Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163773405> ?p ?o ?g. }
- W2163773405 endingPage "85" @default.
- W2163773405 startingPage "5077" @default.
- W2163773405 abstract "Endometrial cancer is associated with increased weight and body size, diabetes, and other conditions that may result from an excess in calories or lack of physical activity. Although a few studies have explored the effect of dietary constituents on the risk of endometrial cancer, the nature of the joint association of these constituents and obesity, energy intake, or energy expenditure with risk is unknown. A population-based case-control study was conducted in Hawaii to examine the association of diet, body size, and physical activity with the risk of endometrial cancer. Subjects included 332 histologically confirmed, primary endometrial cancer cases and 511 controls identified between 1985 and 1993. Cases and controls were residents of Oahu, Hawaii who were between 18 and 84 years of age and were from one of the following ethnic groups: Japanese, Caucasian, Native Hawaiian, Filipino, and Chinese. Cases were identified through the Hawaii Tumor Registry and matched to the controls on age (+/-2.5 years) and ethnicity. In-person interviews, conducted in the subjects' homes, included dietary, reproductive, menstrual, and medical histories and use of exogenous hormones, physical activity, and other lifestyle variables. Weight, girth, and skinfold measurements were taken at the time of the interview. We found a strong dose-response relation of increased body size to the development of endometrial cancer after adjustment for energy intake. The odds ratio (OR) for endometrial cancer among women in the highest quartile of body mass index (BMI; kg/m2) was more than four times that among women in the lowest quartile. Waist, hip, midarm, and wrist girths were positively associated with the estimated risk of endometrial cancer after adjustment for total calories and other nondietary risk factors, although the trends in the ORs were attenuated after adjustment for BMI. Physically active women had a modest reduction in their risk of disease compared with inactive women. Cases consumed a greater percentage of their calories from fat and a lower percentage of their calories from carbohydrates than did controls. Adjustment for BMI reduced the ORs for the highest compared with the lowest quartile of fat calorie intake from 2.0 (95% confidence interval, 1.3-3.2) to 1.6 (95% confidence interval, 1.0-2.6), suggesting that part of the association is explained by obesity. There was a differential effect of fat on endometrial cancer according to BMI. For all components of fat, the associations with endometrial cancer were either minimal or absent among leaner women (i.e., those with BMI below the median), whereas, among more obese women, two-fold differences in risk were observed between women above and below the median of fat intake. Foods that are high in fat and cholesterol, such as red meat, margarine, and eggs, were positively associated with endometrial cancer, whereas cereals, legumes, vegetables, and fruits, particularly those high in lutein, were inversely associated. These findings suggest that women who avoid being overweight and who consume a diet low in plant and animal fats and high in complex carbohydrates are at a reduced risk of endometrial cancer." @default.
- W2163773405 created "2016-06-24" @default.
- W2163773405 creator A5005218449 @default.
- W2163773405 creator A5014707337 @default.
- W2163773405 creator A5016405051 @default.
- W2163773405 creator A5026707321 @default.
- W2163773405 creator A5037434445 @default.
- W2163773405 creator A5054360872 @default.
- W2163773405 creator A5074379257 @default.
- W2163773405 date "1997-11-15" @default.
- W2163773405 modified "2023-10-17" @default.
- W2163773405 title "Diet, body size, physical activity, and the risk of endometrial cancer." @default.
- W2163773405 cites W1507820521 @default.
- W2163773405 cites W1581335795 @default.
- W2163773405 cites W1922007189 @default.
- W2163773405 cites W1939299472 @default.
- W2163773405 cites W1968880139 @default.
- W2163773405 cites W1980215504 @default.
- W2163773405 cites W1980419069 @default.
- W2163773405 cites W1982880247 @default.
- W2163773405 cites W1985881178 @default.
- W2163773405 cites W1986840948 @default.
- W2163773405 cites W1998605599 @default.
- W2163773405 cites W2004812443 @default.
- W2163773405 cites W2008419967 @default.
- W2163773405 cites W2012533199 @default.
- W2163773405 cites W2013506212 @default.
- W2163773405 cites W2018096453 @default.
- W2163773405 cites W2045625338 @default.
- W2163773405 cites W2049397968 @default.
- W2163773405 cites W2074318780 @default.
- W2163773405 cites W2080030644 @default.
- W2163773405 cites W2080310482 @default.
- W2163773405 cites W2097357866 @default.
- W2163773405 cites W2108581685 @default.
- W2163773405 cites W2122624442 @default.
- W2163773405 cites W2124132382 @default.
- W2163773405 cites W2141591527 @default.
- W2163773405 cites W2149354650 @default.
- W2163773405 cites W2161503216 @default.
- W2163773405 cites W2163079946 @default.
- W2163773405 cites W2164938191 @default.
- W2163773405 cites W2182524854 @default.
- W2163773405 cites W2260772665 @default.
- W2163773405 cites W2262867447 @default.
- W2163773405 cites W2517346518 @default.
- W2163773405 cites W2798643531 @default.
- W2163773405 cites W429120262 @default.
- W2163773405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9371506" @default.
- W2163773405 hasPublicationYear "1997" @default.
- W2163773405 type Work @default.
- W2163773405 sameAs 2163773405 @default.
- W2163773405 citedByCount "81" @default.
- W2163773405 countsByYear W21637734052012 @default.
- W2163773405 countsByYear W21637734052014 @default.
- W2163773405 countsByYear W21637734052015 @default.
- W2163773405 countsByYear W21637734052016 @default.
- W2163773405 countsByYear W21637734052017 @default.
- W2163773405 countsByYear W21637734052018 @default.
- W2163773405 countsByYear W21637734052022 @default.
- W2163773405 crossrefType "journal-article" @default.
- W2163773405 hasAuthorship W2163773405A5005218449 @default.
- W2163773405 hasAuthorship W2163773405A5014707337 @default.
- W2163773405 hasAuthorship W2163773405A5016405051 @default.
- W2163773405 hasAuthorship W2163773405A5026707321 @default.
- W2163773405 hasAuthorship W2163773405A5037434445 @default.
- W2163773405 hasAuthorship W2163773405A5054360872 @default.
- W2163773405 hasAuthorship W2163773405A5074379257 @default.
- W2163773405 hasConcept C121608353 @default.
- W2163773405 hasConcept C126322002 @default.
- W2163773405 hasConcept C144024400 @default.
- W2163773405 hasConcept C149923435 @default.
- W2163773405 hasConcept C156957248 @default.
- W2163773405 hasConcept C2777088508 @default.
- W2163773405 hasConcept C2780221984 @default.
- W2163773405 hasConcept C2908647359 @default.
- W2163773405 hasConcept C29456083 @default.
- W2163773405 hasConcept C40438245 @default.
- W2163773405 hasConcept C44249647 @default.
- W2163773405 hasConcept C511355011 @default.
- W2163773405 hasConcept C68443243 @default.
- W2163773405 hasConcept C71924100 @default.
- W2163773405 hasConcept C99454951 @default.
- W2163773405 hasConceptScore W2163773405C121608353 @default.
- W2163773405 hasConceptScore W2163773405C126322002 @default.
- W2163773405 hasConceptScore W2163773405C144024400 @default.
- W2163773405 hasConceptScore W2163773405C149923435 @default.
- W2163773405 hasConceptScore W2163773405C156957248 @default.
- W2163773405 hasConceptScore W2163773405C2777088508 @default.
- W2163773405 hasConceptScore W2163773405C2780221984 @default.
- W2163773405 hasConceptScore W2163773405C2908647359 @default.
- W2163773405 hasConceptScore W2163773405C29456083 @default.
- W2163773405 hasConceptScore W2163773405C40438245 @default.
- W2163773405 hasConceptScore W2163773405C44249647 @default.
- W2163773405 hasConceptScore W2163773405C511355011 @default.
- W2163773405 hasConceptScore W2163773405C68443243 @default.
- W2163773405 hasConceptScore W2163773405C71924100 @default.
- W2163773405 hasConceptScore W2163773405C99454951 @default.