FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163887060> ?p ?o ?g. }

• W2163887060 endingPage "900" @default.
• W2163887060 startingPage "888" @default.
• W2163887060 abstract "Anthracyclines are effective antineoplastic agents. However, the interaction of these drugs with iron (Fe) is an important cause of myocardial toxicity, limiting their therapeutic use (J Lab Clin Med 122:245-251, 1993). To overcome this limitation, it is crucial to understand how anthracyclines interact with the Fe metabolism of myocardial and neoplastic cells. Iron-regulatory proteins (IRPs) play vital roles in regulating cellular Fe metabolism via their mRNA-binding activity. We showed that doxorubicin (DOX) and its analogs interfere with tumor and myocardial cell Fe metabolism by affecting the RNA-binding activity of IRPs. Unexpectedly, experiments with the free radical scavengers, catalase, superoxide dismutase, ebselen, and Mn(III) tetrakis (4-benzoic acid) porphyrin complex, suggested that the effects of DOX on IRP-RNA-binding activity were not due to anthracycline-mediated free radical production. In contrast to previous studies, we showed that the DOX metabolite, doxorubicinol, had no effect on IRP-RNA-binding activity. Rather, the anthracycline-Fe and -copper (Cu) complexes decreased IRP-RNA-binding activity, indicating that formation of anthracycline-metal complexes may affect cellular Fe metabolism. In addition, anthracyclines prevented the response of IRPs to the depletion of intracellular Fe by chelators. This information may be useful in designing novel therapeutic strategies against tumor cells by combining chelators and anthracyclines. Interestingly, the effect of DOX on primary cultures of cardiomyocytes was similar to that observed using neoplastic cells, and particularly notable was the decrease in IRP2-RNA-binding activity. Our results add significant new information regarding the effects of anthracyclines on Fe metabolism that may lead to the design of more effective treatments." @default.
• W2163887060 created "2016-06-24" @default.
• W2163887060 creator A5023259862 @default.
• W2163887060 creator A5061763563 @default.
• W2163887060 date "2002-10-01" @default.
• W2163887060 modified "2023-10-12" @default.
• W2163887060 title "Unexpected Anthracycline-Mediated Alterations in Iron-Regulatory Protein-RNA-Binding Activity: The Iron and Copper Complexes of Anthracyclines Decrease RNA-Binding Activity" @default.
• W2163887060 cites W1487416252 @default.
• W2163887060 cites W1502461041 @default.
• W2163887060 cites W1518840278 @default.
• W2163887060 cites W1524376424 @default.
• W2163887060 cites W1547848353 @default.
• W2163887060 cites W1550693195 @default.
• W2163887060 cites W1594056720 @default.
• W2163887060 cites W1626591090 @default.
• W2163887060 cites W1963578253 @default.
• W2163887060 cites W1972701711 @default.
• W2163887060 cites W1983842085 @default.
• W2163887060 cites W1989781109 @default.
• W2163887060 cites W1991944400 @default.
• W2163887060 cites W2010183849 @default.
• W2163887060 cites W2011230039 @default.
• W2163887060 cites W2017350478 @default.
• W2163887060 cites W2031476399 @default.
• W2163887060 cites W2033711861 @default.
• W2163887060 cites W2043214528 @default.
• W2163887060 cites W2045021009 @default.
• W2163887060 cites W2050304614 @default.
• W2163887060 cites W2063617352 @default.
• W2163887060 cites W2070147796 @default.
• W2163887060 cites W2074700700 @default.
• W2163887060 cites W2085866164 @default.
• W2163887060 cites W2085927442 @default.
• W2163887060 cites W2095241287 @default.
• W2163887060 cites W2099819774 @default.
• W2163887060 cites W2119544587 @default.
• W2163887060 cites W2164932583 @default.
• W2163887060 cites W2185613772 @default.
• W2163887060 cites W2313056002 @default.
• W2163887060 cites W34816746 @default.
• W2163887060 doi "https://doi.org/10.1124/mol.62.4.888" @default.
• W2163887060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12237336" @default.
• W2163887060 hasPublicationYear "2002" @default.
• W2163887060 type Work @default.
• W2163887060 sameAs 2163887060 @default.
• W2163887060 citedByCount "53" @default.
• W2163887060 countsByYear W21638870602012 @default.
• W2163887060 countsByYear W21638870602013 @default.
• W2163887060 countsByYear W21638870602014 @default.
• W2163887060 countsByYear W21638870602015 @default.
• W2163887060 countsByYear W21638870602016 @default.
• W2163887060 countsByYear W21638870602018 @default.
• W2163887060 countsByYear W21638870602020 @default.
• W2163887060 countsByYear W21638870602021 @default.
• W2163887060 countsByYear W21638870602022 @default.
• W2163887060 countsByYear W21638870602023 @default.
• W2163887060 crossrefType "journal-article" @default.
• W2163887060 hasAuthorship W2163887060A5023259862 @default.
• W2163887060 hasAuthorship W2163887060A5061763563 @default.
• W2163887060 hasConcept C104317684 @default.
• W2163887060 hasConcept C107824862 @default.
• W2163887060 hasConcept C121608353 @default.
• W2163887060 hasConcept C185592680 @default.
• W2163887060 hasConcept C2776694085 @default.
• W2163887060 hasConcept C2776802502 @default.
• W2163887060 hasConcept C2777477808 @default.
• W2163887060 hasConcept C2781303535 @default.
• W2163887060 hasConcept C530470458 @default.
• W2163887060 hasConcept C54355233 @default.
• W2163887060 hasConcept C55493867 @default.
• W2163887060 hasConcept C67705224 @default.
• W2163887060 hasConcept C79879829 @default.
• W2163887060 hasConcept C86803240 @default.
• W2163887060 hasConcept C98274493 @default.
• W2163887060 hasConceptScore W2163887060C104317684 @default.
• W2163887060 hasConceptScore W2163887060C107824862 @default.
• W2163887060 hasConceptScore W2163887060C121608353 @default.
• W2163887060 hasConceptScore W2163887060C185592680 @default.
• W2163887060 hasConceptScore W2163887060C2776694085 @default.
• W2163887060 hasConceptScore W2163887060C2776802502 @default.
• W2163887060 hasConceptScore W2163887060C2777477808 @default.
• W2163887060 hasConceptScore W2163887060C2781303535 @default.
• W2163887060 hasConceptScore W2163887060C530470458 @default.
• W2163887060 hasConceptScore W2163887060C54355233 @default.
• W2163887060 hasConceptScore W2163887060C55493867 @default.
• W2163887060 hasConceptScore W2163887060C67705224 @default.
• W2163887060 hasConceptScore W2163887060C79879829 @default.
• W2163887060 hasConceptScore W2163887060C86803240 @default.
• W2163887060 hasConceptScore W2163887060C98274493 @default.
• W2163887060 hasIssue "4" @default.
• W2163887060 hasLocation W21638870601 @default.
• W2163887060 hasLocation W21638870602 @default.
• W2163887060 hasOpenAccess W2163887060 @default.
• W2163887060 hasPrimaryLocation W21638870601 @default.
• W2163887060 hasRelatedWork W1986140815 @default.
• W2163887060 hasRelatedWork W2006185390 @default.
• W2163887060 hasRelatedWork W2053572223 @default.
• W2163887060 hasRelatedWork W2079442927 @default.

• next