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• W216388905 abstract "UBF is a DNA binding protein which interacts with both the promoter and the enhancer of various vertebrate ribosomal RNA genes and functions as a transcription initiation factor for RNA polymerase I (pol I). We have purified murine UBF to apparent molecular homogeneity and demonstrate that its transactivating potential, but not its DNA binding activity, is modulated in response to cell growth. In vivo labelling experiments demonstrate that UBF is a phosphoprotein and that the phosphorylation state is different in growing and quiescent cells. We show that UBF is phosphorylated in vitro by a cellular protein kinase which by several criteria closely resembles casein kinase II (CKII). A major modification involves serine phosphoesterifications in the carboxy terminal hyperacidic tail of UBF. Deletions of this C-terminal domain severely decreases the UBF directed activation of transcription. The data suggest that phosphorylation of UBF by CKII may play an important role in growth dependent control of rRNA synthesis." @default.
• W216388905 created "2016-06-24" @default.
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• W216388905 date "1992-06-01" @default.
• W216388905 modified "2023-09-27" @default.
• W216388905 title "The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C-terminal hyperacidic tail which is essential for transactivation." @default.
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• W216388905 doi "https://doi.org/10.1002/j.1460-2075.1992.tb05280.x" @default.
• W216388905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/556688" @default.
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