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- W2164144387 abstract "G-quadruplexes are four-stranded nucleic acid structures whose biological functions remain poorly understood. In the yeast S. cerevisiae, we report that G-quadruplexes form and, if not properly processed, pose a specific challenge to replication. We show that the G-quadruplex-prone CEB1 tandem array is tolerated when inserted near ARS305 replication origin in wild-type cells but is very frequently destabilized upon treatment with the potent Phen-DC(3) G-quadruplex ligand, or in the absence of the G-quadruplex-unwinding Pif1 helicase, only when the G-rich strand is the template of leading-strand replication. The orientation-dependent instability is associated with the formation of Rad51-Rad52-dependent X-shaped intermediates during replication detected by two-dimensional (2D) gels, and relies on the presence of intact G-quadruplex motifs in CEB1 and on the activity of ARS305. The asymmetrical behaviour of G-quadruplex prone sequences during replication has implications for their evolutionary dynamics within genomes, including the maintenance of G-rich telomeres." @default.
- W2164144387 created "2016-06-24" @default.
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- W2164144387 date "2011-08-26" @default.
- W2164144387 modified "2023-10-18" @default.
- W2164144387 title "G-quadruplex-induced instability during leading-strand replication" @default.
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- W2164144387 doi "https://doi.org/10.1038/emboj.2011.316" @default.
- W2164144387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3209785" @default.
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