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• W2163814040 endingPage "4230" @default.
• W2163814040 startingPage "4216" @default.
• W2163814040 abstract "Postsynaptic interactions between dopamine (DA) and glutamate receptors in the nucleus accumbens (NAc) are critical for addiction. To determine the effect of acute and repeated DA receptor stimulation on AMPA receptor (AMPAR) synaptic targeting in medium spiny NAc neurons, we developed a model system consisting of rat NAc neurons cocultured with prefrontal cortex neurons from enhanced green fluorescent protein-expressing mice. Cortical neurons restore excitatory input onto NAc neurons but are distinguishable based on fluorescence. First, we showed that brief D 1 -like agonist exposure increased AMPAR insertion onto extrasynaptic regions of NAc neuronal processes through a mechanism requiring protein kinase A. This facilitated the Ca 2+ /calmodulin dependent protein kinase II (CaMKII)-dependent synaptic incorporation of AMPARs in response to subsequent NMDA receptor (NMDAR) stimulation. Through this mechanism, DA may promote reward- and drug-related plasticity in the NAc. Then, to model effects of repeated in vivo cocaine exposure, we treated cocultures with DA (1 μ m , 30 min) on days 7, 9, and 11 in culture. On day 15, NAc neurons exhibited increased synaptic AMPAR levels. This was associated with CaMKII activation and was blocked by the CaMKII inhibitor KN-93 ( N -[2-[ N -(4-chlorocinnamyl)- N -methylaminomethyl]phenyl]- N -(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate salt). Furthermore, D 1 -like agonist exposure on day 15 no longer increased AMPAR surface expression. This refractoriness was associated with decreased D 1 receptor surface expression. NMDAR surface expression was not altered by acute or repeated DA receptor stimulation. These results suggest that (1) after repeated DA treatment, NAc neurons are more responsive to glutamate inputs but D 1 -like receptor regulation of plasticity is impaired, and (2) NAc/prefrontal cortex cocultures are useful for studying dopamine-induced neuroadaptations." @default.
• W2163814040 created "2016-06-24" @default.
• W2163814040 creator A5016770515 @default.
• W2163814040 creator A5022853815 @default.
• W2163814040 creator A5057350969 @default.
• W2163814040 creator A5040690993 @default.
• W2163814040 date "2008-04-16" @default.
• W2163814040 modified "2023-10-10" @default.
• W2163814040 title "Acute and Chronic Dopamine Receptor Stimulation Modulates AMPA Receptor Trafficking in Nucleus Accumbens Neurons Cocultured with Prefrontal Cortex Neurons" @default.
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