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• W2163866622 abstract "In the beginning of the 20th century, management of acute agitation consisted primarily of physical restraint with various devices. The development of pharmacotherapy for acute agitation improved the standard of care by reducing the need for physical restraints. Older treatments involved sedatives, such as barbiturates ( 1 Young G.P. The agitated patient in the emergency department. Emerg Med Clin North Am. 1987; 5: 765-781 PubMed Google Scholar ), but these have been supplanted by safer alternatives. Recent studies of oral atypical antipsychotic medications suggest a definite role for these drugs in patients for whom oral therapy is appropriate ( 2 Currier G.W. Chou J.C.Y. Feifel D et al. Acute treatment of psychotic agitation: a randomized comparison of oral treatment with risperidone and lorazepam versus intramuscular treatment with haloperidol and lorazepam. J Clin Psychiatry. 2004; 65: 386-394 Crossref PubMed Scopus (111) Google Scholar ). However, for those patients who are unwilling or unable to accept oral treatment, parenteral alternatives are critical. Parenteral treatments include droperidol (i.m., i.v.), haloperidol (i.m., i.v.), benzodiazepines (i.m. or i.v.), olanzapine (i.m.), and ziprasidone (i.m.)." @default.
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• W2163866622 date "2004-11-01" @default.
• W2163866622 modified "2023-10-18" @default.
• W2163866622 title "Standard therapies for acute agitation" @default.
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• W2163866622 doi "https://doi.org/10.1016/j.jemermed.2004.09.001" @default.
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