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• W2164137922 endingPage "1071" @default.
• W2164137922 startingPage "1058" @default.
• W2164137922 abstract "Disruption of fast axonal transport (FAT) and intracellular Ca 2+ dysregulation are early pathological events in Alzheimer's disease (AD). Amyloid-β oligomers (AβOs), a causative agent of AD, impair transport of BDNF independent of tau by nonexcitotoxic activation of calcineurin (CaN). Ca 2+ -dependent mechanisms that regulate the onset, severity, and spatiotemporal progression of BDNF transport defects from dendritic and axonal AβO binding sites are unknown. Here we show that BDNF transport defects in dendrites and axons are induced simultaneously but exhibit different rates of decline. The spatiotemporal progression of FAT impairment correlates with Ca 2+ elevation and CaN activation first in dendrites and subsequently in axons. Although many axonal pathologies have been described in AD, studies have primarily focused only on the dendritic effects of AβOs despite compelling reports of presynaptic AβOs in AD models and patients. Indeed, we observe that dendritic CaN activation converges on Ca 2+ influx through axonal voltage-gated Ca 2+ channels to impair FAT. Finally, FAT defects are prevented by dantrolene, a clinical compound that reduces Ca 2+ release from the ER. This work establishes a novel role for Ca 2+ dysregulation in BDNF transport disruption and tau-independent Aβ toxicity in early AD." @default.
• W2164137922 created "2016-06-24" @default.
• W2164137922 creator A5031571861 @default.
• W2164137922 creator A5067954882 @default.
• W2164137922 date "2015-03-15" @default.
• W2164137922 modified "2023-10-16" @default.
• W2164137922 title "Dendritic and axonal mechanisms of Ca²⁺ elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons" @default.
• W2164137922 cites W1413896671 @default.
• W2164137922 cites W1522472244 @default.
• W2164137922 cites W1577837690 @default.
• W2164137922 cites W1605000502 @default.
• W2164137922 cites W1869318026 @default.
• W2164137922 cites W1966516510 @default.
• W2164137922 cites W1967626349 @default.
• W2164137922 cites W1969971113 @default.
• W2164137922 cites W1970049338 @default.
• W2164137922 cites W1970291634 @default.
• W2164137922 cites W1974476511 @default.
• W2164137922 cites W1976602187 @default.
• W2164137922 cites W1978116973 @default.
• W2164137922 cites W1982810155 @default.
• W2164137922 cites W1985069323 @default.
• W2164137922 cites W1989133066 @default.
• W2164137922 cites W1990402345 @default.
• W2164137922 cites W1993208227 @default.
• W2164137922 cites W1993411778 @default.
• W2164137922 cites W1996764498 @default.
• W2164137922 cites W1997124058 @default.
• W2164137922 cites W2005128877 @default.
• W2164137922 cites W2006524711 @default.
• W2164137922 cites W2006788743 @default.
• W2164137922 cites W2006994573 @default.
• W2164137922 cites W2007273125 @default.
• W2164137922 cites W2009828191 @default.
• W2164137922 cites W2019620146 @default.
• W2164137922 cites W2020580902 @default.
• W2164137922 cites W2025306989 @default.
• W2164137922 cites W2025484210 @default.
• W2164137922 cites W2025722885 @default.
• W2164137922 cites W2030602441 @default.
• W2164137922 cites W2035460326 @default.
• W2164137922 cites W2035763500 @default.
• W2164137922 cites W2041956586 @default.
• W2164137922 cites W2044904524 @default.
• W2164137922 cites W2045233439 @default.
• W2164137922 cites W2045270516 @default.
• W2164137922 cites W2045314223 @default.
• W2164137922 cites W2046296412 @default.
• W2164137922 cites W2046672806 @default.
• W2164137922 cites W2046866871 @default.
• W2164137922 cites W2050660267 @default.
• W2164137922 cites W2051268743 @default.
• W2164137922 cites W2053665966 @default.
• W2164137922 cites W2059189380 @default.
• W2164137922 cites W2065023793 @default.
• W2164137922 cites W2065617338 @default.
• W2164137922 cites W2070546151 @default.
• W2164137922 cites W2078212921 @default.
• W2164137922 cites W2081076741 @default.
• W2164137922 cites W2082328452 @default.
• W2164137922 cites W2082429191 @default.
• W2164137922 cites W2100421543 @default.
• W2164137922 cites W2105981057 @default.
• W2164137922 cites W2107069710 @default.
• W2164137922 cites W2107975828 @default.
• W2164137922 cites W2108755352 @default.
• W2164137922 cites W2110949240 @default.
• W2164137922 cites W2116489922 @default.
• W2164137922 cites W2116847730 @default.
• W2164137922 cites W2118694086 @default.
• W2164137922 cites W2121415412 @default.
• W2164137922 cites W2124140905 @default.
• W2164137922 cites W2131737428 @default.
• W2164137922 cites W2133378263 @default.
• W2164137922 cites W2136322671 @default.
• W2164137922 cites W2140323904 @default.
• W2164137922 cites W2144987307 @default.
• W2164137922 cites W2149164514 @default.
• W2164137922 cites W2161819609 @default.
• W2164137922 cites W2165021720 @default.
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• W2164137922 doi "https://doi.org/10.1091/mbc.e14-12-1612" @default.
• W2164137922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4357506" @default.
• W2164137922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25609087" @default.
• W2164137922 hasPublicationYear "2015" @default.
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• W2164137922 hasAuthorship W2164137922A5031571861 @default.

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