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- W2163888154 abstract "acute andchronic gastric mucosal inflammation was scored forseverity, andsystemic humoral immuneresponses toHelicobacter pylori antigens wereassessed by enzyme-linked immunosorbent assays. Onthebasis ofculture, gastric histology, andserologic evaluation, 33 patients wereclassified asH.pylori infected and36wereclassified asuninfected. Thirteen patients hadnegative cultures andstains butwereseropositive andwereanalyzed separately fromtheother twogroups. Specific serumimmunoglobulin G (IgG) subclass responses toH.pylori whole-cell antigens andspecific IgGresponses tothe54-kDa heatshockprotein homolog (Hp54K) andvacuolating cytotoxin weresignificantly greater in infected thaninuninfected patients aswerespecific IgAresponses towhole-cell antigens andcytotoxin (P< 0.001). AmongtheH.pylori-infected persons, serumIgGresponses toHp54Kandtothevacuolating cytotoxin werecorrelated withacutemucosal inflammatory scores. Incontrast, serumIgAresponses towhole-cell sonicate andtovacuolating cytotoxin wereinversely related tochronic inflammatory scores. Bymultivariant regression analysis, onlyspecific serumIgGresponses toHp54Kcorrelated withseverity ofinflammation (both acute andchronic; P < 0.001); these responses maybemarkers ofinflammation orthese antibodies could play adirect roleinthepathogenesis ofH.pylon-induced inflammation. Helicobacter pylon infection isassociated withchronic gastritis andgastroduodenal ulceration andwithadenocarcinoma ofthedistal stomach (1,15,25),butthedeterminants for particular outcomes ofinfection havenotbeencharacterized. Sipponen (28) hassuggested that gender, nonsecretor status, andantral gastritis areindependent hostrisk factors forpeptic ulcer; however, H.pylonvirulence factors alsocouldbe important (2). Soluble cellular antigens suchasurease and heatshockprotein (10,11), avacuolating cytotoxin (4,20), and, morerecently, a128-kDa protein (CagA) associated with cytotoxin production (32)havebeensuggested aspossible inducers ofaninflammatory reaction inthegastric mucosa(21, 22)andcould explain howbacteria living inthemucuslayer canproduce histologic lesions inthefull thickness ofthe mucosa(2, 22). Inaddition, ithasbeensuggested that intensity andspecificity ofthemucosal immuneresponse maycorrelate withthelevel oftissue inflammation (19). Inthis study, we examined apossible relationship between thetypeandseverity ofgastric inflammation andthesystemic humoral immune response toparticular H.pylon antigens. MATERIALSAND METHODS Patients studied. Eighty-two patients presenting tothe Gastroenterology Service oftheDenverDepartment ofVeteransAffairs Medical Center(n= 65)andUniversity of Colorado Hospitals (n= 17)between January andDecember 1987underwent endoscopy fordiagnosis ofuppergastrointes" @default.
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- W2163888154 date "1994-01-01" @default.
- W2163888154 modified "2023-10-18" @default.
- W2163888154 title "Correlation between Serological andMucosal Inflammatory Responses toHelicobacter pylori" @default.
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