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- W2164029144 endingPage "4752" @default.
- W2164029144 startingPage "4745" @default.
- W2164029144 abstract "Abstract TCR usage has been studied in a panel of Th cell clones specific for the same peptide epitope (P N S Q D R G R P R R S D), derived from the human papillomavirus type 1 (HPV1) E4 protein, and restricted through HLA-DQ8. After identifying the V, D, and J genes used by the TCRs and sequencing across the V(D)J junctions, five different α-chain sequences and five different β-chain sequences, comprising six independent clones, were identified. A structural model of our E4 peptide/HLA-DQ8 complex predicted that the guanidinyl side chain on the arginine residue at position 6 of the peptide could exist in different orientations. An intramolecular interaction between this arginine and the glutamine residue at position four appeared to control this orientation. Interacting HPV1 E4-specific TCRs would therefore have to recognize the complex in different conformations, and molecular modeling of the TCRs suggested that this could be achieved by changing the dimensions of the central pocket formed where the CDR3 loops of the TCR α- and β-chains converge. It is known that interactions between bound peptide and amino acid residues lining the peptide-binding cleft of HLA molecules are important for determining the conformation and orientation of the peptide/MHC complex. The suggestion here that intramolecular interactions between amino acids of close proximity on the bound peptide are also important adds a further level of complexity to the mechanism by which TCRs interact with Ag." @default.
- W2164029144 created "2016-06-24" @default.
- W2164029144 creator A5001394874 @default.
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- W2164029144 creator A5079190655 @default.
- W2164029144 date "1998-11-01" @default.
- W2164029144 modified "2023-10-14" @default.
- W2164029144 title "Structural Aspects of the Interaction Between Heterogeneic Human Papillomavirus Type 1 E4-Specific T Cell Receptors and the Same Peptide/HLA-DQ8 Complex" @default.
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- W2164029144 doi "https://doi.org/10.4049/jimmunol.161.9.4745" @default.
- W2164029144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9794405" @default.
- W2164029144 hasPublicationYear "1998" @default.
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