Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163754919> ?p ?o ?g. }
- W2163754919 endingPage "582" @default.
- W2163754919 startingPage "577" @default.
- W2163754919 abstract "Abstract Our study attempts to establish the relationship between telomerase activity and allelic imbalance (AI) on chromosomes 3p and 6 in high‐risk HPV‐containing cervical lesions. These chromosomes were implicated previously in telomerase regulation in HPV containing immortalized cells and cervical cancer cells. Allelotyping and telomerase analysis were carried out on 28 high‐grade cervical lesions (CIN III: n = 20; cervical carcinomas: n = 8), using 23 microsatellite markers on 3p, 6p and 6q. Clear telomerase activity was found in 17 of 28 lesions (61%). Allelic imbalance frequency at 6q14–22 was significantly higher in lesions with detectable telomerase activity, compared to lesions without telomerase activity ( p = 0.02). No association was found between telomerase activity and AI at any of the remaining regions studied on 3p and chromosome 6. In addition, in telomerase positive passages of the HPV 16 immortalized cell line FK16A, shown recently to be responsive to chromosome 6 mediated telomerase repression, AI was found in the overlapping region of 6q14–27. These data suggest that 6q14–22 may contain 1 or more genes involved in telomerase deregulation and immortalization during cervical carcinogenesis. © 2003 Wiley‐Liss, Inc." @default.
- W2163754919 created "2016-06-24" @default.
- W2163754919 creator A5040309636 @default.
- W2163754919 creator A5050227870 @default.
- W2163754919 creator A5050340051 @default.
- W2163754919 creator A5050703968 @default.
- W2163754919 creator A5050978592 @default.
- W2163754919 creator A5056537893 @default.
- W2163754919 creator A5082492592 @default.
- W2163754919 creator A5089637265 @default.
- W2163754919 date "2003-04-01" @default.
- W2163754919 modified "2023-10-15" @default.
- W2163754919 title "Telomerase activity in high-grade cervical lesions is associated with allelic imbalance at 6Q14-22" @default.
- W2163754919 cites W1632349675 @default.
- W2163754919 cites W1858263251 @default.
- W2163754919 cites W190015672 @default.
- W2163754919 cites W1987350137 @default.
- W2163754919 cites W2001731408 @default.
- W2163754919 cites W2009334997 @default.
- W2163754919 cites W2013880323 @default.
- W2163754919 cites W2015692694 @default.
- W2163754919 cites W2029735450 @default.
- W2163754919 cites W2032844640 @default.
- W2163754919 cites W2039934202 @default.
- W2163754919 cites W2040614265 @default.
- W2163754919 cites W2046268297 @default.
- W2163754919 cites W2057096074 @default.
- W2163754919 cites W2058245379 @default.
- W2163754919 cites W2058252263 @default.
- W2163754919 cites W2064415142 @default.
- W2163754919 cites W2065176684 @default.
- W2163754919 cites W2067542122 @default.
- W2163754919 cites W2078220509 @default.
- W2163754919 cites W2094388972 @default.
- W2163754919 cites W2101631220 @default.
- W2163754919 cites W2102936230 @default.
- W2163754919 cites W2109075812 @default.
- W2163754919 cites W2118866113 @default.
- W2163754919 cites W2126708677 @default.
- W2163754919 cites W2138746759 @default.
- W2163754919 cites W2139876308 @default.
- W2163754919 cites W2148272663 @default.
- W2163754919 cites W2152596295 @default.
- W2163754919 cites W2158734487 @default.
- W2163754919 cites W2313110392 @default.
- W2163754919 cites W2329710350 @default.
- W2163754919 cites W2331541144 @default.
- W2163754919 doi "https://doi.org/10.1002/ijc.11145" @default.
- W2163754919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12740903" @default.
- W2163754919 hasPublicationYear "2003" @default.
- W2163754919 type Work @default.
- W2163754919 sameAs 2163754919 @default.
- W2163754919 citedByCount "17" @default.
- W2163754919 countsByYear W21637549192012 @default.
- W2163754919 countsByYear W21637549192014 @default.
- W2163754919 countsByYear W21637549192016 @default.
- W2163754919 crossrefType "journal-article" @default.
- W2163754919 hasAuthorship W2163754919A5040309636 @default.
- W2163754919 hasAuthorship W2163754919A5050227870 @default.
- W2163754919 hasAuthorship W2163754919A5050340051 @default.
- W2163754919 hasAuthorship W2163754919A5050703968 @default.
- W2163754919 hasAuthorship W2163754919A5050978592 @default.
- W2163754919 hasAuthorship W2163754919A5056537893 @default.
- W2163754919 hasAuthorship W2163754919A5082492592 @default.
- W2163754919 hasAuthorship W2163754919A5089637265 @default.
- W2163754919 hasConcept C104317684 @default.
- W2163754919 hasConcept C121608353 @default.
- W2163754919 hasConcept C125593758 @default.
- W2163754919 hasConcept C142724271 @default.
- W2163754919 hasConcept C177336024 @default.
- W2163754919 hasConcept C180754005 @default.
- W2163754919 hasConcept C2778220009 @default.
- W2163754919 hasConcept C30481170 @default.
- W2163754919 hasConcept C502942594 @default.
- W2163754919 hasConcept C54355233 @default.
- W2163754919 hasConcept C555283112 @default.
- W2163754919 hasConcept C61320498 @default.
- W2163754919 hasConcept C71924100 @default.
- W2163754919 hasConcept C86803240 @default.
- W2163754919 hasConcept C94581717 @default.
- W2163754919 hasConceptScore W2163754919C104317684 @default.
- W2163754919 hasConceptScore W2163754919C121608353 @default.
- W2163754919 hasConceptScore W2163754919C125593758 @default.
- W2163754919 hasConceptScore W2163754919C142724271 @default.
- W2163754919 hasConceptScore W2163754919C177336024 @default.
- W2163754919 hasConceptScore W2163754919C180754005 @default.
- W2163754919 hasConceptScore W2163754919C2778220009 @default.
- W2163754919 hasConceptScore W2163754919C30481170 @default.
- W2163754919 hasConceptScore W2163754919C502942594 @default.
- W2163754919 hasConceptScore W2163754919C54355233 @default.
- W2163754919 hasConceptScore W2163754919C555283112 @default.
- W2163754919 hasConceptScore W2163754919C61320498 @default.
- W2163754919 hasConceptScore W2163754919C71924100 @default.
- W2163754919 hasConceptScore W2163754919C86803240 @default.
- W2163754919 hasConceptScore W2163754919C94581717 @default.
- W2163754919 hasIssue "5" @default.
- W2163754919 hasLocation W21637549191 @default.
- W2163754919 hasLocation W21637549192 @default.