FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163723666> ?p ?o ?g. }

• W2163723666 endingPage "728" @default.
• W2163723666 startingPage "719" @default.
• W2163723666 abstract "The efficacy and the mode of action of pretransplant transfusion with class I major histocompatibility complex (MHC)-disparate splenocytes in establishing a state of peripheral tolerance in adult mice is analyzed. Adult mice injected intravenously with a critical number of approximately 5 x 10(7) allogenic splenocytes accept skin grafts and develop chimerism in the peripheral lymphatic tissues, but not in thymus and bone marrow. In parallel, a split tolerance evolves: the frequency of class I MHC-reactive Lyt-2+ cytotoxic T lymphocyte precursor (CTL-p)- and interleukin 2 (IL-2)-producing T cells falls off in the peripheral lymphoid tissue, but remains unaltered intrathymically. In particular, high affinity CTL-p become clonally undetectable. In vivo generation of tolerant cells is cyclosporin A resistant, but dependent on recipient L3T4+ T cells. Loss of Lyt-2+ CTL-p- and IL-2-producing T cell precursors is not due to active suppression, but is caused by clonal anergy. Donor-derived chimeric cells positively selected 7 d after intravenous transfusion exhibit in vitro the hallmarks of veto cells, i.e., paralyze CTL-p reactive to donor-type class I MHC alloantigens. We conclude that the peripheral (split) tolerance induced in vivo by pretransplant transfusion operates because donor-type cells develop in vivo efficiently into veto cells, which in turn induce a state of clonal anergy within antigen-reactive Lyt-2+ T lymphocytes." @default.
• W2163723666 created "2016-06-24" @default.
• W2163723666 creator A5046981639 @default.
• W2163723666 creator A5068349575 @default.
• W2163723666 date "1990-09-01" @default.
• W2163723666 modified "2023-10-02" @default.
• W2163723666 title "Induction of peripheral tolerance to class I major histocompatibility complex (MHC) alloantigens in adult mice: transfused class I MHC-incompatible splenocytes veto clonal responses of antigen-reactive Lyt-2+ T cells." @default.
• W2163723666 cites W104888853 @default.
• W2163723666 cites W1484731058 @default.
• W2163723666 cites W1527256643 @default.
• W2163723666 cites W1537879192 @default.
• W2163723666 cites W1550383860 @default.
• W2163723666 cites W1573605949 @default.
• W2163723666 cites W1616852357 @default.
• W2163723666 cites W1822281114 @default.
• W2163723666 cites W1860913531 @default.
• W2163723666 cites W1963785498 @default.
• W2163723666 cites W1965645843 @default.
• W2163723666 cites W1980075657 @default.
• W2163723666 cites W1981449752 @default.
• W2163723666 cites W1982068663 @default.
• W2163723666 cites W1982425628 @default.
• W2163723666 cites W1994497303 @default.
• W2163723666 cites W1995313125 @default.
• W2163723666 cites W1999858178 @default.
• W2163723666 cites W2008076949 @default.
• W2163723666 cites W2009817603 @default.
• W2163723666 cites W2010601613 @default.
• W2163723666 cites W2026891958 @default.
• W2163723666 cites W2027306447 @default.
• W2163723666 cites W2028537846 @default.
• W2163723666 cites W2040297427 @default.
• W2163723666 cites W2041878265 @default.
• W2163723666 cites W2048821028 @default.
• W2163723666 cites W2054360138 @default.
• W2163723666 cites W2058367939 @default.
• W2163723666 cites W2067510436 @default.
• W2163723666 cites W2090678351 @default.
• W2163723666 cites W2090953855 @default.
• W2163723666 cites W2108897330 @default.
• W2163723666 cites W2124983348 @default.
• W2163723666 cites W2129650051 @default.
• W2163723666 cites W2139949747 @default.
• W2163723666 cites W2156895470 @default.
• W2163723666 cites W2172383460 @default.
• W2163723666 cites W2180896468 @default.
• W2163723666 cites W2404611980 @default.
• W2163723666 cites W4247338822 @default.
• W2163723666 cites W55114439 @default.
• W2163723666 doi "https://doi.org/10.1084/jem.172.3.719" @default.
• W2163723666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2188552" @default.
• W2163723666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2388033" @default.
• W2163723666 hasPublicationYear "1990" @default.
• W2163723666 type Work @default.
• W2163723666 sameAs 2163723666 @default.
• W2163723666 citedByCount "57" @default.
• W2163723666 countsByYear W21637236662013 @default.
• W2163723666 countsByYear W21637236662016 @default.
• W2163723666 crossrefType "journal-article" @default.
• W2163723666 hasAuthorship W2163723666A5046981639 @default.
• W2163723666 hasAuthorship W2163723666A5068349575 @default.
• W2163723666 hasBestOaLocation W21637236661 @default.
• W2163723666 hasConcept C147483822 @default.
• W2163723666 hasConcept C147969180 @default.
• W2163723666 hasConcept C154317977 @default.
• W2163723666 hasConcept C167672396 @default.
• W2163723666 hasConcept C170627219 @default.
• W2163723666 hasConcept C19317047 @default.
• W2163723666 hasConcept C202751555 @default.
• W2163723666 hasConcept C203014093 @default.
• W2163723666 hasConcept C207936829 @default.
• W2163723666 hasConcept C2776090121 @default.
• W2163723666 hasConcept C2777016536 @default.
• W2163723666 hasConcept C2777702733 @default.
• W2163723666 hasConcept C2777868816 @default.
• W2163723666 hasConcept C54355233 @default.
• W2163723666 hasConcept C86803240 @default.
• W2163723666 hasConcept C8891405 @default.
• W2163723666 hasConceptScore W2163723666C147483822 @default.
• W2163723666 hasConceptScore W2163723666C147969180 @default.
• W2163723666 hasConceptScore W2163723666C154317977 @default.
• W2163723666 hasConceptScore W2163723666C167672396 @default.
• W2163723666 hasConceptScore W2163723666C170627219 @default.
• W2163723666 hasConceptScore W2163723666C19317047 @default.
• W2163723666 hasConceptScore W2163723666C202751555 @default.
• W2163723666 hasConceptScore W2163723666C203014093 @default.
• W2163723666 hasConceptScore W2163723666C207936829 @default.
• W2163723666 hasConceptScore W2163723666C2776090121 @default.
• W2163723666 hasConceptScore W2163723666C2777016536 @default.
• W2163723666 hasConceptScore W2163723666C2777702733 @default.
• W2163723666 hasConceptScore W2163723666C2777868816 @default.
• W2163723666 hasConceptScore W2163723666C54355233 @default.
• W2163723666 hasConceptScore W2163723666C86803240 @default.
• W2163723666 hasConceptScore W2163723666C8891405 @default.
• W2163723666 hasIssue "3" @default.
• W2163723666 hasLocation W21637236661 @default.
• W2163723666 hasLocation W21637236662 @default.
• W2163723666 hasLocation W21637236663 @default.

• next