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- W2164111229 abstract "Molecular defects in Factor VIII (FVIII), such as haemophilia A-related mutations or denaturative conformational changes, may affect the stability of FVIII as well as its interactions with physiological activators, von Willebrand Factor, phospholipid, or conformationally sensitive antibodies. We summarize the contemporary assays which allow identification of impaired functional interactions of FVIII that cause a reduction or loss of its cofactor activity and/or increased immunogenicity. These assays can potentially be used for detection of molecular defects in FVIII and elucidation of the function impaired by these defects." @default.
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- W2164111229 date "2002-08-01" @default.
- W2164111229 modified "2023-10-14" @default.
- W2164111229 title "Molecular defects in coagulation Factor VIII and their impact on Factor VIII function" @default.
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- W2164111229 doi "https://doi.org/10.1046/j.1423-0410.2002.00183.x" @default.
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