Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163988218> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2163988218 endingPage "S119" @default.
- W2163988218 startingPage "S117" @default.
- W2163988218 abstract "Throughout its many years as a powerful smooth muscle stimulant of unknown chemical structure, slow-reacting substance of anaphylaxis (SRS-A) remained an intriguing entity, possibly implicated as a mediator of hypersensitivity reactions, in particular those concerned with allergic asthma. Elucidation of the chemical structure of SRS-A, and the realization that it was not a single substance but rather a mixture of interrelated leukotrienes (LTs), necessitated reappraisal of earlier data about the effects of SRS-A in pulmonary tissue. Furthermore, as the LT family grew larger, interest turned also to other tissues and organ systems, with the ultimate goal to disclose specific targets for the various LTs. It is now generally accepted that the LTs collectively provoke contraction of vascular and nonvascular smooth muscle, enhanced vascular permeability, and accumulation and activation of leukocytes. The LTs often operate with a potency that far exceeds that of traditional autacoids, and they have obvious key targets of action within the pulmonary and cardiovascular systems. It has been conclusively documented that LTs are important mediators in bronchial asthma, and data are accumulating that they are involved in a number of other disease states, such as rheumatoid arthritis, inflammatory bowel disease, glomerulonephritis, and cardiac disorders. This article summarizes the microvascular actions of LTs formed via the 5-lipoxygenase pathway, and the interplay of these LTs and some other eicosanoids and histamine in the process of inflammation." @default.
- W2163988218 created "2016-06-24" @default.
- W2163988218 creator A5059101867 @default.
- W2163988218 creator A5067117159 @default.
- W2163988218 creator A5089470516 @default.
- W2163988218 date "2000-02-01" @default.
- W2163988218 modified "2023-09-25" @default.
- W2163988218 title "Interactions between Leukotrienes and Other Inflammatory Mediators/Modulators in the Microvasculature" @default.
- W2163988218 cites W1541709451 @default.
- W2163988218 cites W1970312718 @default.
- W2163988218 cites W1972439638 @default.
- W2163988218 cites W1980136043 @default.
- W2163988218 cites W1980832959 @default.
- W2163988218 cites W1985708265 @default.
- W2163988218 cites W1992134189 @default.
- W2163988218 cites W1997165412 @default.
- W2163988218 cites W1998377876 @default.
- W2163988218 cites W1999399975 @default.
- W2163988218 cites W2000983477 @default.
- W2163988218 cites W2004554331 @default.
- W2163988218 cites W2011577549 @default.
- W2163988218 cites W2012978481 @default.
- W2163988218 cites W2023435913 @default.
- W2163988218 cites W2050793616 @default.
- W2163988218 cites W2055337340 @default.
- W2163988218 cites W2059429399 @default.
- W2163988218 cites W2072835354 @default.
- W2163988218 cites W2073378854 @default.
- W2163988218 cites W2075453967 @default.
- W2163988218 cites W2075905527 @default.
- W2163988218 cites W2077671101 @default.
- W2163988218 cites W2089899297 @default.
- W2163988218 cites W2120336762 @default.
- W2163988218 cites W2135611603 @default.
- W2163988218 cites W2151277699 @default.
- W2163988218 cites W2155302126 @default.
- W2163988218 cites W2259392365 @default.
- W2163988218 cites W2421597719 @default.
- W2163988218 cites W2005703921 @default.
- W2163988218 doi "https://doi.org/10.1164/ajrccm.161.supplement_1.ltta-23" @default.
- W2163988218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10673239" @default.
- W2163988218 hasPublicationYear "2000" @default.
- W2163988218 type Work @default.
- W2163988218 sameAs 2163988218 @default.
- W2163988218 citedByCount "19" @default.
- W2163988218 countsByYear W21639882182012 @default.
- W2163988218 countsByYear W21639882182021 @default.
- W2163988218 countsByYear W21639882182022 @default.
- W2163988218 crossrefType "journal-article" @default.
- W2163988218 hasAuthorship W2163988218A5059101867 @default.
- W2163988218 hasAuthorship W2163988218A5067117159 @default.
- W2163988218 hasAuthorship W2163988218A5089470516 @default.
- W2163988218 hasConcept C177713679 @default.
- W2163988218 hasConcept C203014093 @default.
- W2163988218 hasConcept C2776042228 @default.
- W2163988218 hasConcept C2776452501 @default.
- W2163988218 hasConcept C2776914184 @default.
- W2163988218 hasConcept C3019752601 @default.
- W2163988218 hasConcept C71924100 @default.
- W2163988218 hasConceptScore W2163988218C177713679 @default.
- W2163988218 hasConceptScore W2163988218C203014093 @default.
- W2163988218 hasConceptScore W2163988218C2776042228 @default.
- W2163988218 hasConceptScore W2163988218C2776452501 @default.
- W2163988218 hasConceptScore W2163988218C2776914184 @default.
- W2163988218 hasConceptScore W2163988218C3019752601 @default.
- W2163988218 hasConceptScore W2163988218C71924100 @default.
- W2163988218 hasIssue "supplement_1" @default.
- W2163988218 hasLocation W21639882181 @default.
- W2163988218 hasLocation W21639882182 @default.
- W2163988218 hasOpenAccess W2163988218 @default.
- W2163988218 hasPrimaryLocation W21639882181 @default.
- W2163988218 hasRelatedWork W1567876945 @default.
- W2163988218 hasRelatedWork W1571778651 @default.
- W2163988218 hasRelatedWork W1924649133 @default.
- W2163988218 hasRelatedWork W2046986971 @default.
- W2163988218 hasRelatedWork W2051809544 @default.
- W2163988218 hasRelatedWork W2316013418 @default.
- W2163988218 hasRelatedWork W2562364476 @default.
- W2163988218 hasRelatedWork W2767759144 @default.
- W2163988218 hasRelatedWork W2903223704 @default.
- W2163988218 hasRelatedWork W2945783588 @default.
- W2163988218 hasVolume "161" @default.
- W2163988218 isParatext "false" @default.
- W2163988218 isRetracted "false" @default.
- W2163988218 magId "2163988218" @default.
- W2163988218 workType "article" @default.