FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163663923> ?p ?o ?g. }

• W2163663923 endingPage "7434" @default.
• W2163663923 startingPage "7429" @default.
• W2163663923 abstract "Oxidative DNA damage is generated by reactive oxygen species. The mutagenic base, 8-oxoguanine, formed by this process, is removed from oxidatively damaged DNA by base excision repair. Genes coding for DNA repair enzymes that recognize 8-oxoguanine have been reported in bacteria and yeast. We have identified and characterized mouse and human cDNAs encoding homologs of the 8-oxoguanine DNA glycosylase ( ogg1 ) gene of Saccharomyces cerevisiae. Escherichia coli doubly mutant for mutM and mutY have a mutator phenotype and are deficient in 8-oxoguanine repair. The recombinant mouse gene (mOgg1) suppresses the mutator phenotype of mutY/mutM E. coli . Extracts prepared from mutY/mutM E. coli expressing mOgg1 contain an activity that excises 8-oxoguanine from DNA and a β-lyase activity that nicks DNA 3′ to the lesion. The mouse ogg1 gene product acts efficiently on DNA duplexes in which 7,8-dihydroxy-8-oxo-2′-deoxyguanosine (8-oxodG) is paired with dC, acts weakly on duplexes in which 8-oxodG is paired with dT or dG, and is inactive against duplexes in which 8-oxodG is paired with dA. Mouse and human ogg1 genes contain a helix–hairpin–helix structural motif with conserved residues characteristic of a recently defined family of DNA glycosylases. Ogg1 mRNA is expressed in several mouse tissues; highest levels were detected in testes. Isolation of the mouse ogg1 gene makes it possible to modulate its expression in mice and to explore the involvement of oxidative DNA damage and associated repair processes in aging and cancer." @default.
• W2163663923 created "2016-06-24" @default.
• W2163663923 creator A5033638378 @default.
• W2163663923 creator A5051552099 @default.
• W2163663923 creator A5072938304 @default.
• W2163663923 date "1997-07-08" @default.
• W2163663923 modified "2023-10-18" @default.
• W2163663923 title "Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase" @default.
• W2163663923 cites W1494022099 @default.
• W2163663923 cites W1510358641 @default.
• W2163663923 cites W1518449135 @default.
• W2163663923 cites W1558506222 @default.
• W2163663923 cites W1599053981 @default.
• W2163663923 cites W1953968639 @default.
• W2163663923 cites W1967825316 @default.
• W2163663923 cites W1970582629 @default.
• W2163663923 cites W1977966652 @default.
• W2163663923 cites W1979342693 @default.
• W2163663923 cites W1984290310 @default.
• W2163663923 cites W1986245883 @default.
• W2163663923 cites W1998426722 @default.
• W2163663923 cites W2008427885 @default.
• W2163663923 cites W2011068146 @default.
• W2163663923 cites W2011745892 @default.
• W2163663923 cites W2023518603 @default.
• W2163663923 cites W2023677185 @default.
• W2163663923 cites W2025824008 @default.
• W2163663923 cites W2030327204 @default.
• W2163663923 cites W2033136228 @default.
• W2163663923 cites W2033519208 @default.
• W2163663923 cites W2037320922 @default.
• W2163663923 cites W2041683774 @default.
• W2163663923 cites W2055043387 @default.
• W2163663923 cites W2056433079 @default.
• W2163663923 cites W2065026534 @default.
• W2163663923 cites W2071351849 @default.
• W2163663923 cites W2081145376 @default.
• W2163663923 cites W2093365277 @default.
• W2163663923 cites W2095301528 @default.
• W2163663923 cites W2109870797 @default.
• W2163663923 cites W2113104146 @default.
• W2163663923 cites W2144466703 @default.
• W2163663923 cites W2149922717 @default.
• W2163663923 cites W2164613158 @default.
• W2163663923 cites W2314446635 @default.
• W2163663923 cites W28829384 @default.
• W2163663923 doi "https://doi.org/10.1073/pnas.94.14.7429" @default.
• W2163663923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/23838" @default.
• W2163663923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9207108" @default.
• W2163663923 hasPublicationYear "1997" @default.
• W2163663923 type Work @default.
• W2163663923 sameAs 2163663923 @default.
• W2163663923 citedByCount "457" @default.
• W2163663923 countsByYear W21636639232012 @default.
• W2163663923 countsByYear W21636639232013 @default.
• W2163663923 countsByYear W21636639232014 @default.
• W2163663923 countsByYear W21636639232015 @default.
• W2163663923 countsByYear W21636639232016 @default.
• W2163663923 countsByYear W21636639232017 @default.
• W2163663923 countsByYear W21636639232018 @default.
• W2163663923 countsByYear W21636639232019 @default.
• W2163663923 countsByYear W21636639232020 @default.
• W2163663923 countsByYear W21636639232021 @default.
• W2163663923 countsByYear W21636639232022 @default.
• W2163663923 countsByYear W21636639232023 @default.
• W2163663923 crossrefType "journal-article" @default.
• W2163663923 hasAuthorship W2163663923A5033638378 @default.
• W2163663923 hasAuthorship W2163663923A5051552099 @default.
• W2163663923 hasAuthorship W2163663923A5072938304 @default.
• W2163663923 hasBestOaLocation W21636639231 @default.
• W2163663923 hasConcept C104317684 @default.
• W2163663923 hasConcept C134935766 @default.
• W2163663923 hasConcept C141496672 @default.
• W2163663923 hasConcept C143065580 @default.
• W2163663923 hasConcept C143425029 @default.
• W2163663923 hasConcept C153911025 @default.
• W2163663923 hasConcept C187206112 @default.
• W2163663923 hasConcept C192396546 @default.
• W2163663923 hasConcept C552990157 @default.
• W2163663923 hasConcept C55493867 @default.
• W2163663923 hasConcept C86803240 @default.
• W2163663923 hasConceptScore W2163663923C104317684 @default.
• W2163663923 hasConceptScore W2163663923C134935766 @default.
• W2163663923 hasConceptScore W2163663923C141496672 @default.
• W2163663923 hasConceptScore W2163663923C143065580 @default.
• W2163663923 hasConceptScore W2163663923C143425029 @default.
• W2163663923 hasConceptScore W2163663923C153911025 @default.
• W2163663923 hasConceptScore W2163663923C187206112 @default.
• W2163663923 hasConceptScore W2163663923C192396546 @default.
• W2163663923 hasConceptScore W2163663923C552990157 @default.
• W2163663923 hasConceptScore W2163663923C55493867 @default.
• W2163663923 hasConceptScore W2163663923C86803240 @default.
• W2163663923 hasIssue "14" @default.
• W2163663923 hasLocation W21636639231 @default.
• W2163663923 hasLocation W21636639232 @default.
• W2163663923 hasLocation W21636639233 @default.
• W2163663923 hasLocation W21636639234 @default.
• W2163663923 hasOpenAccess W2163663923 @default.

• next