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• W2163781249 abstract "Annals of the New York Academy of SciencesVolume 284, Issue 1 p. 342-350 CELL-DEPENDENT ANTIHERPESVIRAL ACTIVITY OF 5-METHYLARABINOSYLCYTOSINE, AN INTRACELLULAR ARA-T DONOR * J. F. Aswell, J. F. Aswell Department of Microbiology, University of Mississippi Medical Center Jackson, Mississippi 39216Search for more papers by this authorG. A. Gentry, G. A. Gentry Department of Microbiology, University of Mississippi Medical Center Jackson, Mississippi 39216Search for more papers by this author J. F. Aswell, J. F. Aswell Department of Microbiology, University of Mississippi Medical Center Jackson, Mississippi 39216Search for more papers by this authorG. A. Gentry, G. A. Gentry Department of Microbiology, University of Mississippi Medical Center Jackson, Mississippi 39216Search for more papers by this author First published: May 1977 https://doi.org/10.1111/j.1749-6632.1977.tb21969.xCitations: 23 * This work was supported by Grants AI–69 and 5-S01-RR05386 from the National Institutes of Health, and by the Mississippi Division of the American Cancer Society. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Gentry, G. A. & J. F. Aswell. 1975. Inhibition of herpes simplex virus replication by ara-T. Virology 65: 294– 296. 2 Aswell, J. F. & G. A. Gentry. 1975. Selective inhibition of equine herpes virus by 1-β-D-arabinofuranosylthymine (ara-T). Proc. Amer. Soc. Microbiol.: 240. 3 Lieberman, M., A. Pascale, T. W. Schafer & P. E. Came. 1972. Effect of antiviral agents in equine abortion virus-infected hamsters. Antimicrob. Ag. Chemotherapy 1: 143– 147. 4 Hill, J. M., P. A. Morse & G. A. Gentry. 1975. Metabolism of deoxycytidine, thymine, and deoxythymidine in the hamster. Cancer Research 35: 1314– 1319. 5 Morse, P. A. 1963. Pyrimidine metabolism of rat hepatomas in tissue culture. Doctoral Dissertation, University of Wisconsin. 6 Cohen, S. S. 1966. Introduction to the biochemistry of D-arabinosyl nucleosides. Prog. Nucleic Acid Res. Mol. Biol. 5: 1– 88. 7 Camiener, G. W. & C. G. Smith. 1965. Studies of the enzymatic deamination of cytosine arabinoside. I. Enzyme distribution and species specificity. Biochem. Pharmacol. 14: 1405– 1416. 8 Doerr, I. L., J. F. Codington & J. J. Fox. 1967. Nucleosides. XXXV. 1-β-D-Arabinofuranosyl-5-methylcytosine. J. Med. Chem. 10: 247– 248. 9 Renis, H. E., G. E. Underwood & J. H. Hunter. 1967. Antiviral properties of nucleosides structurally related to 1-β-D-arabinofuranosylcytosine. Antimicrob. Ag. Chemotherapy: 675. 10 Buřič, L. & B. Zícha. 1969. The activity of deoxycytidine aminohydrolase in organs of some mammals. Enzym. Biol. Clin. 10: 222– 232. 11 Cooper, G. M. 1973. Phosphorylation of 5-bromodeoxycytidine in cells infected with herpes simplex virus. Proc. Nat. Acad. Sci. U.S.A. 70: 3788– 3792. 12 Shipkowitz, N. L., R. R. Bower, R. N. Appell, C. W. Nordeen, L. R. Overby, W. R. Roderick, J. B. Schleicher & A. M. von Esch. 1973. Suppression of herpes simplex virus infection by phosphonoacetic acid. Appl. Microbiol. 26: 264– 267. 13 Schabel, F. M. Jr. 1968. The antiviral activity of 9-β-D-arabinofuranosyladenine (ara-A). Chemotherapy 13: 321. 14 Hay, J., P. A. J. Perera, J. M. Morrison, G. A. Gentry & J. H. Subak-Sharpe. 1970. Herpes virus-specified proteins. In Strategy of the Viral Genome. G. E. W. Wolstenholme & M. O'Connor, Eds.: 335– 376. Churchill Livingstone, Edinburgh . 15 Jamieson, J. A., G. A. Gentry & J. H. Subak-Sharpe. 1974. Induction of both thymidine and deoxycytidine kinase activity by herpes viruses. J. Gen. Virol. 24: 465– 480. 16 Jamieson, A. T. & J. H. Subak-Sharpe. 1974. Biochemical studies on the herpes simplex virus-specified deoxypyrimidine kinase activity. J. Gen. Virol. 24: 481– 492. 17 Aswell, J. F. & G. A. Gentry. 1976. Arabinosylthymine, a selective inhibitor of herpesvirus replication: Mode of action and basis of selectivity. Proc. Amer. Soc. Microbiol. 228. 18 Dobersen, M. J. & S. Greer. 1976. An assay for pyrimidine deoxyribonucleoside kinase using γ-32P-labeled ATP. Analyt. Biochem. 67: 602– 610. 19 Ho, D. H. W. & E. Frei. 1971. Clinical pharmacology of 1-β-D-arabinofuranosylcytosine. Clin. Pharmacol. Therapy 12: 944– 954. 20 Zícha, B. & L. Buřič. 1969. Deoxycytidine and radiation response: Exceedingly high deoxycytidine aminohydrolase activity in human liver. Science 168: 191– 192. 21 Steuart, C. C. & P. J. Burke. 1971. Cytidine deaminase and the development of resistance to arabinosylcytosine. Nature New Biol. 233: 109– 111. 22 Chabner, B. A., J. C. Drake & D. G. Johns. 1973. Deamination of 5-azacytidine by a human leukemia cell cytidine deaminase. Biochem. Pharmacol. 22: 2763– 2765. 23 Tattersall, M. H. N., K. Ganeshaguru & A. V. Hoffbrand. 1974. Mechanisms of resistance of human acute leukaemia cells to cytosine arabinoside. Brit. J. Haematol. 27: 39– 46. 24 Teng, Y., J. E. Anderson & E. R. Giblett. 1975. Cytidine deaminase: A new genetic polymorphism demonstrated in human granulocytes. Amer. J. Human Genet. 27: 486– 491. 25 Hart, J. S., D. H. Ho, S. L. George, P. Salem, J. A. Gottlieb & E. Frei. 1973. Cytokinetic and molecular pharmacology studies of arabinosylcytosine in metastatic melanoma. Cancer Res. 32: 2711– 2716. Citing Literature Volume284, Issue1Third Conference on Antiviral SubstancesMay 1977Pages 342-350 ReferencesRelatedInformation" @default.
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