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- W2164112876 abstract "The study goal was to determine the half-life elimination of cocaine and benzoylecgonine (BZE) in the newborn. Three 0.3-mL blood samples were collected during the first day of life. Urine was collected once daily. Cocaine and BZE concentrations were determined by gas chromatography-mass spectrometry. An extraction method was developed for measuring low concentrations of cocaine and BZE in small (0.1 mL) blood samples. Cocaine had a half-life of 11.6 h in one subject. The half-life of BZE during the first day of life, based on blood data in 13 subjects, was 16 h (95% confidence interval [CI], 12.8 to 21.4 h). The half-life of BZE during the first week of life, based on urine data in 16 subjects, was 11.2 h (95% CI, 10.1 to 11.8 h). The novel extraction method for small blood sample volumes should be applicable to other basic drugs." @default.
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- W2164112876 date "1999-01-01" @default.
- W2164112876 modified "2023-09-23" @default.
- W2164112876 title "Cocaine Metabolite Kinetics in the Newborn*" @default.
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- W2164112876 doi "https://doi.org/10.1093/jat/23.1.24" @default.
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