Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163657625> ?p ?o ?g. }
- W2163657625 endingPage "132" @default.
- W2163657625 startingPage "125" @default.
- W2163657625 abstract "Chronic lymphocytic leukemia (CLL) is uniquely characterized by the existence of subsets of cases with quasi-identical, 'stereotyped' B-cell receptors (BCRs). Herein we investigate this stereotypy in 2662 patients with CLL, the largest series yet, using purpose-built bioinformatics methods based on sequence pattern discovery. Besides improving the identification of 'stereotyped' cases, we demonstrate that CLL actually consists of two different categories, based on the BCR repertoire, with important biological and ontogenetic differences. The first ( approximately 30% of cases) shows a very restricted repertoire and is characterized by BCR stereotypy (clustered cases), whereas the second includes cases with heterogeneous BCRs (nonclustered cases). Eleven major CLL clusters were identified with antigen-binding sites defined by just a few critically positioned residues, regardless of the actual immunoglobulin (IG) variable gene used. This situation is closely reminiscent of the receptors expressed by cells participating in innate immune responses. On these grounds, we argue that whereas CLL cases with heterogeneous BCRs likely derive from the conventional B-cell pool, cases with stereotyped BCRs could derive from progenitor cells evolutionarily adapted to particular antigenic challenges, perhaps intermediate between a true innate immune system and the conventional adaptive B-cell immune system, functionally similar to what has been suggested previously for mouse B1 cells." @default.
- W2163657625 created "2016-06-24" @default.
- W2163657625 creator A5002784304 @default.
- W2163657625 creator A5012486639 @default.
- W2163657625 creator A5018345688 @default.
- W2163657625 creator A5018538693 @default.
- W2163657625 creator A5025629990 @default.
- W2163657625 creator A5036447210 @default.
- W2163657625 creator A5040068557 @default.
- W2163657625 creator A5040500242 @default.
- W2163657625 creator A5044130307 @default.
- W2163657625 creator A5045095325 @default.
- W2163657625 creator A5055083609 @default.
- W2163657625 creator A5055869865 @default.
- W2163657625 creator A5056554686 @default.
- W2163657625 creator A5074404064 @default.
- W2163657625 creator A5083128083 @default.
- W2163657625 creator A5090615083 @default.
- W2163657625 date "2009-09-17" @default.
- W2163657625 modified "2023-10-15" @default.
- W2163657625 title "A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence" @default.
- W2163657625 cites W1970584505 @default.
- W2163657625 cites W1973690024 @default.
- W2163657625 cites W1975712548 @default.
- W2163657625 cites W2010425787 @default.
- W2163657625 cites W2023471150 @default.
- W2163657625 cites W2028903194 @default.
- W2163657625 cites W2030693000 @default.
- W2163657625 cites W2033701042 @default.
- W2163657625 cites W2049631297 @default.
- W2163657625 cites W2052259240 @default.
- W2163657625 cites W2061410538 @default.
- W2163657625 cites W2062165674 @default.
- W2163657625 cites W2062581231 @default.
- W2163657625 cites W2068868786 @default.
- W2163657625 cites W2078356972 @default.
- W2163657625 cites W2083445427 @default.
- W2163657625 cites W2091477384 @default.
- W2163657625 cites W2092696877 @default.
- W2163657625 cites W2098166849 @default.
- W2163657625 cites W2099645570 @default.
- W2163657625 cites W2099909147 @default.
- W2163657625 cites W2102098396 @default.
- W2163657625 cites W2105655824 @default.
- W2163657625 cites W2109442096 @default.
- W2163657625 cites W2111609050 @default.
- W2163657625 cites W2113169771 @default.
- W2163657625 cites W2113398700 @default.
- W2163657625 cites W2116324811 @default.
- W2163657625 cites W2123045903 @default.
- W2163657625 cites W2125121305 @default.
- W2163657625 cites W2129375889 @default.
- W2163657625 cites W2132080325 @default.
- W2163657625 cites W2139320786 @default.
- W2163657625 cites W2140384293 @default.
- W2163657625 cites W2142978323 @default.
- W2163657625 cites W2145796979 @default.
- W2163657625 cites W2150013151 @default.
- W2163657625 cites W2155119261 @default.
- W2163657625 cites W2158038705 @default.
- W2163657625 cites W2158714788 @default.
- W2163657625 cites W2166526425 @default.
- W2163657625 cites W4250894669 @default.
- W2163657625 cites W49699810 @default.
- W2163657625 cites W2090639367 @default.
- W2163657625 doi "https://doi.org/10.1038/leu.2009.186" @default.
- W2163657625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19759557" @default.
- W2163657625 hasPublicationYear "2009" @default.
- W2163657625 type Work @default.
- W2163657625 sameAs 2163657625 @default.
- W2163657625 citedByCount "113" @default.
- W2163657625 countsByYear W21636576252012 @default.
- W2163657625 countsByYear W21636576252013 @default.
- W2163657625 countsByYear W21636576252014 @default.
- W2163657625 countsByYear W21636576252015 @default.
- W2163657625 countsByYear W21636576252016 @default.
- W2163657625 countsByYear W21636576252017 @default.
- W2163657625 countsByYear W21636576252018 @default.
- W2163657625 countsByYear W21636576252019 @default.
- W2163657625 countsByYear W21636576252020 @default.
- W2163657625 countsByYear W21636576252021 @default.
- W2163657625 countsByYear W21636576252022 @default.
- W2163657625 countsByYear W21636576252023 @default.
- W2163657625 crossrefType "journal-article" @default.
- W2163657625 hasAuthorship W2163657625A5002784304 @default.
- W2163657625 hasAuthorship W2163657625A5012486639 @default.
- W2163657625 hasAuthorship W2163657625A5018345688 @default.
- W2163657625 hasAuthorship W2163657625A5018538693 @default.
- W2163657625 hasAuthorship W2163657625A5025629990 @default.
- W2163657625 hasAuthorship W2163657625A5036447210 @default.
- W2163657625 hasAuthorship W2163657625A5040068557 @default.
- W2163657625 hasAuthorship W2163657625A5040500242 @default.
- W2163657625 hasAuthorship W2163657625A5044130307 @default.
- W2163657625 hasAuthorship W2163657625A5045095325 @default.
- W2163657625 hasAuthorship W2163657625A5055083609 @default.
- W2163657625 hasAuthorship W2163657625A5055869865 @default.
- W2163657625 hasAuthorship W2163657625A5056554686 @default.
- W2163657625 hasAuthorship W2163657625A5074404064 @default.