Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163668223> ?p ?o ?g. }
- W2163668223 endingPage "10478" @default.
- W2163668223 startingPage "10470" @default.
- W2163668223 abstract "The MLL gene is a frequent target for leukemia-associated chromosomal translocations that generate dominant-acting chimeric oncoproteins. These invariably contain the amino-terminal 1,400 residues of MLL fused with one of a variety of over 30 distinct nuclear or cytoplasmic partner proteins. Despite the consistent inclusion of the MLL amino-terminal region in leukemia oncoproteins, little is known regarding its molecular contributions to MLL-dependent oncogenesis. Using high-resolution mutagenesis, we identified three MLL domains that are essential for in vitro myeloid transformation via mechanisms that do not compromise subnuclear localization. These include the CXXC/Basic domain and two novel domains of unknown function. Point mutations in the CXXC domain that eliminate myeloid transformation by an MLL fusion protein also abolished recognition and binding of nonmethylated CpG DNA sites in vitro and transactivation in vivo. Our results define a critical role for the CXXC DNA binding domain in MLL-associated oncogenesis, most likely via epigenetic recognition of CpG DNA sites within the regulatory elements of target genes." @default.
- W2163668223 created "2016-06-24" @default.
- W2163668223 creator A5018484568 @default.
- W2163668223 creator A5029486721 @default.
- W2163668223 creator A5081455027 @default.
- W2163668223 date "2004-12-01" @default.
- W2163668223 modified "2023-10-06" @default.
- W2163668223 title "Binding to Nonmethylated CpG DNA Is Essential for Target Recognition, Transactivation, and Myeloid Transformation by an MLL Oncoprotein" @default.
- W2163668223 cites W1515793897 @default.
- W2163668223 cites W1948730391 @default.
- W2163668223 cites W1976577927 @default.
- W2163668223 cites W1980952706 @default.
- W2163668223 cites W1982315838 @default.
- W2163668223 cites W1982640053 @default.
- W2163668223 cites W1985171686 @default.
- W2163668223 cites W1989403415 @default.
- W2163668223 cites W1995363479 @default.
- W2163668223 cites W1996400683 @default.
- W2163668223 cites W2002797826 @default.
- W2163668223 cites W2008081938 @default.
- W2163668223 cites W2012220765 @default.
- W2163668223 cites W2016237448 @default.
- W2163668223 cites W2020159234 @default.
- W2163668223 cites W2022728666 @default.
- W2163668223 cites W2027556551 @default.
- W2163668223 cites W2032456223 @default.
- W2163668223 cites W2034419609 @default.
- W2163668223 cites W2039795300 @default.
- W2163668223 cites W2040370905 @default.
- W2163668223 cites W2042871287 @default.
- W2163668223 cites W2065422635 @default.
- W2163668223 cites W2066387092 @default.
- W2163668223 cites W2079604568 @default.
- W2163668223 cites W2085092579 @default.
- W2163668223 cites W2090977067 @default.
- W2163668223 cites W2091260442 @default.
- W2163668223 cites W2095184701 @default.
- W2163668223 cites W2095297122 @default.
- W2163668223 cites W2115147255 @default.
- W2163668223 cites W2119749554 @default.
- W2163668223 cites W2121417064 @default.
- W2163668223 cites W2126334907 @default.
- W2163668223 cites W2133494347 @default.
- W2163668223 cites W2138218344 @default.
- W2163668223 cites W2139491272 @default.
- W2163668223 cites W2158773950 @default.
- W2163668223 cites W2326941867 @default.
- W2163668223 cites W2331542870 @default.
- W2163668223 cites W2464299532 @default.
- W2163668223 cites W4246697467 @default.
- W2163668223 cites W4300141132 @default.
- W2163668223 cites W86848570 @default.
- W2163668223 doi "https://doi.org/10.1128/mcb.24.23.10470-10478.2004" @default.
- W2163668223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/529055" @default.
- W2163668223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15542854" @default.
- W2163668223 hasPublicationYear "2004" @default.
- W2163668223 type Work @default.
- W2163668223 sameAs 2163668223 @default.
- W2163668223 citedByCount "154" @default.
- W2163668223 countsByYear W21636682232012 @default.
- W2163668223 countsByYear W21636682232013 @default.
- W2163668223 countsByYear W21636682232014 @default.
- W2163668223 countsByYear W21636682232015 @default.
- W2163668223 countsByYear W21636682232016 @default.
- W2163668223 countsByYear W21636682232017 @default.
- W2163668223 countsByYear W21636682232018 @default.
- W2163668223 countsByYear W21636682232019 @default.
- W2163668223 countsByYear W21636682232020 @default.
- W2163668223 countsByYear W21636682232021 @default.
- W2163668223 countsByYear W21636682232022 @default.
- W2163668223 countsByYear W21636682232023 @default.
- W2163668223 crossrefType "journal-article" @default.
- W2163668223 hasAuthorship W2163668223A5018484568 @default.
- W2163668223 hasAuthorship W2163668223A5029486721 @default.
- W2163668223 hasAuthorship W2163668223A5081455027 @default.
- W2163668223 hasBestOaLocation W21636682231 @default.
- W2163668223 hasConcept C104317684 @default.
- W2163668223 hasConcept C123894998 @default.
- W2163668223 hasConcept C1292079 @default.
- W2163668223 hasConcept C140173407 @default.
- W2163668223 hasConcept C150194340 @default.
- W2163668223 hasConcept C16318435 @default.
- W2163668223 hasConcept C190727270 @default.
- W2163668223 hasConcept C2778729363 @default.
- W2163668223 hasConcept C40767141 @default.
- W2163668223 hasConcept C41091548 @default.
- W2163668223 hasConcept C501734568 @default.
- W2163668223 hasConcept C502942594 @default.
- W2163668223 hasConcept C54355233 @default.
- W2163668223 hasConcept C552990157 @default.
- W2163668223 hasConcept C555283112 @default.
- W2163668223 hasConcept C83640560 @default.
- W2163668223 hasConcept C86339819 @default.
- W2163668223 hasConcept C86803240 @default.
- W2163668223 hasConcept C95444343 @default.
- W2163668223 hasConceptScore W2163668223C104317684 @default.
- W2163668223 hasConceptScore W2163668223C123894998 @default.
- W2163668223 hasConceptScore W2163668223C1292079 @default.