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- W2163811922 abstract "Abstract Fresh human T lymphocytes respond proliferatively to soluble antigens, such as PPD, provided the cell donor has been immunized to those antigens in vivo. This proliferative response requires the addition of antigen-presenting cells bearing autologous HLA-D antigens. This report demonstrates that the proliferative response to PPD activates a collaborative response that aids in the activation of alloreactive cytotoxic T cells (Tc). Furthermore, the proliferative response to soluble PPD alone activates a population of Tc specifically able to destroy autologous target cells passively labeled with PPD. Allogeneic PPD-labeled targets are killed less effectively. This PPD-specific cytotoxicity is not inhibited by soluble PPD, but is competitively inhibited by PPD-labeled autologous cells. Thus, in vitro stimulation with soluble bacterial antigen activates both helper and cytotoxic recognition of antigen-altered self by a mechanism comparable to the recognition of viral or hapten-altered cells." @default.
- W2163811922 created "2016-06-24" @default.
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- W2163811922 date "1982-06-01" @default.
- W2163811922 modified "2023-10-17" @default.
- W2163811922 title "Soluble bacterial antigen induces specific helper and cytotoxic responses by human lymphocytes in vitro." @default.
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- W2163811922 doi "https://doi.org/10.4049/jimmunol.128.6.2734" @default.
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