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- W2163852017 abstract "Summary Objectives The decline in the growth hormone/insulin‐like growth factor‐I (GH/IGF‐I) axis during normal aging might be involved in the changes in body composition associated with increasing age. We conducted a study to investigate serum IGF‐I levels across different age categories and a possible association between serum IGF‐I and measurements of body composition in older people. Design A cross‐sectional analysis of community dwelling older people, which participated in a large longitudinal cohort study (Longitudinal Aging Study Amsterdam). Subjects 1319 subjects, 644 men, mean age 75·6 ± 6·6 years and 675 women, mean age 75·4 ± 6·6 years. Main Outcome Measurements IGF‐I, body mass index (BMI), waist, waist‐hip ratio (WHR), fat mass, lean body mass and total bone mineral density. Results IGF‐I levels were significantly lower in the highest age categories. BMI and biceps skinfold measurements were lower in the lowest IGF‐I quartile in men aged ≥75·5 years. In men with a low total physical activity score (<131 min/day), BMI, WHR and skinfolds were significantly lower in the lowest IGF‐I quartile. In women with a high total physical activity score (>174 min/day), WHR was lower in the lowest IGF‐I quartiles. Conclusion In this large cohort of community dwelling older people, we observed lower serum IGF‐I levels in the higher age categories. A low serum IGF‐I was associated with significantly lower measurements of body composition, such as BMI, skinfolds and WHR. These results do not support previous findings that high IGF‐I levels are favourable for a healthy body composition in community dwelling older people." @default.
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- W2163852017 date "2010-07-21" @default.
- W2163852017 modified "2023-10-18" @default.
- W2163852017 title "Serum insulin-like growth factor-I and body composition in community dwelling older people" @default.
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- W2163852017 doi "https://doi.org/10.1111/j.1365-2265.2009.03747.x" @default.
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