FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163670982> ?p ?o ?g. }

• W2163670982 endingPage "1770" @default.
• W2163670982 startingPage "1758" @default.
• W2163670982 abstract "ABSTRACT An interesting but largely unanswered biological question is how eukaryotic organisms regulate the size of multicellular tissues. During development, a lawn of Dictyostelium cells breaks up into territories, and within the territories the cells aggregate in dendritic streams to form groups of ∼20,000 cells. Using random insertional mutagenesis to search for genes involved in group size regulation, we found that an insertion in the cnrN gene affects group size. Cells lacking CnrN ( cnrN − ) form abnormally small groups, which can be rescued by the expression of exogenous CnrN. Relayed pulses of extracellular cyclic AMP (cAMP) direct cells to aggregate by chemotaxis to form aggregation territories and streams. cnrN − cells overaccumulate cAMP during development and form small territories. Decreasing the cAMP pulse size by treating cnrN − cells with cAMP phosphodiesterase or starving cnrN − cells at a low density rescues the small-territory phenotype. The predicted CnrN sequence has similarity to phosphatase and tensin homolog (PTEN), which in Dictyostelium inhibits cAMP-stimulated phosphatidylinositol 3-kinase signaling pathways. CnrN inhibits cAMP-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation, Akt activation, actin polymerization, and cAMP production. Our results suggest that CnrN is a protein with some similarities to PTEN and that it regulates cAMP signal transduction to regulate territory size." @default.
• W2163670982 created "2016-06-24" @default.
• W2163670982 creator A5015893405 @default.
• W2163670982 creator A5037213535 @default.
• W2163670982 date "2008-10-01" @default.
• W2163670982 modified "2023-10-16" @default.
• W2163670982 title "A Protein with Similarity to PTEN Regulates Aggregation Territory Size by Decreasing Cyclic AMP Pulse Size during <i>Dictyostelium discoideum</i> Development" @default.
• W2163670982 cites W1479953545 @default.
• W2163670982 cites W1963588710 @default.
• W2163670982 cites W1970563574 @default.
• W2163670982 cites W1984621921 @default.
• W2163670982 cites W1986375396 @default.
• W2163670982 cites W1989862378 @default.
• W2163670982 cites W1989964551 @default.
• W2163670982 cites W1993423963 @default.
• W2163670982 cites W1995513139 @default.
• W2163670982 cites W2001165708 @default.
• W2163670982 cites W2001800178 @default.
• W2163670982 cites W2005314771 @default.
• W2163670982 cites W2006126837 @default.
• W2163670982 cites W2006566159 @default.
• W2163670982 cites W2007404245 @default.
• W2163670982 cites W2012095562 @default.
• W2163670982 cites W2013092276 @default.
• W2163670982 cites W2021460799 @default.
• W2163670982 cites W2027699222 @default.
• W2163670982 cites W2033202505 @default.
• W2163670982 cites W2038537091 @default.
• W2163670982 cites W2051541834 @default.
• W2163670982 cites W2053079324 @default.
• W2163670982 cites W2056491244 @default.
• W2163670982 cites W2058475379 @default.
• W2163670982 cites W2062145837 @default.
• W2163670982 cites W2065666472 @default.
• W2163670982 cites W2068881539 @default.
• W2163670982 cites W2071495623 @default.
• W2163670982 cites W2076457965 @default.
• W2163670982 cites W2077173862 @default.
• W2163670982 cites W2083690034 @default.
• W2163670982 cites W2089607882 @default.
• W2163670982 cites W2093675608 @default.
• W2163670982 cites W2101225372 @default.
• W2163670982 cites W2102337843 @default.
• W2163670982 cites W2102617180 @default.
• W2163670982 cites W2108779387 @default.
• W2163670982 cites W2113951321 @default.
• W2163670982 cites W2114459977 @default.
• W2163670982 cites W2117417610 @default.
• W2163670982 cites W2119783639 @default.
• W2163670982 cites W2122039365 @default.
• W2163670982 cites W2123332655 @default.
• W2163670982 cites W2125029383 @default.
• W2163670982 cites W2127383485 @default.
• W2163670982 cites W2128775066 @default.
• W2163670982 cites W2130980659 @default.
• W2163670982 cites W2131456214 @default.
• W2163670982 cites W2131568899 @default.
• W2163670982 cites W2134557279 @default.
• W2163670982 cites W2137814808 @default.
• W2163670982 cites W2138469365 @default.
• W2163670982 cites W2141617119 @default.
• W2163670982 cites W2141983754 @default.
• W2163670982 cites W2146749791 @default.
• W2163670982 cites W2148579405 @default.
• W2163670982 cites W2155047359 @default.
• W2163670982 cites W2156767601 @default.
• W2163670982 cites W2160154454 @default.
• W2163670982 cites W2161834925 @default.
• W2163670982 cites W2163958066 @default.
• W2163670982 cites W2168078204 @default.
• W2163670982 cites W2168711416 @default.
• W2163670982 cites W2171857030 @default.
• W2163670982 cites W2187017352 @default.
• W2163670982 cites W2234616502 @default.
• W2163670982 cites W2789590525 @default.
• W2163670982 doi "https://doi.org/10.1128/ec.00210-08" @default.
• W2163670982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2568059" @default.
• W2163670982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18676953" @default.
• W2163670982 hasPublicationYear "2008" @default.
• W2163670982 type Work @default.
• W2163670982 sameAs 2163670982 @default.
• W2163670982 citedByCount "19" @default.
• W2163670982 countsByYear W21636709822012 @default.
• W2163670982 countsByYear W21636709822013 @default.
• W2163670982 countsByYear W21636709822014 @default.
• W2163670982 countsByYear W21636709822017 @default.
• W2163670982 countsByYear W21636709822018 @default.
• W2163670982 countsByYear W21636709822019 @default.
• W2163670982 countsByYear W21636709822021 @default.
• W2163670982 countsByYear W21636709822023 @default.
• W2163670982 crossrefType "journal-article" @default.
• W2163670982 hasAuthorship W2163670982A5015893405 @default.
• W2163670982 hasAuthorship W2163670982A5037213535 @default.
• W2163670982 hasBestOaLocation W21636709821 @default.
• W2163670982 hasConcept C104317684 @default.
• W2163670982 hasConcept C11960822 @default.
• W2163670982 hasConcept C170493617 @default.
• W2163670982 hasConcept C178666793 @default.

• next