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• W2164010203 abstract "Podoviridae are double-stranded DNA bacteriophages that use short, non-contractile tails to adsorb to the host cell surface. Within the tail apparatus of P22-like phages, a dedicated fiber known as the tail needle likely functions as a cell envelope-penetrating device to promote ejection of viral DNA inside the host. In Sf6, a P22-like phage that infects Shigella flexneri, the tail needle presents a C-terminal globular knob. This knob, absent in phage P22 but shared in other members of the P22-like genus, represents the outermost exposed tip of the virion that contacts the host cell surface. Here, we report a crystal structure of the Sf6 tail needle knob determined at 1.0 Å resolution. The structure reveals a trimeric globular domain of the TNF fold structurally superimposable with that of the tail-less phage PRD1 spike protein P5 and the adenovirus knob, domains that in both viruses function in receptor binding. However, P22-like phages are not known to utilize a protein receptor and are thought to directly penetrate the host surface. At 1.0 Å resolution, we identified three equivalents of l-glutamic acid (l-Glu) bound to each subunit interface. Although intimately bound to the protein, l-Glu does not increase the structural stability of the trimer nor it affects its ability to self-trimerize in vitro. In analogy to P22 gp26, we suggest the tail needle of phage Sf6 is ejected through the bacterial cell envelope during infection and its C-terminal knob is threaded through peptidoglycan pores formed by glycan strands." @default.
• W2164010203 created "2016-06-24" @default.
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• W2164010203 date "2011-09-01" @default.
• W2164010203 modified "2023-10-13" @default.
• W2164010203 title "Atomic Structure of Bacteriophage Sf6 Tail Needle Knob" @default.
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• W2164010203 doi "https://doi.org/10.1074/jbc.m111.260877" @default.
• W2164010203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3162447" @default.
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• W2164010203 hasPublicationYear "2011" @default.
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