FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163749649> ?p ?o ?g. }

• W2163749649 endingPage "945" @default.
• W2163749649 startingPage "937" @default.
• W2163749649 abstract "Transmissible spongiform encephalopathies are closely linked to the accumulation of a pathological isoform of a host-encoded prion protein (PrP(C)), designated PrP(Sc). In an attempt to generate mono- and polyclonal antibodies to ruminant PrP, 32 mice were vaccinated with peptide vaccines which were synthesized according to the amino acid sequence of ovine PrP. By this approach five PrP-reactive polyclonal antisera directed against four different domains of the protein were stimulated. Splenocytes of mice which had developed PrP-reactive antibodies were used for the generation of monoclonal antibodies (MAbs). Obtained PrP-specific MAbs were directed to three different domains of ruminant PrP which differed from the three previously described major MAb binding sites in rodent PrP. MAbs exhibited reactivity with non-denatured ruminant PrP(C) in ELISA and immunoprecipitation and with denatured ovine and bovine PrP(Sc) in immunoblot. Cross-reactivity was observed with PrP(C) of nine other mammalian species and with pathological PrP preferably of ruminants and weakly with that of hamster and mouse. The generated MAbs will be useful tools for the development of diagnostic tests for BSE and scrapie as well as for pathogenesis studies of these diseases." @default.
• W2163749649 created "2016-06-24" @default.
• W2163749649 creator A5051529119 @default.
• W2163749649 creator A5070821691 @default.
• W2163749649 creator A5078928217 @default.
• W2163749649 date "1998-04-01" @default.
• W2163749649 modified "2023-09-29" @default.
• W2163749649 title "Synthetic peptide vaccines yield monoclonal antibodies to cellular and pathological prion proteins of ruminants." @default.
• W2163749649 cites W1557724928 @default.
• W2163749649 cites W1569589585 @default.
• W2163749649 cites W1829344915 @default.
• W2163749649 cites W1973758214 @default.
• W2163749649 cites W1974869964 @default.
• W2163749649 cites W1975922727 @default.
• W2163749649 cites W1980735475 @default.
• W2163749649 cites W2011108781 @default.
• W2163749649 cites W2013679718 @default.
• W2163749649 cites W2021489997 @default.
• W2163749649 cites W2022392367 @default.
• W2163749649 cites W2041867303 @default.
• W2163749649 cites W2082573664 @default.
• W2163749649 cites W2099576534 @default.
• W2163749649 cites W2110420813 @default.
• W2163749649 cites W2159724596 @default.
• W2163749649 cites W2319158554 @default.
• W2163749649 cites W53055727 @default.
• W2163749649 doi "https://doi.org/10.1099/0022-1317-79-4-937" @default.
• W2163749649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9568991" @default.
• W2163749649 hasPublicationYear "1998" @default.
• W2163749649 type Work @default.
• W2163749649 sameAs 2163749649 @default.
• W2163749649 citedByCount "132" @default.
• W2163749649 countsByYear W21637496492012 @default.
• W2163749649 countsByYear W21637496492013 @default.
• W2163749649 countsByYear W21637496492014 @default.
• W2163749649 countsByYear W21637496492015 @default.
• W2163749649 countsByYear W21637496492016 @default.
• W2163749649 countsByYear W21637496492017 @default.
• W2163749649 countsByYear W21637496492018 @default.
• W2163749649 countsByYear W21637496492021 @default.
• W2163749649 countsByYear W21637496492023 @default.
• W2163749649 crossrefType "journal-article" @default.
• W2163749649 hasAuthorship W2163749649A5051529119 @default.
• W2163749649 hasAuthorship W2163749649A5070821691 @default.
• W2163749649 hasAuthorship W2163749649A5078928217 @default.
• W2163749649 hasBestOaLocation W21637496491 @default.
• W2163749649 hasConcept C104317684 @default.
• W2163749649 hasConcept C142724271 @default.
• W2163749649 hasConcept C153911025 @default.
• W2163749649 hasConcept C159047783 @default.
• W2163749649 hasConcept C159654299 @default.
• W2163749649 hasConcept C163864487 @default.
• W2163749649 hasConcept C167625842 @default.
• W2163749649 hasConcept C195616568 @default.
• W2163749649 hasConcept C203014093 @default.
• W2163749649 hasConcept C2776735649 @default.
• W2163749649 hasConcept C2779134260 @default.
• W2163749649 hasConcept C3019804061 @default.
• W2163749649 hasConcept C53345823 @default.
• W2163749649 hasConcept C542903549 @default.
• W2163749649 hasConcept C55493867 @default.
• W2163749649 hasConcept C71924100 @default.
• W2163749649 hasConcept C86803240 @default.
• W2163749649 hasConcept C91523082 @default.
• W2163749649 hasConcept C956191 @default.
• W2163749649 hasConceptScore W2163749649C104317684 @default.
• W2163749649 hasConceptScore W2163749649C142724271 @default.
• W2163749649 hasConceptScore W2163749649C153911025 @default.
• W2163749649 hasConceptScore W2163749649C159047783 @default.
• W2163749649 hasConceptScore W2163749649C159654299 @default.
• W2163749649 hasConceptScore W2163749649C163864487 @default.
• W2163749649 hasConceptScore W2163749649C167625842 @default.
• W2163749649 hasConceptScore W2163749649C195616568 @default.
• W2163749649 hasConceptScore W2163749649C203014093 @default.
• W2163749649 hasConceptScore W2163749649C2776735649 @default.
• W2163749649 hasConceptScore W2163749649C2779134260 @default.
• W2163749649 hasConceptScore W2163749649C3019804061 @default.
• W2163749649 hasConceptScore W2163749649C53345823 @default.
• W2163749649 hasConceptScore W2163749649C542903549 @default.
• W2163749649 hasConceptScore W2163749649C55493867 @default.
• W2163749649 hasConceptScore W2163749649C71924100 @default.
• W2163749649 hasConceptScore W2163749649C86803240 @default.
• W2163749649 hasConceptScore W2163749649C91523082 @default.
• W2163749649 hasConceptScore W2163749649C956191 @default.
• W2163749649 hasIssue "4" @default.
• W2163749649 hasLocation W21637496491 @default.
• W2163749649 hasLocation W21637496492 @default.
• W2163749649 hasOpenAccess W2163749649 @default.
• W2163749649 hasPrimaryLocation W21637496491 @default.
• W2163749649 hasRelatedWork W1855285375 @default.
• W2163749649 hasRelatedWork W1856187979 @default.
• W2163749649 hasRelatedWork W2000032986 @default.
• W2163749649 hasRelatedWork W2017823902 @default.
• W2163749649 hasRelatedWork W2025678534 @default.
• W2163749649 hasRelatedWork W2057918160 @default.
• W2163749649 hasRelatedWork W2063604066 @default.
• W2163749649 hasRelatedWork W2095527878 @default.
• W2163749649 hasRelatedWork W2122808856 @default.

• next