FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163615020> ?p ?o ?g. }

• W2163615020 endingPage "988" @default.
• W2163615020 startingPage "982" @default.
• W2163615020 abstract "Neuroblastoma (NB) is a neuroendocrine cancer that occurs most commonly in infants and young children. The Hippo signaling pathway regulates cell proliferation and apoptosis, and its primary downstream effectors are TAZ and yes‑associated protein 1 (YAP). The effect of TAZ on the metastatic progression of neuroblastoma and the underlying mechanisms involved remain elusive. In the current study, it was determined by western blot analysis that the migratory and invasive properties of SK‑N‑BE(2) human neuroblastoma cells are associated with high expression levels of TAZ. Repressed expression of TAZ in SK‑N‑BE(2) cells was shown to result in a reduction in aggressiveness of the cell line, by Transwell migration and invasion assay. In contrast, overexpression of TAZ in SK‑N‑SH human neuroblastoma cells was shown by Transwell migration and invasion assays, and western blot analysis, to result in epithelial‑mesenchymal transition (EMT) and increased invasiveness. Mechanistically, the overexpression of TAZ was demonstrated to upregulate the expression levels of connective tissue growth factor (CTGF), by western blot analysis and chromatin immunoprecipitation assay, while the knockdown of TAZ downregulated it. Furthermore, TAZ was shown by luciferase assay to induce CTGF expression by modulating the activation of the TGF‑β/Smad3 signaling pathway. In conclusion, the present study is, to the best of our knowledge, the first to demonstrate that the overexpression of TAZ induces EMT, increasing the invasive abilities of neuroblastoma cells. This suggests that TAZ may serve as a potential target in the development of novel therapies for the treatment of neuroblastoma." @default.
• W2163615020 created "2016-06-24" @default.
• W2163615020 creator A5005039268 @default.
• W2163615020 creator A5022234913 @default.
• W2163615020 creator A5030863883 @default.
• W2163615020 creator A5041422238 @default.
• W2163615020 creator A5042899979 @default.
• W2163615020 creator A5080932283 @default.
• W2163615020 creator A5087585028 @default.
• W2163615020 date "2014-10-30" @default.
• W2163615020 modified "2023-10-15" @default.
• W2163615020 title "TAZ promotes epithelial to mesenchymal transition via the upregulation of connective tissue growth factor expression in neuroblastoma cells" @default.
• W2163615020 cites W1978604814 @default.
• W2163615020 cites W1993058424 @default.
• W2163615020 cites W1999536759 @default.
• W2163615020 cites W2025647419 @default.
• W2163615020 cites W2032689441 @default.
• W2163615020 cites W2041401454 @default.
• W2163615020 cites W2049378557 @default.
• W2163615020 cites W2050423426 @default.
• W2163615020 cites W2054013802 @default.
• W2163615020 cites W2073157874 @default.
• W2163615020 cites W2100089498 @default.
• W2163615020 cites W2114906733 @default.
• W2163615020 cites W2118971140 @default.
• W2163615020 cites W2123511906 @default.
• W2163615020 cites W2124259110 @default.
• W2163615020 cites W2127190481 @default.
• W2163615020 cites W2135726634 @default.
• W2163615020 cites W2146337514 @default.
• W2163615020 cites W2154589460 @default.
• W2163615020 cites W2165238621 @default.
• W2163615020 cites W2169110374 @default.
• W2163615020 doi "https://doi.org/10.3892/mmr.2014.2818" @default.
• W2163615020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4262480" @default.
• W2163615020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25354978" @default.
• W2163615020 hasPublicationYear "2014" @default.
• W2163615020 type Work @default.
• W2163615020 sameAs 2163615020 @default.
• W2163615020 citedByCount "38" @default.
• W2163615020 countsByYear W21636150202015 @default.
• W2163615020 countsByYear W21636150202016 @default.
• W2163615020 countsByYear W21636150202017 @default.
• W2163615020 countsByYear W21636150202018 @default.
• W2163615020 countsByYear W21636150202019 @default.
• W2163615020 countsByYear W21636150202020 @default.
• W2163615020 countsByYear W21636150202021 @default.
• W2163615020 countsByYear W21636150202022 @default.
• W2163615020 countsByYear W21636150202023 @default.
• W2163615020 crossrefType "journal-article" @default.
• W2163615020 hasAuthorship W2163615020A5005039268 @default.
• W2163615020 hasAuthorship W2163615020A5022234913 @default.
• W2163615020 hasAuthorship W2163615020A5030863883 @default.
• W2163615020 hasAuthorship W2163615020A5041422238 @default.
• W2163615020 hasAuthorship W2163615020A5042899979 @default.
• W2163615020 hasAuthorship W2163615020A5080932283 @default.
• W2163615020 hasAuthorship W2163615020A5087585028 @default.
• W2163615020 hasBestOaLocation W21636150201 @default.
• W2163615020 hasConcept C104317684 @default.
• W2163615020 hasConcept C127561419 @default.
• W2163615020 hasConcept C1491633281 @default.
• W2163615020 hasConcept C170493617 @default.
• W2163615020 hasConcept C173396325 @default.
• W2163615020 hasConcept C2775960820 @default.
• W2163615020 hasConcept C2776415932 @default.
• W2163615020 hasConcept C2776715637 @default.
• W2163615020 hasConcept C2780631158 @default.
• W2163615020 hasConcept C2781018059 @default.
• W2163615020 hasConcept C29537977 @default.
• W2163615020 hasConcept C502942594 @default.
• W2163615020 hasConcept C54355233 @default.
• W2163615020 hasConcept C55493867 @default.
• W2163615020 hasConcept C62112901 @default.
• W2163615020 hasConcept C62478195 @default.
• W2163615020 hasConcept C76419328 @default.
• W2163615020 hasConcept C81885089 @default.
• W2163615020 hasConcept C86803240 @default.
• W2163615020 hasConcept C95444343 @default.
• W2163615020 hasConceptScore W2163615020C104317684 @default.
• W2163615020 hasConceptScore W2163615020C127561419 @default.
• W2163615020 hasConceptScore W2163615020C1491633281 @default.
• W2163615020 hasConceptScore W2163615020C170493617 @default.
• W2163615020 hasConceptScore W2163615020C173396325 @default.
• W2163615020 hasConceptScore W2163615020C2775960820 @default.
• W2163615020 hasConceptScore W2163615020C2776415932 @default.
• W2163615020 hasConceptScore W2163615020C2776715637 @default.
• W2163615020 hasConceptScore W2163615020C2780631158 @default.
• W2163615020 hasConceptScore W2163615020C2781018059 @default.
• W2163615020 hasConceptScore W2163615020C29537977 @default.
• W2163615020 hasConceptScore W2163615020C502942594 @default.
• W2163615020 hasConceptScore W2163615020C54355233 @default.
• W2163615020 hasConceptScore W2163615020C55493867 @default.
• W2163615020 hasConceptScore W2163615020C62112901 @default.
• W2163615020 hasConceptScore W2163615020C62478195 @default.
• W2163615020 hasConceptScore W2163615020C76419328 @default.
• W2163615020 hasConceptScore W2163615020C81885089 @default.
• W2163615020 hasConceptScore W2163615020C86803240 @default.
• W2163615020 hasConceptScore W2163615020C95444343 @default.

• next