @default.
• W2163576684 cites W1986021682 @default.
• W2163576684 cites W1994373940 @default.
• W2163576684 cites W1998740793 @default.
• W2163576684 cites W2003819157 @default.
• W2163576684 cites W2014412078 @default.
• W2163576684 cites W2019038471 @default.
• W2163576684 cites W2022706035 @default.
• W2163576684 cites W2025054505 @default.
• W2163576684 cites W2025403240 @default.
• W2163576684 cites W2028891315 @default.
• W2163576684 cites W2046386353 @default.
• W2163576684 cites W2063969257 @default.
• W2163576684 cites W2080956225 @default.
• W2163576684 cites W2083522771 @default.
• W2163576684 cites W2084940050 @default.
• W2163576684 cites W2094356691 @default.
• W2163576684 cites W2097263871 @default.
• W2163576684 cites W2098016374 @default.
• W2163576684 cites W2100077167 @default.
• W2163576684 cites W2103942357 @default.
• W2163576684 cites W2104536143 @default.
• W2163576684 cites W2107071499 @default.
• W2163576684 cites W2107277218 @default.
• W2163576684 cites W2107362807 @default.
• W2163576684 cites W2110269548 @default.
• W2163576684 cites W2112684172 @default.
• W2163576684 cites W2112893129 @default.
• W2163576684 cites W2118631269 @default.
• W2163576684 cites W2122382989 @default.
• W2163576684 cites W2122827495 @default.
• W2163576684 cites W2124839325 @default.
• W2163576684 cites W2131095198 @default.
• W2163576684 cites W2132923209 @default.
• W2163576684 cites W2137636253 @default.
• W2163576684 cites W2139331196 @default.
• W2163576684 cites W2157571159 @default.
• W2163576684 cites W2157765820 @default.
• W2163576684 cites W2158780951 @default.
• W2163576684 cites W2161308783 @default.
• W2163576684 cites W2161311583 @default.
• W2163576684 cites W2163644520 @default.
• W2163576684 cites W2164294574 @default.
• W2163576684 cites W2165565059 @default.
• W2163576684 cites W2167691587 @default.
• W2163576684 cites W2168267873 @default.
• W2163576684 cites W2171252270 @default.
• W2163576684 cites W2217354070 @default.
• W2163576684 cites W2376584008 @default.
• W2163576684 cites W2401730911 @default.
• W2163576684 doi "https://doi.org/10.1186/1475-2875-13-244" @default.
• W2163576684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4230645" @default.
• W2163576684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24964730" @default.
• W2163576684 hasPublicationYear "2014" @default.
• W2163576684 type Work @default.
• W2163576684 sameAs 2163576684 @default.
• W2163576684 citedByCount "66" @default.
• W2163576684 countsByYear W21635766842014 @default.
• W2163576684 countsByYear W21635766842015 @default.
• W2163576684 countsByYear W21635766842016 @default.
• W2163576684 countsByYear W21635766842017 @default.
• W2163576684 countsByYear W21635766842018 @default.
• W2163576684 countsByYear W21635766842019 @default.
• W2163576684 countsByYear W21635766842020 @default.
• W2163576684 countsByYear W21635766842021 @default.
• W2163576684 countsByYear W21635766842022 @default.
• W2163576684 countsByYear W21635766842023 @default.
• W2163576684 crossrefType "journal-article" @default.
• W2163576684 hasAuthorship W2163576684A5016630495 @default.
• W2163576684 hasAuthorship W2163576684A5053655989 @default.
• W2163576684 hasAuthorship W2163576684A5064904760 @default.
• W2163576684 hasAuthorship W2163576684A5069606161 @default.
• W2163576684 hasAuthorship W2163576684A5071548065 @default.
• W2163576684 hasAuthorship W2163576684A5074953709 @default.
• W2163576684 hasAuthorship W2163576684A5079299729 @default.
• W2163576684 hasAuthorship W2163576684A5082702781 @default.
• W2163576684 hasBestOaLocation W21635766841 @default.
• W2163576684 hasConcept C104317684 @default.
• W2163576684 hasConcept C114851261 @default.
• W2163576684 hasConcept C159047783 @default.
• W2163576684 hasConcept C180754005 @default.
• W2163576684 hasConcept C190612196 @default.
• W2163576684 hasConcept C197754878 @default.
• W2163576684 hasConcept C203014093 @default.

• next