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• W2163731437 abstract "Decapping is a critical step in the control of gene expression and is regulated by both positive and negative trans factors. Less is known about cis elements that promote decapping. In plants, following microRNA (miRNA)-directed cleavage of an mRNA, a uridine tract can be added onto the exposed 3' end of the resulting 5' fragment, which can promote 5' end decay. We now demonstrate that in mammalian cell extract, addition of five uridine residues to the 3' end of an RNA (U5) promotes decapping relative to an RNA lacking the uridines (U0). Although the decapping stimulation observed in extract required hDcp2, recombinant hDcp2 was unable to support differential decapping of the U0 and U5 RNAs, indicating that the stimulation was likely due to an indirect recruitment of hDcp2 to the RNA. Consistent with the promotion of 5' end decapping by the uridine tract, affinity purification with the U5 RNA revealed the presence of a decapping subcomplex at least consisting of hDcp2, Dcp1a, Edc4, LSm1, and LSm4 that were specifically bound to the U5 RNA but not the U0 RNA. In addition to promoting decapping, the U-tract stabilized the 3' end of the RNA by preventing 3' to 5' exonucleolytic decay to ensure 5' end directional degradation. These data suggest that following post-transcriptional oligo uridylation of an mRNA or mRNA fragment, the U-tract has the capacity to specifically stimulate 5' end decapping to expedite mRNA decay." @default.
• W2163731437 created "2016-06-24" @default.
• W2163731437 creator A5006775091 @default.
• W2163731437 creator A5012497427 @default.
• W2163731437 date "2007-10-17" @default.
• W2163731437 modified "2023-10-17" @default.
• W2163731437 title "3′ Terminal oligo U-tract-mediated stimulation of decapping" @default.
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• W2163731437 doi "https://doi.org/10.1261/rna.765807" @default.
• W2163731437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2080602" @default.
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• W2163731437 hasPublicationYear "2007" @default.
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