Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163601036> ?p ?o ?g. }
- W2163601036 endingPage "R122" @default.
- W2163601036 startingPage "R122" @default.
- W2163601036 abstract "Exposure to cadmium is associated with a variety of human diseases. At low concentrations, cadmium activates the transcription of stress-responsive genes, which can prevent or repair the adverse effects caused by this metal. Using Caenorhabditis elegans, 290 genes were identified that are differentially expressed (>1.5-fold) following a 4 or 24 hour exposure to cadmium. Several of these genes are known to be involved in metal detoxification, including mtl-1, mtl-2, cdr-1 and ttm-1, confirming the efficacy of the study. The majority, however, were not previously associated with metal-responsiveness and are novel. Gene Ontology analysis mapped these genes to cellular/ion trafficking, metabolic enzymes and proteolysis categories. RNA interference-mediated inhibition of 50 cadmium-responsive genes resulted in an increased sensitivity to cadmium toxicity, demonstrating that these genes are involved in the resistance to cadmium toxicity. Several functional protein interacting networks were identified by interactome analysis. Within one network, the signaling protein KEL-8 was identified. Kel-8 protects C. elegans from cadmium toxicity in a mek-1 (MAPKK)-dependent manner. Because many C. elegans genes and signal transduction pathways are evolutionarily conserved, these results may contribute to the understanding of the functional roles of various genes in cadmium toxicity in higher organisms." @default.
- W2163601036 created "2016-06-24" @default.
- W2163601036 creator A5008308356 @default.
- W2163601036 creator A5018237157 @default.
- W2163601036 creator A5041531695 @default.
- W2163601036 creator A5052369153 @default.
- W2163601036 creator A5059898753 @default.
- W2163601036 date "2007-01-01" @default.
- W2163601036 modified "2023-10-16" @default.
- W2163601036 title "Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity" @default.
- W2163601036 cites W1490837359 @default.
- W2163601036 cites W1807210160 @default.
- W2163601036 cites W1967950532 @default.
- W2163601036 cites W1971056228 @default.
- W2163601036 cites W1981744204 @default.
- W2163601036 cites W1982955812 @default.
- W2163601036 cites W1989943173 @default.
- W2163601036 cites W1998653602 @default.
- W2163601036 cites W2001259429 @default.
- W2163601036 cites W2002279090 @default.
- W2163601036 cites W2005549285 @default.
- W2163601036 cites W2006117889 @default.
- W2163601036 cites W2007810446 @default.
- W2163601036 cites W2008045273 @default.
- W2163601036 cites W2011424178 @default.
- W2163601036 cites W2012384644 @default.
- W2163601036 cites W2013977400 @default.
- W2163601036 cites W2017575645 @default.
- W2163601036 cites W2022539676 @default.
- W2163601036 cites W2026381199 @default.
- W2163601036 cites W2031107018 @default.
- W2163601036 cites W2036931975 @default.
- W2163601036 cites W2038492783 @default.
- W2163601036 cites W2041801913 @default.
- W2163601036 cites W2048409569 @default.
- W2163601036 cites W2056216226 @default.
- W2163601036 cites W2057621057 @default.
- W2163601036 cites W2057865646 @default.
- W2163601036 cites W2057923423 @default.
- W2163601036 cites W2065260586 @default.
- W2163601036 cites W2067450828 @default.
- W2163601036 cites W2068769123 @default.
- W2163601036 cites W2071846297 @default.
- W2163601036 cites W2077896867 @default.
- W2163601036 cites W2082035181 @default.
- W2163601036 cites W2092444113 @default.
- W2163601036 cites W2095785516 @default.
- W2163601036 cites W2098602095 @default.
- W2163601036 cites W2103130220 @default.
- W2163601036 cites W2104208969 @default.
- W2163601036 cites W2112928083 @default.
- W2163601036 cites W2113019448 @default.
- W2163601036 cites W2117132491 @default.
- W2163601036 cites W2118270653 @default.
- W2163601036 cites W2128491398 @default.
- W2163601036 cites W2130385250 @default.
- W2163601036 cites W2138608045 @default.
- W2163601036 cites W2139366028 @default.
- W2163601036 cites W2139703939 @default.
- W2163601036 cites W2141757016 @default.
- W2163601036 cites W2141877446 @default.
- W2163601036 cites W2150297520 @default.
- W2163601036 cites W2150926065 @default.
- W2163601036 cites W2151489843 @default.
- W2163601036 cites W2158507854 @default.
- W2163601036 cites W2159675211 @default.
- W2163601036 cites W2166146113 @default.
- W2163601036 cites W2407586835 @default.
- W2163601036 cites W2408213457 @default.
- W2163601036 cites W2412259962 @default.
- W2163601036 cites W2419760887 @default.
- W2163601036 cites W4241713541 @default.
- W2163601036 cites W4248957948 @default.
- W2163601036 cites W4297874956 @default.
- W2163601036 doi "https://doi.org/10.1186/gb-2007-8-6-r122" @default.
- W2163601036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2394766" @default.
- W2163601036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17592649" @default.
- W2163601036 hasPublicationYear "2007" @default.
- W2163601036 type Work @default.
- W2163601036 sameAs 2163601036 @default.
- W2163601036 citedByCount "148" @default.
- W2163601036 countsByYear W21636010362012 @default.
- W2163601036 countsByYear W21636010362013 @default.
- W2163601036 countsByYear W21636010362014 @default.
- W2163601036 countsByYear W21636010362015 @default.
- W2163601036 countsByYear W21636010362016 @default.
- W2163601036 countsByYear W21636010362017 @default.
- W2163601036 countsByYear W21636010362018 @default.
- W2163601036 countsByYear W21636010362019 @default.
- W2163601036 countsByYear W21636010362020 @default.
- W2163601036 countsByYear W21636010362021 @default.
- W2163601036 countsByYear W21636010362022 @default.
- W2163601036 countsByYear W21636010362023 @default.
- W2163601036 crossrefType "journal-article" @default.
- W2163601036 hasAuthorship W2163601036A5008308356 @default.
- W2163601036 hasAuthorship W2163601036A5018237157 @default.
- W2163601036 hasAuthorship W2163601036A5041531695 @default.
- W2163601036 hasAuthorship W2163601036A5052369153 @default.