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• W2163670363 endingPage "697" @default.
• W2163670363 startingPage "687" @default.
• W2163670363 abstract "ABSTRACT PD 404,182 (PD) is a synthetic compound that was found to compromise HIV integrity via interaction with a nonenvelope protein viral structural component (A. M. Chamoun et al., Antimicrob. Agents Chemother. 56:672–681, 2012). The present study evaluates the potential of PD as an anti-HIV microbicide and establishes PD's virucidal activity toward another pathogen, herpes simplex virus (HSV). We show that the anti-HIV-1 50% inhibitory concentration (IC 50 ) of PD, when diluted in seminal plasma, is ∼1 μM, similar to the IC 50 determined in cell culture growth medium, and that PD retains full anti-HIV-1 activity after incubation in cervical fluid at 37°C for at least 24 h. In addition, PD is nontoxic toward vaginal commensal Lactobacillus species (50% cytotoxic concentration [CC 50 ], >300 μM), freshly activated human peripheral blood mononuclear cells (CC 50 , ∼200 μM), and primary CD4 + T cells, macrophages, and dendritic cells (CC 50 , >300 μM). PD also exhibited high stability in pH-adjusted Dulbecco's phosphate-buffered saline with little to no activity loss after 8 weeks at pH 4 and 42°C, indicating suitability for formulation for transportation and storage in developing countries. Finally, for the first time, we show that PD inactivates herpes simplex virus 1 (HSV-1) and HSV-2 at submicromolar concentrations. Due to the prevalence of HSV infection, the ability of PD to inactivate HSV may provide an additional incentive for use as a microbicide. The ability of PD to inactivate both HIV-1 and HSV, combined with its low toxicity and high stability, warrants additional studies for the evaluation of PD's microbicidal candidacy in animals and humans." @default.
• W2163670363 created "2016-06-24" @default.
• W2163670363 creator A5000056939 @default.
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• W2163670363 date "2014-02-01" @default.
• W2163670363 modified "2023-09-30" @default.
• W2163670363 title "Evaluation of PD 404,182 as an Anti-HIV and Anti-Herpes Simplex Virus Microbicide" @default.
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• W2163670363 cites W1976099593 @default.
• W2163670363 cites W1977487387 @default.
• W2163670363 cites W1981740153 @default.
• W2163670363 cites W1985613448 @default.
• W2163670363 cites W1994278598 @default.
• W2163670363 cites W1994566416 @default.
• W2163670363 cites W2005784813 @default.
• W2163670363 cites W2006509278 @default.
• W2163670363 cites W2007941213 @default.
• W2163670363 cites W2010052850 @default.
• W2163670363 cites W2014787681 @default.
• W2163670363 cites W2016720199 @default.
• W2163670363 cites W2020266663 @default.
• W2163670363 cites W2020465880 @default.
• W2163670363 cites W2027548763 @default.
• W2163670363 cites W2028136402 @default.
• W2163670363 cites W2029258256 @default.
• W2163670363 cites W2032367420 @default.
• W2163670363 cites W2034130780 @default.
• W2163670363 cites W2036151418 @default.
• W2163670363 cites W2036479803 @default.
• W2163670363 cites W2048636155 @default.
• W2163670363 cites W2053367335 @default.
• W2163670363 cites W2054233015 @default.
• W2163670363 cites W2054379113 @default.
• W2163670363 cites W2057234669 @default.
• W2163670363 cites W2062804266 @default.
• W2163670363 cites W2064485289 @default.
• W2163670363 cites W2066754037 @default.
• W2163670363 cites W2070443240 @default.
• W2163670363 cites W2075147482 @default.
• W2163670363 cites W2080189655 @default.
• W2163670363 cites W2082465314 @default.
• W2163670363 cites W2089178943 @default.
• W2163670363 cites W2089625895 @default.
• W2163670363 cites W2090385005 @default.
• W2163670363 cites W2096982494 @default.
• W2163670363 cites W2099635197 @default.
• W2163670363 cites W2101072866 @default.
• W2163670363 cites W2107555337 @default.
• W2163670363 cites W2107791948 @default.
• W2163670363 cites W2115149972 @default.
• W2163670363 cites W2116864763 @default.
• W2163670363 cites W2118399443 @default.
• W2163670363 cites W2119902626 @default.
• W2163670363 cites W2121983834 @default.
• W2163670363 cites W2122452548 @default.
• W2163670363 cites W2126255146 @default.
• W2163670363 cites W2127954755 @default.
• W2163670363 cites W2129458123 @default.
• W2163670363 cites W2134950373 @default.
• W2163670363 cites W2135340501 @default.
• W2163670363 cites W2135795769 @default.
• W2163670363 cites W2138170968 @default.
• W2163670363 cites W2143019707 @default.
• W2163670363 cites W2143563155 @default.
• W2163670363 cites W2144198686 @default.
• W2163670363 cites W2144494361 @default.
• W2163670363 cites W2145273953 @default.
• W2163670363 cites W2145718464 @default.
• W2163670363 cites W2146478787 @default.
• W2163670363 cites W2146634980 @default.
• W2163670363 cites W2149817084 @default.
• W2163670363 cites W2150550553 @default.
• W2163670363 cites W2152599479 @default.
• W2163670363 cites W2153747683 @default.
• W2163670363 cites W2154288940 @default.
• W2163670363 cites W2155737863 @default.
• W2163670363 cites W2156543093 @default.
• W2163670363 cites W2159327723 @default.
• W2163670363 cites W2162588806 @default.
• W2163670363 cites W2164665317 @default.
• W2163670363 cites W2165481944 @default.
• W2163670363 cites W2168372190 @default.
• W2163670363 cites W2168527507 @default.
• W2163670363 cites W2169563864 @default.
• W2163670363 cites W2321362907 @default.
• W2163670363 cites W2916542119 @default.
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• W2163670363 doi "https://doi.org/10.1128/aac.02000-13" @default.
• W2163670363 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3910842" @default.
• W2163670363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24217696" @default.
• W2163670363 hasPublicationYear "2014" @default.
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