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- W2164159855 abstract "Within the past decade, remarkable similarities between the molecular organization of animal and plant systems for non-self discrimination were revealed. Obvious parallels exist between the molecular structures of the receptors mediating the recognition of pathogen- or microbe-associated molecular patterns (PAMPs/MAMPs) with plant pattern recognition receptors (PRRs) strikingly resembling mammalian Toll-like receptors. Mitogen-activated protein (MAP) kinase cascades, leading to the transcriptional activation of immunity-associated genes, illustrate the conservation of whole molecular building blocks of PAMP/MAMP-induced signaling. Enteropathogenic Salmonella and Escherichia coli use a type three secretion system (T3SS) to inject effector proteins into the mammalian host cell to subvert defense mechanisms and promote gut infection. Lately, disease occurrence was increasingly associated with bacteria-contaminated fruits and vegetables and common themes have emerged with regard to whether and how effectors target innate immune responses in a trans-kingdom manner. We propose that numerous Salmonella or E. coli effectors may be active in planta and tend to target central components (hubs) of immune signaling pathways." @default.
- W2164159855 created "2016-06-24" @default.
- W2164159855 creator A5069526346 @default.
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- W2164159855 date "2014-07-22" @default.
- W2164159855 modified "2023-09-26" @default.
- W2164159855 title "Killing two birds with one stone: trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteria" @default.
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- W2164159855 doi "https://doi.org/10.3389/fmicb.2014.00320" @default.
- W2164159855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4105635" @default.
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