FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163592009> ?p ?o ?g. }

• W2163592009 endingPage "e1001034" @default.
• W2163592009 startingPage "e1001034" @default.
• W2163592009 abstract "Embryonic stem cells (ESC) have the potential to self-renew indefinitely and to differentiate into any of the three germ layers. The molecular mechanisms for self-renewal, maintenance of pluripotency and lineage specification are poorly understood, but recent results point to a key role for epigenetic mechanisms. In this study, we focus on quantifying the impact of histone 3 acetylation (H3K9,14ac) on gene expression in murine embryonic stem cells. We analyze genome-wide histone acetylation patterns and gene expression profiles measured over the first five days of cell differentiation triggered by silencing Nanog, a key transcription factor in ESC regulation. We explore the temporal and spatial dynamics of histone acetylation data and its correlation with gene expression using supervised and unsupervised statistical models. On a genome-wide scale, changes in acetylation are significantly correlated to changes in mRNA expression and, surprisingly, this coherence increases over time. We quantify the predictive power of histone acetylation for gene expression changes in a balanced cross-validation procedure. In an in-depth study we focus on genes central to the regulatory network of Mouse ESC, including those identified in a recent genome-wide RNAi screen and in the PluriNet, a computationally derived stem cell signature. We find that compared to the rest of the genome, ESC-specific genes show significantly more acetylation signal and a much stronger decrease in acetylation over time, which is often not reflected in a concordant expression change. These results shed light on the complexity of the relationship between histone acetylation and gene expression and are a step forward to dissect the multilayer regulatory mechanisms that determine stem cell fate." @default.
• W2163592009 created "2016-06-24" @default.
• W2163592009 creator A5005386059 @default.
• W2163592009 creator A5025250742 @default.
• W2163592009 creator A5028794948 @default.
• W2163592009 creator A5035398709 @default.
• W2163592009 creator A5083151857 @default.
• W2163592009 date "2010-12-16" @default.
• W2163592009 modified "2023-10-18" @default.
• W2163592009 title "Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-Depleted Murine Embryonic Stem Cells" @default.
• W2163592009 cites W1480376833 @default.
• W2163592009 cites W1876024155 @default.
• W2163592009 cites W1964269089 @default.
• W2163592009 cites W1965428318 @default.
• W2163592009 cites W1968931043 @default.
• W2163592009 cites W1971445167 @default.
• W2163592009 cites W1975200987 @default.
• W2163592009 cites W1979245454 @default.
• W2163592009 cites W1990512452 @default.
• W2163592009 cites W1997986614 @default.
• W2163592009 cites W2005928381 @default.
• W2163592009 cites W2007497552 @default.
• W2163592009 cites W2014426141 @default.
• W2163592009 cites W2014937237 @default.
• W2163592009 cites W2015396326 @default.
• W2163592009 cites W2017840637 @default.
• W2163592009 cites W2029903254 @default.
• W2163592009 cites W2042249135 @default.
• W2163592009 cites W2042633640 @default.
• W2163592009 cites W2050594481 @default.
• W2163592009 cites W2058521801 @default.
• W2163592009 cites W2059685661 @default.
• W2163592009 cites W2066911215 @default.
• W2163592009 cites W2069328568 @default.
• W2163592009 cites W2069717852 @default.
• W2163592009 cites W2073727170 @default.
• W2163592009 cites W2083245183 @default.
• W2163592009 cites W2084521437 @default.
• W2163592009 cites W2096501714 @default.
• W2163592009 cites W2103017472 @default.
• W2163592009 cites W2103302926 @default.
• W2163592009 cites W2104364444 @default.
• W2163592009 cites W2107575419 @default.
• W2163592009 cites W2109407861 @default.
• W2163592009 cites W2110015307 @default.
• W2163592009 cites W2114803986 @default.
• W2163592009 cites W2117812871 @default.
• W2163592009 cites W2122215608 @default.
• W2163592009 cites W2124486107 @default.
• W2163592009 cites W2126731419 @default.
• W2163592009 cites W2127081697 @default.
• W2163592009 cites W2130410032 @default.
• W2163592009 cites W2133938268 @default.
• W2163592009 cites W2140116490 @default.
• W2163592009 cites W2141171810 @default.
• W2163592009 cites W2145444336 @default.
• W2163592009 cites W2147214562 @default.
• W2163592009 cites W2153424791 @default.
• W2163592009 cites W2158610627 @default.
• W2163592009 cites W2160697532 @default.
• W2163592009 cites W2161224111 @default.
• W2163592009 cites W2161827767 @default.
• W2163592009 cites W2164216268 @default.
• W2163592009 cites W2164307166 @default.
• W2163592009 cites W2911964244 @default.
• W2163592009 cites W4212883601 @default.
• W2163592009 doi "https://doi.org/10.1371/journal.pcbi.1001034" @default.
• W2163592009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3002996" @default.
• W2163592009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21187909" @default.
• W2163592009 hasPublicationYear "2010" @default.
• W2163592009 type Work @default.
• W2163592009 sameAs 2163592009 @default.
• W2163592009 citedByCount "21" @default.
• W2163592009 countsByYear W21635920092012 @default.
• W2163592009 countsByYear W21635920092013 @default.
• W2163592009 countsByYear W21635920092014 @default.
• W2163592009 countsByYear W21635920092015 @default.
• W2163592009 countsByYear W21635920092016 @default.
• W2163592009 countsByYear W21635920092017 @default.
• W2163592009 countsByYear W21635920092018 @default.
• W2163592009 countsByYear W21635920092019 @default.
• W2163592009 countsByYear W21635920092020 @default.
• W2163592009 crossrefType "journal-article" @default.
• W2163592009 hasAuthorship W2163592009A5005386059 @default.
• W2163592009 hasAuthorship W2163592009A5025250742 @default.
• W2163592009 hasAuthorship W2163592009A5028794948 @default.
• W2163592009 hasAuthorship W2163592009A5035398709 @default.
• W2163592009 hasAuthorship W2163592009A5083151857 @default.
• W2163592009 hasBestOaLocation W21635920091 @default.
• W2163592009 hasConcept C104317684 @default.
• W2163592009 hasConcept C107459253 @default.
• W2163592009 hasConcept C119157956 @default.
• W2163592009 hasConcept C145103041 @default.
• W2163592009 hasConcept C148738053 @default.
• W2163592009 hasConcept C150194340 @default.
• W2163592009 hasConcept C150425827 @default.
• W2163592009 hasConcept C165864922 @default.
• W2163592009 hasConcept C207701140 @default.

• next