FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163667029> ?p ?o ?g. }

• W2163667029 endingPage "2803" @default.
• W2163667029 startingPage "2796" @default.
• W2163667029 abstract "Glutamate racemase (MurI) provides d-glutamate, a key building block in the peptidoglycan of the bacterial cell wall. Besides having a crucial role in cell wall biosynthesis, MurI proteins from some bacteria have been shown to act as an inhibitor of DNA gyrase. Mycobacterium tuberculosis and Mycobacterium smegmatis MurI exhibit these dual characteristics. Here, we show that the two activities of M. tuberculosis MurI are unlinked and independent of each other. The racemization function of MurI is not essential for its gyrase-inhibitory property. MurI–DNA gyrase interaction influences gyrase activity but has no effect on the racemization activity of MurI. Overexpression of MurI in vivo provides resistance to the action of ciprofloxacin, suggesting the importance of the interaction in gyrase modulation. We propose that the moonlighting activity of MurI has evolved more recently than its racemase function, to play a transient yet important role in gyrase modulation." @default.
• W2163667029 created "2016-06-24" @default.
• W2163667029 creator A5006030743 @default.
• W2163667029 creator A5019318755 @default.
• W2163667029 creator A5081491547 @default.
• W2163667029 date "2008-09-01" @default.
• W2163667029 modified "2023-10-03" @default.
• W2163667029 title "Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme" @default.
• W2163667029 cites W1564628427 @default.
• W2163667029 cites W1966900722 @default.
• W2163667029 cites W1968406662 @default.
• W2163667029 cites W1969245715 @default.
• W2163667029 cites W1976014101 @default.
• W2163667029 cites W1989961670 @default.
• W2163667029 cites W1998450377 @default.
• W2163667029 cites W2003889863 @default.
• W2163667029 cites W2026169768 @default.
• W2163667029 cites W2033427565 @default.
• W2163667029 cites W2048823623 @default.
• W2163667029 cites W2050748701 @default.
• W2163667029 cites W2058601741 @default.
• W2163667029 cites W2064366331 @default.
• W2163667029 cites W2088190713 @default.
• W2163667029 cites W2090551173 @default.
• W2163667029 cites W2133548147 @default.
• W2163667029 cites W2141216256 @default.
• W2163667029 cites W2417532218 @default.
• W2163667029 cites W323856910 @default.
• W2163667029 cites W4240629327 @default.
• W2163667029 doi "https://doi.org/10.1099/mic.0.2008/020933-0" @default.
• W2163667029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18757813" @default.
• W2163667029 hasPublicationYear "2008" @default.
• W2163667029 type Work @default.
• W2163667029 sameAs 2163667029 @default.
• W2163667029 citedByCount "49" @default.
• W2163667029 countsByYear W21636670292012 @default.
• W2163667029 countsByYear W21636670292013 @default.
• W2163667029 countsByYear W21636670292014 @default.
• W2163667029 countsByYear W21636670292015 @default.
• W2163667029 countsByYear W21636670292016 @default.
• W2163667029 countsByYear W21636670292017 @default.
• W2163667029 countsByYear W21636670292018 @default.
• W2163667029 countsByYear W21636670292019 @default.
• W2163667029 countsByYear W21636670292020 @default.
• W2163667029 countsByYear W21636670292021 @default.
• W2163667029 countsByYear W21636670292022 @default.
• W2163667029 countsByYear W21636670292023 @default.
• W2163667029 crossrefType "journal-article" @default.
• W2163667029 hasAuthorship W2163667029A5006030743 @default.
• W2163667029 hasAuthorship W2163667029A5019318755 @default.
• W2163667029 hasAuthorship W2163667029A5081491547 @default.
• W2163667029 hasBestOaLocation W21636670291 @default.
• W2163667029 hasConcept C104317684 @default.
• W2163667029 hasConcept C142724271 @default.
• W2163667029 hasConcept C167125095 @default.
• W2163667029 hasConcept C181199279 @default.
• W2163667029 hasConcept C185592680 @default.
• W2163667029 hasConcept C2776634448 @default.
• W2163667029 hasConcept C2777204207 @default.
• W2163667029 hasConcept C2777975735 @default.
• W2163667029 hasConcept C2781069245 @default.
• W2163667029 hasConcept C547475151 @default.
• W2163667029 hasConcept C552990157 @default.
• W2163667029 hasConcept C55493867 @default.
• W2163667029 hasConcept C60002323 @default.
• W2163667029 hasConcept C71240020 @default.
• W2163667029 hasConcept C71924100 @default.
• W2163667029 hasConcept C86803240 @default.
• W2163667029 hasConcept C89423630 @default.
• W2163667029 hasConceptScore W2163667029C104317684 @default.
• W2163667029 hasConceptScore W2163667029C142724271 @default.
• W2163667029 hasConceptScore W2163667029C167125095 @default.
• W2163667029 hasConceptScore W2163667029C181199279 @default.
• W2163667029 hasConceptScore W2163667029C185592680 @default.
• W2163667029 hasConceptScore W2163667029C2776634448 @default.
• W2163667029 hasConceptScore W2163667029C2777204207 @default.
• W2163667029 hasConceptScore W2163667029C2777975735 @default.
• W2163667029 hasConceptScore W2163667029C2781069245 @default.
• W2163667029 hasConceptScore W2163667029C547475151 @default.
• W2163667029 hasConceptScore W2163667029C552990157 @default.
• W2163667029 hasConceptScore W2163667029C55493867 @default.
• W2163667029 hasConceptScore W2163667029C60002323 @default.
• W2163667029 hasConceptScore W2163667029C71240020 @default.
• W2163667029 hasConceptScore W2163667029C71924100 @default.
• W2163667029 hasConceptScore W2163667029C86803240 @default.
• W2163667029 hasConceptScore W2163667029C89423630 @default.
• W2163667029 hasIssue "9" @default.
• W2163667029 hasLocation W21636670291 @default.
• W2163667029 hasLocation W21636670292 @default.
• W2163667029 hasOpenAccess W2163667029 @default.
• W2163667029 hasPrimaryLocation W21636670291 @default.
• W2163667029 hasRelatedWork W1997288020 @default.
• W2163667029 hasRelatedWork W2079980984 @default.
• W2163667029 hasRelatedWork W2111844997 @default.
• W2163667029 hasRelatedWork W2163667029 @default.
• W2163667029 hasRelatedWork W2207676110 @default.
• W2163667029 hasRelatedWork W2239518055 @default.
• W2163667029 hasRelatedWork W2756030910 @default.

• next