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- W2164144749 abstract "The emergence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, particularly Escherichia coli and Klebsiella pneumoniae, presents significant diagnostic and therapeutic challenges to the management of infections due to these organisms. Detection of resistant isolates is difficult based on routine susceptibility testing performed by a clinical microbiology laboratory. In addition, the utility of penicillins, cephalosporins, and aztreonam in treating serious infections due to these organisms is uncertain due to reports of treatment failure despite apparent in vitro susceptibility. A critical evaluation of the English literature was performed on treatment outcomes associated with ESBL-producing Enterobacteriaceae. Imipenem and extended-spectrum cephalosporins were commonly administered. Discordant outcomes in relation to in vitro susceptibility of the agent did not occur exclusively with cephalosporins but with all drugs including imipenem. Until more outcome data are available, drug selection must take into consideration whether or not an outbreak is occurring and whether therapy is empirical or definitive." @default.
- W2164144749 created "2016-06-24" @default.
- W2164144749 creator A5013513119 @default.
- W2164144749 date "2001-05-01" @default.
- W2164144749 modified "2023-09-24" @default.
- W2164144749 title "Therapeutic Challenges Associated with Extended-Spectrum, β-Lactamase-Producing<i>Escherichia coli</i>and<i>Klebsiella pneumoniae</i>" @default.
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- W2164144749 doi "https://doi.org/10.1592/phco.21.6.583.34537" @default.
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