Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163810345> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2163810345 endingPage "208" @default.
- W2163810345 startingPage "205" @default.
- W2163810345 abstract "Objective: The aim was to determine the antimalarial drug effectiveness of the combination therapy model of 80% ethanolic extract of sambiloto (EES) and chloroquine on Plasmodium berghei infected mice. Methods: Five groups of P. berghei infected mice were used in this study, divided by three combinations therapy models of EES and chloroquine groups (Model A, B, C), one monotherapy of EES group (Model D) and one untreated group (Model E) as a control. EES and chloroquine were used at a dose of 100 mg/kg mice body weight and 0.15 mg/kg mice body weight, respectively. Only for Model C, chloroquine was used at a dose of 10 mg/kg mice body weight. Three combinations therapy models consisted of Model A: Infected mice treated by EES and chloroquine for 4 days; Model B: treated by EES for 4 days and chloroquine for 1 day at 1st day; Model C: treated by EES for 4 days and chloroquine for 1 day at 4th day. Meanwhile, Model D and E were treated by EES and vehicle each for 4 days, respectively. Blood smear of all mice was prepared with Giemsa stain. Antimalarial activity was determined by the difference between the mean value of parasitemia of control (Model E, taken as 100%) and those of the experimental group (Model A, B, C and D). Results: Three combination therapy models (Model A, B, C) and one monotherapy (Model D) were showed antimalarial activities against parasite with inhibition of parasite growth by 85.61%, 69.31%, 73.64% and 65.14%, respectively. Conclusion: Model A was showed as the most effective combination therapy model on mice infected by malaria. The results indicated that combination therapy model of EES and chloroquine were able to increase the antimalarial effectiveness by 85.61% inhibition of parasite growth and having smaller risk of resistance by using low dose of chloroquine (0.15 mg/kg mice body weight). Keywords: Antimalarial combination therapy, Andrographis paniculata, Chloroquine." @default.
- W2163810345 created "2016-06-24" @default.
- W2163810345 creator A5019193545 @default.
- W2163810345 creator A5026345394 @default.
- W2163810345 creator A5084435286 @default.
- W2163810345 date "2015-03-01" @default.
- W2163810345 modified "2023-09-30" @default.
- W2163810345 title "THE COMBINATION THERAPY MODEL OF ANDROGRAPHIS PANICULATA EXTRACT AND CHLOROQUINE ON PLASMODIUM BERGHEI INFECTED MICE" @default.
- W2163810345 cites W1982604624 @default.
- W2163810345 cites W1997661194 @default.
- W2163810345 cites W2028712134 @default.
- W2163810345 cites W2045880005 @default.
- W2163810345 cites W2051972629 @default.
- W2163810345 cites W2068084252 @default.
- W2163810345 cites W2076589435 @default.
- W2163810345 cites W2106102730 @default.
- W2163810345 cites W2163703246 @default.
- W2163810345 cites W2175472944 @default.
- W2163810345 cites W2340953491 @default.
- W2163810345 cites W2183240073 @default.
- W2163810345 hasPublicationYear "2015" @default.
- W2163810345 type Work @default.
- W2163810345 sameAs 2163810345 @default.
- W2163810345 citedByCount "1" @default.
- W2163810345 countsByYear W21638103452019 @default.
- W2163810345 crossrefType "journal-article" @default.
- W2163810345 hasAuthorship W2163810345A5019193545 @default.
- W2163810345 hasAuthorship W2163810345A5026345394 @default.
- W2163810345 hasAuthorship W2163810345A5084435286 @default.
- W2163810345 hasConcept C126322002 @default.
- W2163810345 hasConcept C142724271 @default.
- W2163810345 hasConcept C147583825 @default.
- W2163810345 hasConcept C203014093 @default.
- W2163810345 hasConcept C204787440 @default.
- W2163810345 hasConcept C2775867548 @default.
- W2163810345 hasConcept C2776999253 @default.
- W2163810345 hasConcept C2777237215 @default.
- W2163810345 hasConcept C2777425658 @default.
- W2163810345 hasConcept C2777970627 @default.
- W2163810345 hasConcept C2778048844 @default.
- W2163810345 hasConcept C2778371730 @default.
- W2163810345 hasConcept C556039675 @default.
- W2163810345 hasConcept C71924100 @default.
- W2163810345 hasConcept C98274493 @default.
- W2163810345 hasConceptScore W2163810345C126322002 @default.
- W2163810345 hasConceptScore W2163810345C142724271 @default.
- W2163810345 hasConceptScore W2163810345C147583825 @default.
- W2163810345 hasConceptScore W2163810345C203014093 @default.
- W2163810345 hasConceptScore W2163810345C204787440 @default.
- W2163810345 hasConceptScore W2163810345C2775867548 @default.
- W2163810345 hasConceptScore W2163810345C2776999253 @default.
- W2163810345 hasConceptScore W2163810345C2777237215 @default.
- W2163810345 hasConceptScore W2163810345C2777425658 @default.
- W2163810345 hasConceptScore W2163810345C2777970627 @default.
- W2163810345 hasConceptScore W2163810345C2778048844 @default.
- W2163810345 hasConceptScore W2163810345C2778371730 @default.
- W2163810345 hasConceptScore W2163810345C556039675 @default.
- W2163810345 hasConceptScore W2163810345C71924100 @default.
- W2163810345 hasConceptScore W2163810345C98274493 @default.
- W2163810345 hasIssue "2" @default.
- W2163810345 hasLocation W21638103451 @default.
- W2163810345 hasOpenAccess W2163810345 @default.
- W2163810345 hasPrimaryLocation W21638103451 @default.
- W2163810345 hasRelatedWork W1218537893 @default.
- W2163810345 hasRelatedWork W1484901207 @default.
- W2163810345 hasRelatedWork W1906215544 @default.
- W2163810345 hasRelatedWork W1977878626 @default.
- W2163810345 hasRelatedWork W1988671698 @default.
- W2163810345 hasRelatedWork W2027626564 @default.
- W2163810345 hasRelatedWork W2078293431 @default.
- W2163810345 hasRelatedWork W2330524596 @default.
- W2163810345 hasRelatedWork W2471070306 @default.
- W2163810345 hasRelatedWork W2735070470 @default.
- W2163810345 hasRelatedWork W2800817856 @default.
- W2163810345 hasRelatedWork W2810668079 @default.
- W2163810345 hasRelatedWork W2898220334 @default.
- W2163810345 hasRelatedWork W3013709715 @default.
- W2163810345 hasRelatedWork W3029558397 @default.
- W2163810345 hasRelatedWork W3095816863 @default.
- W2163810345 hasRelatedWork W3130432400 @default.
- W2163810345 hasRelatedWork W3157800137 @default.
- W2163810345 hasRelatedWork W2182553829 @default.
- W2163810345 hasRelatedWork W2587079048 @default.
- W2163810345 hasVolume "8" @default.
- W2163810345 isParatext "false" @default.
- W2163810345 isRetracted "false" @default.
- W2163810345 magId "2163810345" @default.
- W2163810345 workType "article" @default.