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- W2163670773 abstract "In this issue of the Journal, Correa et al. (1) provide results from the first reported randomized intervention trial of the effects of anti-Helicobacter pylori treatment and of vitamin supplementation on precancerous lesions of the stomach. The findings are encouraging, with evidence that therapy for H. pylori and supplementation with -carotene or vitamin C may help limit progression and enhance regression of conditions believed to be in the pathway of gastric cancer. Randomized clinical trials provide one of the most scientifically rigorous approaches to evaluate potential inhibitors of cancer. Trials directly evaluating cancer as an outcome require large numbers of persons to be followed, often for many years. In some circumstances, an effective alternative is a smaller, shorter term trial focusing on the carcinogenic process leading to the onset of clinically detectable cancer. Correa et al. followed this strategy in Colombia in an area where gastric cancer rates are high and precancerous lesions of the stomach are fairly common. By studying the effects of interventions on the progression/ regression of these common lesions, information can be obtained on whether intervening may inhibit the early changes leading to cancer. The inherent assumption in such a study is that the carcinogenic process does, in fact, involve a transition from normal epithelium through advancing precancerous lesions. Such a process may exist for a number of cancers, although evidence for most forms of cancer is scanty. For stomach cancer (especially the common intestinal type), however, epidemiologic and pathologic studies have documented that a series of transitions typically are involved (2). In most cases, particularly in high-risk areas, a sequence of events occurs whereby normal gastric mu-" @default.
- W2163670773 created "2016-06-24" @default.
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- W2163670773 date "2000-12-06" @default.
- W2163670773 modified "2023-10-14" @default.
- W2163670773 title "Preventing Cancer by Disrupting Progression of Precancerous Lesions" @default.
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- W2163670773 doi "https://doi.org/10.1093/jnci/92.23.1868" @default.
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