FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164105087> ?p ?o ?g. }

• W2164105087 endingPage "22" @default.
• W2164105087 startingPage "517" @default.
• W2164105087 abstract "Indole-3-carbinol (I3C) is a component of the human diet, occurring as a conjugate in certain cruciferous vegetables. I3C protects against carcinogenesis in a variety of animal models by modifying carcinogen metabolism. In mice, I3C decreases lung tumor formation by the tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by enhancing its hepatic clearance (M. A. Morse et al., Cancer Res., 50: 2613-2617, 1990). In this study, our goal was to determine whether I3C would have similar effects on NNK metabolism in smokers as it did in mice. Thirteen women took 400 mg of I3C on 5 consecutive days and maintained constant smoking habits during this period. Their urine was analyzed before and after the I3C treatment period for two metabolites of NNK: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronide (NNAL-Gluc). I3C treatment resulted in decreased levels of urinary NNAL, NNAL-Gluc, and NNAL plus NNAL-Gluc, and increased NNAL-Gluc:NNAL ratio in 10 of the 13 women. The mean decreases in NNAL (-0.27 +/- 0.09 pmol/mg creatinine, -23.4%) and NNAL plus NNAL-Gluc (-0.43 +/- 0.16 pmol/mg creatinine, -10.9%) were statistically significant as was the increase in NNAL-Gluc:NNAL ratio (1.1 +/- 0.5, 39.9%). These changes in urinary metabolites of NNK were consistent with those seen in mice treated with I3C and NNK; they suggest that I3C increased hepatic metabolism of NNK in our smokers. This is the first study to examine the effects of I3C on metabolism of an exogenous carcinogen in humans." @default.
• W2164105087 created "2016-06-24" @default.
• W2164105087 creator A5033402104 @default.
• W2164105087 creator A5039328210 @default.
• W2164105087 creator A5047330944 @default.
• W2164105087 creator A5048791515 @default.
• W2164105087 creator A5058506247 @default.
• W2164105087 creator A5059851724 @default.
• W2164105087 date "1997-07-01" @default.
• W2164105087 modified "2023-10-03" @default.
• W2164105087 title "Effects of indole-3-carbinol on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers." @default.
• W2164105087 cites W1522003696 @default.
• W2164105087 cites W1528238782 @default.
• W2164105087 cites W1545187120 @default.
• W2164105087 cites W1563605508 @default.
• W2164105087 cites W166448751 @default.
• W2164105087 cites W1833006660 @default.
• W2164105087 cites W1848600034 @default.
• W2164105087 cites W1897120345 @default.
• W2164105087 cites W1945616898 @default.
• W2164105087 cites W1959216631 @default.
• W2164105087 cites W1964797585 @default.
• W2164105087 cites W1971359017 @default.
• W2164105087 cites W1981126660 @default.
• W2164105087 cites W1982244915 @default.
• W2164105087 cites W1995534947 @default.
• W2164105087 cites W2023154795 @default.
• W2164105087 cites W2028718177 @default.
• W2164105087 cites W2039830969 @default.
• W2164105087 cites W2041720984 @default.
• W2164105087 cites W2054271333 @default.
• W2164105087 cites W2059861550 @default.
• W2164105087 cites W2060740129 @default.
• W2164105087 cites W2061805255 @default.
• W2164105087 cites W2063344487 @default.
• W2164105087 cites W2088343256 @default.
• W2164105087 cites W2092518624 @default.
• W2164105087 cites W2098872781 @default.
• W2164105087 cites W2102516237 @default.
• W2164105087 cites W2106610537 @default.
• W2164105087 cites W2118397996 @default.
• W2164105087 cites W2120143163 @default.
• W2164105087 cites W2136798908 @default.
• W2164105087 cites W2138076916 @default.
• W2164105087 cites W2140319323 @default.
• W2164105087 cites W2151813520 @default.
• W2164105087 cites W2157252210 @default.
• W2164105087 cites W2158458688 @default.
• W2164105087 cites W2165030404 @default.
• W2164105087 cites W2169371262 @default.
• W2164105087 cites W2170062209 @default.
• W2164105087 cites W2291601448 @default.
• W2164105087 cites W2338251139 @default.
• W2164105087 cites W2340518598 @default.
• W2164105087 cites W2344672950 @default.
• W2164105087 cites W2409083299 @default.
• W2164105087 cites W32456633 @default.
• W2164105087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9232339" @default.
• W2164105087 hasPublicationYear "1997" @default.
• W2164105087 type Work @default.
• W2164105087 sameAs 2164105087 @default.
• W2164105087 citedByCount "6" @default.
• W2164105087 countsByYear W21641050872014 @default.
• W2164105087 countsByYear W21641050872020 @default.
• W2164105087 crossrefType "journal-article" @default.
• W2164105087 hasAuthorship W2164105087A5033402104 @default.
• W2164105087 hasAuthorship W2164105087A5039328210 @default.
• W2164105087 hasAuthorship W2164105087A5047330944 @default.
• W2164105087 hasAuthorship W2164105087A5048791515 @default.
• W2164105087 hasAuthorship W2164105087A5058506247 @default.
• W2164105087 hasAuthorship W2164105087A5059851724 @default.
• W2164105087 hasConcept C114246631 @default.
• W2164105087 hasConcept C121608353 @default.
• W2164105087 hasConcept C126322002 @default.
• W2164105087 hasConcept C134018914 @default.
• W2164105087 hasConcept C185592680 @default.
• W2164105087 hasConcept C2777395278 @default.
• W2164105087 hasConcept C2779487296 @default.
• W2164105087 hasConcept C2780026642 @default.
• W2164105087 hasConcept C2780306776 @default.
• W2164105087 hasConcept C55493867 @default.
• W2164105087 hasConcept C62231903 @default.
• W2164105087 hasConcept C71924100 @default.
• W2164105087 hasConcept C77411442 @default.
• W2164105087 hasConceptScore W2164105087C114246631 @default.
• W2164105087 hasConceptScore W2164105087C121608353 @default.
• W2164105087 hasConceptScore W2164105087C126322002 @default.
• W2164105087 hasConceptScore W2164105087C134018914 @default.
• W2164105087 hasConceptScore W2164105087C185592680 @default.
• W2164105087 hasConceptScore W2164105087C2777395278 @default.
• W2164105087 hasConceptScore W2164105087C2779487296 @default.
• W2164105087 hasConceptScore W2164105087C2780026642 @default.
• W2164105087 hasConceptScore W2164105087C2780306776 @default.
• W2164105087 hasConceptScore W2164105087C55493867 @default.
• W2164105087 hasConceptScore W2164105087C62231903 @default.
• W2164105087 hasConceptScore W2164105087C71924100 @default.
• W2164105087 hasConceptScore W2164105087C77411442 @default.
• W2164105087 hasIssue "7" @default.

• next