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- W2163993698 abstract "Acute fatty liver of pregnancy (AFLP) is a serious maternal illness occurring in the third trimester of pregnancy with significant perinatal and maternal mortality. Till recently, it has been considered a mysterious illness. In this editorial, we review the recent advances in understanding the pathogenesis of AFLP and discuss the studies documenting a fetal-maternal interaction with a causative association between carrying a fetus with a defect in mitochondrial fatty acid oxidation and development of AFLP. Further, we discuss the impact of these recent advances on the offspring born to women who develop AFLP, such that screening for a genetic defect can be life saving to the newborn and would allow genetic counseling in subsequent pregnancies. The molecular basis and underlying mechanism for this unique fetal-maternal interaction causing maternal liver disease is discussed." @default.
- W2163993698 created "2016-06-24" @default.
- W2163993698 creator A5046089256 @default.
- W2163993698 date "2006-01-01" @default.
- W2163993698 modified "2023-10-18" @default.
- W2163993698 title "Acute fatty liver of pregnancy: An update on pathogenesis and clinical implications" @default.
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- W2163993698 doi "https://doi.org/10.3748/wjg.v12.i46.7397" @default.
- W2163993698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4087582" @default.
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