FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164121910> ?p ?o ?g. }

• W2164121910 endingPage "66" @default.
• W2164121910 startingPage "55" @default.
• W2164121910 abstract "Background Between November, 2006, and May, 2008, a subacute neurological syndrome affected workers from two swine abattoirs in Minnesota and Indiana who had occupational exposure to aerosolised porcine brain. We aimed to describe the pathogenic and immunological characteristics of this illness. Methods All patients from two abattoirs who presented or were referred to the Mayo Clinic (Rochester, MN, USA) with neurological symptoms were included. We recorded details of exposure to aerosolised brain tissue and did comprehensive neurological, laboratory, neuroimaging, electrophysiological, pathological, and autoimmune serological assessments. Healthy controls were recruited from the community and from workers at the plant in Minnesota. Findings 24 patients were identified (21 from Minnesota, three from Indiana). The shortest duration from first exposure to symptom onset was 4 weeks. No infectious agent that could trigger disease was identified. All patients developed polyradiculoneuropathy, which was usually sensory predominant and painful. Two patients had initial CNS manifestations: transverse myelitis and meningoencephalitis. Nerve conduction studies localised abnormalities to the most proximal and distal nerve segments. Quantitative sensory and autonomic testing revealed involvement of large and small sensory fibres and sweat fibres. MRI showed prominent abnormalities of roots and ganglia. Nerve biopsies identified mild demyelination, axonal degeneration, and perivascular inflammation. Protein concentrations were high in the CSF of 18 (86%) of 21 patients. Sera from all patients and 29 (34%) of 85 unaffected workplace controls (but none of 178 community controls) had a distinctive neural-reactive IgG; 75% of patients' sera contained an IgG specific to myelin basic protein. Seropositivity correlated directly with exposure risk in patients and controls. 17 patients required immunomodulatory therapies, six improved spontaneously, and one was lost to follow-up after exposure stopped. Interpretation The neurological disorder described is autoimmune in origin and is related to occupational exposure to multiple aerosolised porcine brain tissue antigens. The pattern of nerve involvement suggests vulnerability of nerve roots and terminals where the blood–nerve barrier is most permeable. Funding Mayo Clinic Foundation; Minnesota Department of Health; Centers for Disease Control and Prevention." @default.
• W2164121910 created "2016-06-24" @default.
• W2164121910 creator A5005950462 @default.
• W2164121910 creator A5011018483 @default.
• W2164121910 creator A5013651117 @default.
• W2164121910 creator A5018483789 @default.
• W2164121910 creator A5049749614 @default.
• W2164121910 creator A5050683295 @default.
• W2164121910 creator A5055122406 @default.
• W2164121910 creator A5056256248 @default.
• W2164121910 creator A5057284626 @default.
• W2164121910 creator A5064400725 @default.
• W2164121910 creator A5067877202 @default.
• W2164121910 creator A5088136783 @default.
• W2164121910 creator A5089617870 @default.
• W2164121910 date "2010-01-01" @default.
• W2164121910 modified "2023-10-17" @default.
• W2164121910 title "An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive study" @default.
• W2164121910 cites W1922664700 @default.
• W2164121910 cites W1965126871 @default.
• W2164121910 cites W1966729617 @default.
• W2164121910 cites W1967414895 @default.
• W2164121910 cites W1974821266 @default.
• W2164121910 cites W1981329413 @default.
• W2164121910 cites W1985361393 @default.
• W2164121910 cites W1989988824 @default.
• W2164121910 cites W1998699294 @default.
• W2164121910 cites W2048931604 @default.
• W2164121910 cites W2057276736 @default.
• W2164121910 cites W2066874389 @default.
• W2164121910 cites W2076129653 @default.
• W2164121910 cites W2079641188 @default.
• W2164121910 cites W2086753880 @default.
• W2164121910 cites W2091287531 @default.
• W2164121910 cites W2093206847 @default.
• W2164121910 cites W2139235644 @default.
• W2164121910 cites W2160211535 @default.
• W2164121910 cites W2162179880 @default.
• W2164121910 cites W2338534098 @default.
• W2164121910 cites W2380488381 @default.
• W2164121910 doi "https://doi.org/10.1016/s1474-4422(09)70296-0" @default.
• W2164121910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19945916" @default.
• W2164121910 hasPublicationYear "2010" @default.
• W2164121910 type Work @default.
• W2164121910 sameAs 2164121910 @default.
• W2164121910 citedByCount "46" @default.
• W2164121910 countsByYear W21641219102012 @default.
• W2164121910 countsByYear W21641219102013 @default.
• W2164121910 countsByYear W21641219102014 @default.
• W2164121910 countsByYear W21641219102015 @default.
• W2164121910 countsByYear W21641219102016 @default.
• W2164121910 countsByYear W21641219102017 @default.
• W2164121910 countsByYear W21641219102018 @default.
• W2164121910 countsByYear W21641219102019 @default.
• W2164121910 countsByYear W21641219102020 @default.
• W2164121910 countsByYear W21641219102021 @default.
• W2164121910 countsByYear W21641219102022 @default.
• W2164121910 crossrefType "journal-article" @default.
• W2164121910 hasAuthorship W2164121910A5005950462 @default.
• W2164121910 hasAuthorship W2164121910A5011018483 @default.
• W2164121910 hasAuthorship W2164121910A5013651117 @default.
• W2164121910 hasAuthorship W2164121910A5018483789 @default.
• W2164121910 hasAuthorship W2164121910A5049749614 @default.
• W2164121910 hasAuthorship W2164121910A5050683295 @default.
• W2164121910 hasAuthorship W2164121910A5055122406 @default.
• W2164121910 hasAuthorship W2164121910A5056256248 @default.
• W2164121910 hasAuthorship W2164121910A5057284626 @default.
• W2164121910 hasAuthorship W2164121910A5064400725 @default.
• W2164121910 hasAuthorship W2164121910A5067877202 @default.
• W2164121910 hasAuthorship W2164121910A5088136783 @default.
• W2164121910 hasAuthorship W2164121910A5089617870 @default.
• W2164121910 hasConcept C126322002 @default.
• W2164121910 hasConcept C141071460 @default.
• W2164121910 hasConcept C142724271 @default.
• W2164121910 hasConcept C159654299 @default.
• W2164121910 hasConcept C203014093 @default.
• W2164121910 hasConcept C2777052087 @default.
• W2164121910 hasConcept C2777464067 @default.
• W2164121910 hasConcept C2778621254 @default.
• W2164121910 hasConcept C2778691916 @default.
• W2164121910 hasConcept C2780168130 @default.
• W2164121910 hasConcept C45189115 @default.
• W2164121910 hasConcept C71924100 @default.
• W2164121910 hasConceptScore W2164121910C126322002 @default.
• W2164121910 hasConceptScore W2164121910C141071460 @default.
• W2164121910 hasConceptScore W2164121910C142724271 @default.
• W2164121910 hasConceptScore W2164121910C159654299 @default.
• W2164121910 hasConceptScore W2164121910C203014093 @default.
• W2164121910 hasConceptScore W2164121910C2777052087 @default.
• W2164121910 hasConceptScore W2164121910C2777464067 @default.
• W2164121910 hasConceptScore W2164121910C2778621254 @default.
• W2164121910 hasConceptScore W2164121910C2778691916 @default.
• W2164121910 hasConceptScore W2164121910C2780168130 @default.
• W2164121910 hasConceptScore W2164121910C45189115 @default.
• W2164121910 hasConceptScore W2164121910C71924100 @default.
• W2164121910 hasIssue "1" @default.
• W2164121910 hasLocation W21641219101 @default.
• W2164121910 hasLocation W21641219102 @default.

• next