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- W2163669493 abstract "The H2O2inactivation of the “cambialistic” superoxide dismutases fromPropionibacterium shermanii,which is active with either iron or manganese at the active site, has been studied in the native and Val 73 → Trp mutant enzymes. The wild-type iron-containing form of this enzyme is much more resistant to treatment with H2O2with respect to the other metal-specific Fe superoxide dismutase isoenzymes. After incubation with high amounts of H2O2the enzyme maintains more than 40% of the initial activity. The activity of the Val 73 → Trp mutant drastically decreases to less than 5% of the initial activity after incubation with hydrogen peroxide. Amino acid analysis of the H2O2-treated mutant enzyme evidenced the loss of the Trp 73 residue which is shown to play a critical role in the stabilization of the monomer fold of the enzyme. On the other hand, the manganese-containing wild-type and mutant enzymes were completely resistant toward H2O2demonstrating the specific role of iron in the inactivation process." @default.
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- W2163669493 date "1997-09-01" @default.
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- W2163669493 title "Effect of Val 73 → Trp Mutation on the Reaction of “Cambialistic” Superoxide Dismutase fromPropionibacterium shermaniiwith Hydrogen Peroxide" @default.
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- W2163669493 doi "https://doi.org/10.1006/abbi.1997.0235" @default.
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